Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation DOI
Sankha Bhattacharya, Shashikant B. Bagade, Preeti C. Sangave

и другие.

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Язык: Английский

Advanced Applications of DNA Hydrogels in Fluorescence Sensing DOI

Zixiao Ma,

Sheng Tang, Wei Shen

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 180, С. 117907 - 117907

Опубликована: Авг. 13, 2024

Язык: Английский

Процитировано

3
Intelligent responsive nanogels: New Horizons in cancer therapy DOI
Mazlina Musa, Xinxin Sun, Jianbin Shi

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050

Опубликована: Дек. 5, 2024

Язык: Английский

Процитировано

3
Construction of biomimetic camouflaged neutrophil membrane nanoparticles for precise delivery and augmented glioma cancer treatment DOI

Yongyan Bi,

Peiyu Qian,

Zuopeng Su

и другие.

Process Biochemistry, Год журнала: 2024, Номер 145, С. 229 - 242

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

2
Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation DOI
Sankha Bhattacharya, Shashikant B. Bagade, Preeti C. Sangave

и другие.

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Язык: Английский

Процитировано

1