Polysaccharide-based drug delivery targeted approach for colon cancer treatment: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139177 - 139177

Опубликована: Янв. 1, 2025

Язык: Английский

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Biomolecule-based engineered nanoparticles for Cancer Theranostics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489

Опубликована: Фев. 3, 2025

Язык: Английский

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Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117118 - 117118

Опубликована: Июль 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Язык: Английский

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Recent advances of intelligent polymer gels as active carriers for medical imaging-guided cancer therapy: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140451 - 140451

Опубликована: Янв. 1, 2025

Язык: Английский

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Stabilization of chitosan-based nanomedicines in cancer therapy: a review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143016 - 143016

Опубликована: Апрель 1, 2025

Язык: Английский

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Oligonucleotide based nanogels for cancer therapeutics

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131401 - 131401

Опубликована: Апрель 4, 2024

Язык: Английский

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Advancing Eco-friendly Biomedicine: Sustainable Nanocomposites as Platforms for Genetic Vaccines

Опубликована: Янв. 1, 2025

Язык: Английский

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Mechanical and biological properties of 3D printed bone tissue engineering scaffolds

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 4, 2025

Bone defects have historically represented a significant challenge in clinical practice, with traditional surgical intervention remaining the gold standard for their management. However, due to problem of origin autologous and allogeneic bone complex diverse defects, methods sometimes cannot meet treatment needs expectations patients. The development tissue engineering 3D printing technology provides new ideas defect repair. Ideal bioscaffold materials must good mechanical properties, biocompatibility, osteoinduction conduction capabilities. Additionally, factors such as degradation rate, appropriate porosity sustained antibacterial effect be taken into account. combination synthetic composite biomaterial scaffolds has become well-established approach offering innovative solutions combined application seed cells, signalling biological is also beneficial improve therapeutic defects. This article will therefore examine some most commonly used technologies prevalent suitable printing. An analysis conducted on properties these elucidate respective advantages limitations.

Язык: Английский

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Advanced ultrasounds-assisted natural deep eutectic solvents green strategy for the sustainable extraction of biocompatible nano-hydroxyapatite from fish scales

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127515 - 127515

Опубликована: Апрель 1, 2025

Язык: Английский

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PEGylated SOCS3 Mimetics Encapsulated into PLGA-NPs as Selective Inhibitors of JAK/STAT Pathway in TNBC Cells

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 7237 - 7251

Опубликована: Июль 1, 2024

Introduction: SOCS3 (suppressor of cytokine signaling 3) protein is a crucial regulator cytokine-induced inflammation, and its administration has been shown to have therapeutic effects. Recently, we designed chimeric proteomimetic SOCS3, mimicking the interfacing regions ternary complex composed JAK2 (Janus kinase 2) gp130 (glycoprotein 130) proteins. The derived peptide, KIRCONG chim, demonstrated limited mimetic function owing poor water solubility. Methods: We report investigations concerning PEGylated variant mimetic, named bearing PEG (Polyethylene glycol) moiety as linker noncontiguous regions. Its ability bind catalytic domain was evaluated through MST (MicroScale Thermophoresis), well stability in biological serum assays. structural features cyclic compounds were investigated by CD (circular dichroism), nuclear magnetic resonance (NMR), molecular dynamic (MD) studies. To evaluate cellular effects, employed PLGA-nanoparticle delivery system after characterization using DLS SEM techniques. Results: chim PEG-revealed selective penetration into triple-negative breast cancer (TNBC) MDA-MB-231 cells with respect human epithelial cell line (MCF10A), acting potent inhibitor STAT3 phosphorylation. Discussion: Overall, data indicated that miniaturization promising approach for aberrant dysregulation JAK/STAT during progression. Keywords: protein, pathway, peptides, nanoparticles

Язык: Английский

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