Hepatocellular
carcinoma
(HCC)
is
one
serious
cause
cancer-associated
deaths
worldwide.
Poor
bioavailability
and
non-specific
targeting
of
drugs
a
challenge.
In
this
study,
attempt
to
increase
targetability
hydrophilic
was
made
using
nanoparticles.
Study
reports
synthesis
formulation
galactosylated
albumin-based
nanoparticles
(GEM-LA-BSA
NPs)
further
optimized
by
central
composite
design.
Gemcitabine
(GEM)
broad-spectrum
anticancer
drug
for
liver
other
cancers.
LA-BSA
conjugate
synthesized
characterized
1H-NMR,
FT-IR
SDS-PAGE.
Conjugates
were
used
fabrication
nanoparticulate
formulations.
A
comparative
analysis
performed
between
BSA
NPs,
GEM-BSA
GEM-LA-BSA
NPs
estimate
the
efficacy
formulations
against
HepG2
cells.
Size
optimal
71.52
±
4.05
nm
with
reduced
release
(57.78
4.10%)
in
48
h.
Morphology
like
aggregates
HR-TEM.
In-vitro
studies
cells
indicated
better
cytotoxicity
than
GEM
(IC50
values
226.42
11.32
366.03
11.93
μg/mL,
respectively).
In-vivo
SD
rats
showed
almost
two
folds
half-life.
Better
pharmacokinetics
IC50
established
promising
outcome.
Hence,
portrayed
immense
potential
as
an
effective
delivery
system
drugs.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
7, С. 100238 - 100238
Опубликована: Март 11, 2024
The
clinical
advancement
of
protein-based
nanomedicine
has
revolutionized
medical
professionals'
perspectives
on
cancer
therapy.
Protein-based
nanoparticles
have
been
exploited
as
attractive
vehicles
for
due
to
their
unique
properties
derived
from
naturally
biomacromolecules
with
superior
biocompatibility
and
pharmaceutical
features.
Furthermore,
the
successful
translation
Abraxane™
(paclitaxel-based
albumin
nanoparticles)
into
application
opened
a
new
avenue
nanomedicine.
In
this
mini-review
article,
we
demonstrate
rational
design
recent
progress
along
applications
in
diagnosis
therapy
literature.
current
challenges
hurdles
that
hinder
are
highlighted.
Finally,
future
translating
clinic
identified.
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 696 - 696
Опубликована: Июнь 6, 2024
The
transcription
factor
nuclear
erythroid
2-related
2
(Nrf2)
represents
the
master
regulator
of
cellular
antioxidant
response
and
plays
a
critical
role
in
tumorigenesis.
This
includes
preventive
effect
Nrf2
on
cell
death
through
ferroptosis,
which
an
essential
mechanism
therapy
resistance
malignant
tumors,
such
as
pancreatic
ductal
adenocarcinoma
(PDAC)
one
most
aggressive
still
incurable
tumors.
Addressing
this
issue,
we
provide
overview
mediated
with
particular
emphasis
its
mitochondria
organelle
responsible
for
execution
ferroptosis.
We
further
outline
how
deregulated
adds
to
progression
PDAC,
especially
respect
ferroptosis
anti-cancer
drug
killing
is
impaired
by
resistance.
Our
review
discusses
recent
approaches
inhibition
natural
synthetic
compounds
overcome
based
enhanced
Finally,
outlook
therapeutic
strategies
combined
inducing
drugs.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Colorectal
cancer
is
a
lethal
malignancy
that
begins
from
acquired/inherent
premalignant
lesions.
Thus,
targeting
these
lesions
at
an
early
stage
of
the
disease
could
impede
oncogenesis
and
maximize
efficacy.
The
present
work
underscores
combinatorial
therapy
paclitaxel
(PTX)
glycyrrhizin
(GL)
delivered
via
gelatin-derived
core-shell
nanoparticles
[AC-PCL(GL
+
PTX)-GNPs]
for
effective
management
precancerous
desolvation
method
was
adopted
to
prepare
GL-loaded
gelatin
(GL-GNPs),
which
were
coated
with
PTX
AC-PCL.
prepared
NPs
exhibited
optimal
physical
attributes
had
spherical
morphology,
as
analyzed
by
transmission
electron
microscopy
field-emission
scanning
microscopy.
In
vitro
release
studies
revealed
sustained
∼96
h.
Cell
culture
in
HTC
116,
HT-29
cells
showed
synergistic
action
CI
<
0.9
DRI
>
1.
Moreover,
AC-PCL(GL
PTX)-GNPs
amplified
intracellular
uptake
thus
significantly
reduced
IC50.
Pharmacokinetic
substantiated
pharmacokinetic
parameters
(AUC0-∞,
Cmax,
etc.).
vivo
1,2-dimethyl
hydrazine-induced
model
decrease
number
lesions,
mucin
depletion,
subside
infiltrations.
An
immunohistochemical
study
elevated
expression
caspase-9
suppressed
VEGF
Ki-67.
Toxicity
insignificant
changes
systemic
biomarkers
along
no
alterations
organ
morphology
hemocompatibility.
essence,
render
competent
safer
tactic
regulate
early-stage
