Molecules, Год журнала: 2024, Номер 29(15), С. 3482 - 3482
Опубликована: Июль 25, 2024
Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,
Язык: Английский
Процитировано
24Nanotechnology-based non-invasive strategies in ocular therapeutics: Approaches, limitations to clinical translation, and safety concerns
Contact Lens and Anterior Eye, Год журнала: 2025, Номер unknown, С. 102367 - 102367
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments
Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 125 - 125
Опубликована: Янв. 18, 2024
Recent studies have demonstrated that Sirtuin-1 (SIRT-1)-activating molecules exert a protective role in degenerative ocular diseases. However, these hardly reach the back of eye due to poor solubility aqueous environments and low bioavailability after topical application on eye’s surface. Such hindrances, combined with stability issues, call for need innovative delivery strategies. Within this context, development self-nanoemulsifying drug systems (SNEDDS) SIRT-1 can represent promising approach. The aim work was design optimize SNEDDS two natural agonists, resveratrol (RSV) melatonin (MEL), potential implications treating diabetic retinopathy. Pre-formulation were performed by Design Experiment (DoE) approach construct ternary phase diagram. optimization carried out using Response Surface Methodology (RSM). Four types consisting different surfactants (Tween® 80, Tween® 20, Solutol® HS15, Cremophor® EL) optimized achieve best physico-chemical parameters application. Stability tests indicated produced 80 formulation preserved molecules, so it was, therefore, selected further technological studies. prepared Capryol® PGMC, Transcutol® P loaded RSV or MEL. evaluated other parameters, such as mean size (found be ˂50 nm), homogeneity (PDI < 0.2), emulsion time (around 40 s), transparency, content (>90%), mucoadhesion strength, vitro release, pH osmolarity, dilution, cloud point. Finally, an evaluation rabbit corneal epithelial cell line (SIRC) assess their cytocompatibility. overall results suggest used nanocarriers
Язык: Английский
Процитировано
14Recent advances in encapsulation of resveratrol for enhanced delivery
Food Chemistry, Год журнала: 2024, Номер 460, С. 140475 - 140475
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
10Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery
Pharmaceuticals, Год журнала: 2024, Номер 17(4), С. 511 - 511
Опубликована: Апрель 16, 2024
Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of eye. Conventional dosage forms often fail achieve optimal therapeutic outcomes poor bioavailability, short retention time, off-target effects. In recent years, vesicular systems have emerged as promising solutions address these challenges. Vesicular systems, such liposome, niosome, ethosome, transfersome, others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, spanlastics), offer several advantages for ocular delivery. These include improved prolonged time on surface, reduced systemic side effects, protection drugs from enzymatic degradation dilution by tears. Moreover, formulations can be engineered targeted specific tissues or cells, enhancing efficacy while minimizing They also enable encapsulation a wide range molecules, including hydrophilic, hydrophobic, macromolecular drugs, possibility combination therapy facilitating co-delivery multiple drugs. This review examines their over conventional production techniques, applications in management diseases.
Язык: Английский
Процитировано
9The Application of Glycosylated Liposomes in Targeted Drug Delivery
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106638 - 106638
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Preparation and Antioxidant Activity of New Carboxymethyl Chitosan Derivatives Bearing Quinoline Groups
Marine Drugs, Год журнала: 2023, Номер 21(12), С. 606 - 606
Опубликована: Ноя. 24, 2023
A total of 16 novel carboxymethyl chitosan derivatives bearing quinoline groups in four classes were prepared by different synthetic methods. Their chemical structures confirmed Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and elemental analysis. The antioxidant experiment results vitro (including DPPH radical scavenging ability, superoxide anion hydroxyl ferric reducing power) demonstrated that adding to (CS) (CMCS) enhanced the ability CS CMCS. Among them, both N, O-CMCS N-TM-O-CMCS showed over 70%. In addition, their radicals reached more than 90% at maximum tested concentration 1.6 mg/mL. Moreover, cytotoxicity assay was carried out on L929 cells MTT method, indicated all no (cell viability > 75%) except derivative 1a, which low 1000 μg/mL 50.77 ± 4.67%). conclusion, remarkable weak cytotoxicity, highlighting potential use food medical applications.
Язык: Английский
Процитировано
18Strategies for the Preparation of Chitosan Derivatives for Antimicrobial, Drug Delivery, and Agricultural Applications: A Review
Molecules, Год журнала: 2023, Номер 28(22), С. 7659 - 7659
Опубликована: Ноя. 18, 2023
Chitosan has received much attention for its role in designing and developing novel derivatives as well applications across a broad spectrum of biological physiological activities, owing to desirable characteristics such being biodegradable, biopolymer, overall eco-friendliness. The main objective this review is explore the recent chemical modifications chitosan that have been achieved through various synthetic methods. These are categorized based on their pathways or presence common functional groups, which include alkylated, acylated, Schiff base, quaternary ammonia, guanidine, heterocyclic rings. We also described derivatives, along with nanomaterials, mechanisms, prospective challenges, especially areas antimicrobial targeted drug delivery diseases, plant agricultural domains. accumulation these findings potential offer insight not only into innovative approaches preparation but diverse applications. insights may spark ideas development carriers, particularly antimicrobial, medicinal, fields.
Язык: Английский
Процитировано
17Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems
Nutrients, Год журнала: 2024, Номер 16(11), С. 1715 - 1715
Опубликована: Май 30, 2024
Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there need for early effective management in patients with stage DR before its progression into more severe sight-threatening stage. Nutraceuticals, natural functional foods few side effects, have been proposed to be beneficial Over decades, many studies, either vitro or vivo, demonstrated advantages number nutraceuticals their antioxidative, anti-inflammatory, neuroprotective, vasoprotective effects. only clinical trials conducted, outcomes varied. The low bioavailability instability indeed hindered utilization use. In this context, nanoparticle carriers developed deliver improve bioavailability. Despite preclinical nature, research interventive may yield promising information applications.
Язык: Английский
Процитировано
5Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138772 - 138772
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
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