International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135515 - 135515
Опубликована: Сен. 1, 2024
Язык: Английский
Molecules, Год журнала: 2025, Номер 30(2), С. 207 - 207
Опубликована: Янв. 7, 2025
The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.
Язык: Английский
Процитировано
2
BMEMat, Год журнала: 2024, Номер 2(2)
Опубликована: Март 1, 2024
Abstract Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis develop treatments against OA. Hydrogels, designed striking resemblance the extracellular matrix, offer biomimetic interaction biological tissues, presenting promising avenue OA amelioration. As result, biocompatible hydrogels erected incorporating on‐demand bioactivities optimize intra‐articular microenvironment, thereby alleviating symptoms fostering eventual regeneration of articular joints. This review highlights collaborative objectives underlying establishment this tissue encompassing mechanical modulation, anti‐inflammation, regeneration. Specifically, we consolidate recent advances in hydrogel‐based biomaterials, serving as engineering scaffolds replicate lubrication properties natural joints or bioactive agent‐loaded vehicles combat localized inflammation. Additionally, function cell facilitate maintenance cellular homeostasis contribute advancement cartilage Finally, outlines prospective directions hydrogel‐mediated therapies.
Язык: Английский
Процитировано
15
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105990 - 105990
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
11
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Although 3D printing is becoming a dominant technique for scaffold preparation in bone tissue engineering (TE), developing hydrogel-based ink compositions with bioactive and self-healing properties remains challenge. This research focuses on based composite hydrogel, which maintains its after incorporating glass 3D-printable. The plain hydrogel was synthesized using natural polymers of 1 wt % N-carboxyethyl chitosan, 2 hyaluronic acid aldehyde, 0.3 adipic hydrazide, alginate (ALG) (2, 5, 10 %). Bioactive (BG) (0 5 w/v %) particles were incorporated into the matrix to obtain an osteogenic hydrogel. material characterized via rheology, field emission scanning electron microscopy/energy-dispersive X-ray spectroscopy (FESEM/EDS), Fourier transform infrared (FTIR) spectroscopy, diffraction (XRD), swelling, degradation, bioactivity, vitro cellular assessments. Rheological evaluations confirmed that specimen 0 BG ALG exhibited highest G', G″, viscosity values. All specimens self-healing, provided by two reversible dynamic bonds, namely, imine acylhydrazone. Bioactivity evaluation SBF immersion revealed formation HA hydrogels. MTT cytotoxicity assay MG63 indicated sample containing had cell viability (95 ± 1.02%) culture day 3. developed approach presents promising formulation high potential extrusion-based TE constructs.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140431 - 140431
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
7
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(6), С. 3612 - 3630
Опубликована: Май 30, 2024
Hydrophilic and biocompatible hydrogels are widely applied as ideal scaffolds in tissue engineering. The "smart" gelation material can alter its structural, physiochemical, functional features answer to various endo/exogenous stimuli better biomimic the endogenous extracellular matrix for engineering of cells tissues. Light irradiation owns a high spatial-temporal resolution, complete biorthogonal reactivity, fine-tunability thus induce physiochemical reactions within photoresponsive with good precision, efficiency, safety. Both gel structure (e.g., geometry, porosity, dimension) performance (like conductivity thermogenic or mechanical properties) hence be programmed on-demand yield biochemical biophysical signals regulating morphology, growth, motility, phenotype engineered Here we summarize strategies mechanisms encoding light-reactivity into hydrogel demonstrate how fantastically such responsive gels change their properties light desired improve applications including cargo delivery, dynamic three-dimensional cell culture, repair regeneration, aiming provide basis more translation clinic.
Язык: Английский
Процитировано
5
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 17, 2024
As the misuse of antibiotics increases bacterial resistance, treatment infected wounds caused by bacteria encounters significant challenges. Conventional antimicrobial dressings often fall short in their ability to inhibit infections while simultaneously promoting wound healing. To address this issue, a polysaccharide self-healing hydrogel (CPP@PDA/Que3) dressing is successfully developed incorporating quercetin and polydopamine nanoparticles into carboxymethyl chitosan matrix. The can be easily injected locally create protective barrier over wound, effectively stopping bleeding rapidly inhibiting inflammation. Furthermore, CPP@PDA/Que3 exhibits remarkable antioxidant antibacterial properties, stemming from combination near-infrared (NIR) photothermal therapy. It demonstrates eliminate 99.52% Staphylococcus aureus 99.39% Escherichia coli vitro experiments. Additionally, vivo healing experiment shows rate ≈97%. experimental results indicate that under NIR laser (808 nm) irradiation, polysaccharide-based significantly inhibits growth, reduces oxidative stress, expedites angiogenesis, thereby accelerates transition inflammation In summary, potential as dressing, providing novel approach for clinically advancing wounds.
Язык: Английский
Процитировано
5
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(4), С. 112 - 112
Опубликована: Апрель 22, 2024
Angiogenesis is vital for bone fracture healing and plays a significant role in the fate of orthopedic implants. The growth maintenance new blood vessels at site patients essential, which promotes clinical outcome plasma sprayed Ti (PST) coated In order to endow PST coating with pro-angiogenic effects, deferoxamine-loaded chitosan-based hydrogel was fabricated on surface. Polydopamine-modified chitosan (CS/PDA) exhibited enhanced bonding strength coatings as evidenced by scratch test. CS/PDA (CS/PDA-DFO) sustained drug-release property, cumulative concentration released DFO reached 20.21 μg/mL day 7. PST-CS/PDA higher wettability active group quantity viability adhesion characteristics human umbilical vein endothelial cells (HUVECs) upregulated secretion level nitric oxide vascular factor. Moreover, introduction further effects. Above all, this study offers novel approach developing implants showing
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134984 - 134984
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
4