The Journal of Physical Chemistry C,
Год журнала:
2024,
Номер
128(50), С. 21531 - 21538
Опубликована: Дек. 10, 2024
Chitosan
is
a
nontoxic
biopolymer
with
many
potential
biomedical
and
material
applications
due
to
its
biodegradability,
biocompatibility,
antimicrobial
properties.
Here,
fully
atomistic
molecular
dynamics
simulations
enhanced
sampling
methods
have
been
used
study
the
adsorption
mechanism
of
chitosan
oligomers
on
silica
surface
from
an
aqueous
solution.
The
free
energy
was
calculated
be
0.6
kcal
mol–1
per
monomer
in
0.15
mol
L–1
solution,
which
comparable
kBT
at
room
temperature.
loading
capacity
found
0.094
mg
m–2,
it
dominated
by
charge
compensation.
Furthermore,
hydrogen
bonding
between
analyzed.
nitrogen
hydroxyl
group
oxygen
atoms
were
main
contributors
silica.
These
findings
guide
experimental
design
chitosan-coated
nanoparticles
for
such
as
drug
delivery
or
additives
food
packaging.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 207 - 207
Опубликована: Янв. 7, 2025
The
scientific
interest
in
the
chemical
modification
of
chitosan
to
increase
its
solubility
and
application
has
led
conjugation
with
Schiff
bases,
which
are
interesting
scaffolds
endowed
diverse
biological
properties.
resultant
chitosan-based
bases
(CSBs)
widely
studied
literature
due
myriad
activities
exerted,
both
catalytic
biological,
including
anticancer,
anti-inflammatory,
antioxidant,
especially
antimicrobial
ones.
Antimicrobial
resistance
(AMR)
is
one
major
public
health
challenges
twenty-first
century
because
it
represents
a
threat
prevention
treatment
growing
number
bacterial,
parasitic,
viral,
fungal
infections
that
no
longer
treatable
available
drugs.
Thus,
this
review,
we
present
brief
outline
CSBs
as
well
their
complexes
metals,
particular
focus
on
recent
regarding
effect
these
captivating
derivatives.
Journal of drug targeting,
Год журнала:
2024,
Номер
32(6), С. 655 - 671
Опубликована: Апрель 23, 2024
Oral
route
of
drug
administration
is
typically
the
initial
option
for
because
it
both
practical
and
affordable.
However,
major
drawback
this
includes
release
at
a
specified
place
thus
reduces
bioavailability.
This
could
be
overcome
by
utilising
gastroretentive
delivery
system
(GRRDS).
Prolonged
stomach
retention
improves
bioavailability
increases
solubility
medicines
that
are
unable
to
dissolve
in
high
pH
environments.
Many
recent
advancements
floating,
bio
adhesive,
magnetic,
expandable,
raft
forming
ion
exchange
systems
have
been
made
had
led
towards
advanced
form
delivery.
From
past
few
years,
floating
has
most
commonly
utilised
delayed
manner.
Various
polymers
manufacturing
these
systems,
including
alginates,
chitosan,
pectin,
carrageenan's,
xanthan
gum,
hydroxypropyl
cellulose,
carbomer,
polyethylene
oxide
sodium
carboxy
methyl
cellulose.
Chitosan,
pectin
gum
found
used
inclusion
complex
study
aimed
define
various
types
as
well
also
highlights
advances
future
perspectives
system.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10377 - 10377
Опубликована: Сен. 26, 2024
Polymers
of
natural
origin,
such
as
representatives
various
polysaccharides
(e.g.,
cellulose,
dextran,
hyaluronic
acid,
gellan
gum,
etc.),
and
their
derivatives,
have
a
long
tradition
in
biomedical
applications.
Among
them,
the
use
chitosan
safe,
biocompatible,
environmentally
friendly
heteropolysaccharide
has
been
particularly
intensively
researched
over
last
two
decades.
The
potential
using
for
medical
purposes
is
reflected
its
unique
cationic
nature,
viscosity-increasing
gel-forming
ability,
non-toxicity
living
cells,
antimicrobial
activity,
mucoadhesiveness,
biodegradability,
well
possibility
chemical
modification.
intuitive
clay
minerals
treatment
superficial
wounds
known
traditional
medicine
thousands
years.
To
improve
efficacy
overcome
ubiquitous
bacterial
resistance,
beneficial
properties
utilized
preparation
chitosan–clay
mineral
bionanocomposites.
focus
this
review
on
composites
containing
with
montmorillonite
halloysite
minerals.
This
highlights
antibacterial
bionanocomposites
drug
delivery
topical
skin
infections
wound
healing.
Finally,
an
overview
preparation,
characterization,
possible
future
perspectives
related
to
these
advancing
applications
presented.
