Food Science & Nutrition,
Год журнала:
2024,
Номер
12(10), С. 7004 - 7016
Опубликована: Авг. 7, 2024
Abstract
Synthetic
food
antioxidants
such
as
tert‐butylhydroquinone
(TBHQ),
butylated
hydroxyanisole
(BHA),
and
propyl
gallate
(PG)
have
been
extensively
utilized
in
different
industries
because
of
their
high
protectant
activities
to
stop
spoilage
remove
foodborne
diseases
humans
animals.
It
would
be
emphasized
that
increasing
the
intake
through
intracellular
may
lead
cyto/genotoxicity,
complex
formation
with
biological
molecules
eventually
accelerate
progress
various
like
multiple
sclerosis,
diabetes,
neurological
disorders,
cardiac
vascular
disease,
cancer,
etc.
Therefore,
toxicity
is
one
challenging
subjects
due
extensive
use
food‐related
industries.
TBHQ,
BHA,
PG
cytotoxic,
genotoxic,
carcinogenic
effects
if
absorbed
doses
gastrointestinal
tract.
Thermodynamic
parameters
presented
hydrophobic
bind
plays
a
key
role
complexation
albumin.
The
molecular
modeling
results
showed
subdomain
IIA
vital
interaction
TBHQ
BHA
To
comprehend
mechanisms
cyto/genotoxicity
these
conformational
alterations
albumin
macromolecule,
we
aim
overview
numerous
types
research
evaluated
using
several
procedures.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Nanophytosomes
(NP
S
)
loaded
with
whole
pomegranate
fruit
extract
peel
and
arils
(PFE)
at
different
levels
of
phosphatidylcholine
(PC)
were
produced
using
a
thin‐film
hydration
method
reinforced
calcium
ions.
PFE
was
obtained
by
pressing
pomegranates,
followed
mixing
PC
ratios
1:1,
1:2,
1:3,
which
then
strengthens
the
phytosome
wall
CaCl
2
solutions
(1.35
2.70
mM)
lyophilized
to
create
stable
powder
form.
The
characteristics
NP
powders,
including
encapsulation
efficiency
(EE),
particle
size,
ζ‐potential,
polydispersity
index
(PDI),
structure,
microstructure,
thermal
properties,
evaluated.
Additionally,
storage
stability
phenolic
compounds
over
two
months
investigated.
demonstrated
appropriate
for
incorporation
into
system,
total
phenol
content
371.19
mg
GAE/g
dry
weight,
anthocyanins
300.68
mg/g,
flavonoids
194
mg/100
g,
an
antioxidant
activity
90.98%.
highest
EE
determined
be
98.53%,
indicating
its
unique
ability
as
nano‐carrier.
PFE‐loaded
NPs
showed
favorable
characteristics,
such
low
PDI
values
(<
0.5),
smaller
size
(170
nm),
spherical
morphology.
PFE‐NP
had
128.6
nm,
zeta
potential
−40.15
mV,
mobility
−3.15
μm
cm/Vs,
0.168,
98.53%.
optimized
nanoparticles
remained
4°C,
negligible
changes
in
(~10
(TPC),
PFE‐Nanophytosomes.
All
samples
better
temperatures
60
days.
PEF‐NPs
improved
while
improving
solubility,
masking
taste,
delivery
target
tissues,
can
considered
future
applications.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 464 - 464
Опубликована: Апрель 2, 2025
Natural
substances,
especially
those
derived
from
plants,
exhibit
a
diverse
range
of
therapeutic
benefits,
such
as
antioxidant,
anti-inflammatory,
anticancer,
and
antimicrobial
effects.
Nevertheless,
their
use
in
clinical
settings
is
frequently
impeded
by
inadequate
solubility,
limited
bioavailability,
instability.
Nanovesicular
carriers,
liposomes,
niosomes,
ethosomes,
transferosomes,
transethosomes,
cubosomes,
have
emerged
innovative
phytochemical
delivery
systems
to
address
these
limitations.
This
review
highlights
recent
developments
vesicular
nanocarriers
for
delivery,
emphasizing
preparation
techniques,
composition,
applications,
the
future
potential
systems.
Phytosomes,
along
with
key
advantages
various
are
extensively
described.
Various
vitro
vivo
characterization
techniques
utilized
evaluating
nanovesicular
carriers
summarized.
Completed
trials
patents
granted
nanovesicles
encapsulating
phytochemicals
designed
systemic
tabulated.
Phytochemical
via
faces
challenges
low
stability,
active
loading,
scalability
issues,
high
production
costs.
Additionally,
immune
clearance
regulatory
hurdles
hinder
application,
requiring
improved
carrier
design
formulation
techniques.
