Exosomal non-coding RNAs in the regulation of bone metabolism homeostasis: molecular mechanism and therapeutic potential
Heliyon,
Год журнала:
2025,
Номер
11(2), С. e41632 - e41632
Опубликована: Янв. 1, 2025
Bone
metabolism
is
a
dynamic
balance
between
bone
formation
and
absorption
regulated
by
osteoblasts/osteoclasts.
metabolic
disorders
can
lead
to
disease.
Osteoporosis
(OP),
osteoarthritis
(OA)
femoral
head
necrosis
(ONFH)
are
common
diseases.
At
present,
the
treatment
of
disease
still
mainly
relieve
pain
improve
joint
function.
However,
surgical
does
not
apply
vast
majority
high-risk
groups,
including
postmenopausal
women,
patients
with
diabetes,
cirrhosis,
etc.
Exosomes
(Exos)
nanoscale
membrane
vesicles
that
released
almost
all
cells.
Exos
rich
in
variety
bioactive
substances,
such
as
non-coding
RNAs,
nucleic
acids,
proteins
lipids.
In
view
structure
Exos,
it
protect
biologically
active
molecules
be
smoothly
delivered
target
cells
involved
regulation
cell
this
review,
we
focus
on
mechanism
function
homeostasis
mediated
exosomal
ncRNAs
(Exos-ncRNAs),
macrophage
polarization,
autophagy,
angiogenesis,
signal
transduction
competing
endogenous
RNA
(ceRNA).
We
summarized
therapeutic
strategies
potential
drugs
Exos-ncRNAs
Moreover,
discussed
shortcomings
research
directions
carrier
deliver
play
role.
Язык: Английский
MicroRNA expression profiles in sinonasal biopsies to support diagnosis of granulomatosis with polyangiitis
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 14, 2025
Objectives
To
identify
aberrantly
expressed
microRNAs
(miRNAs)
in
sinonasal
tissue
biopsies
of
patients
with
granulomatosis
polyangiitis
(GPA),
associate
their
expression
profiles
to
histopathology,
and
assess
differential
between
subgroups
clinically
proven
GPA
patients,
healthy
controls
exhibiting
inflammation
other
etiology.
Methods
We
included
formalin-fixed,
paraffin-embedded
biopsy
samples
mucosa
from
37
GPA,
15
etiology
14
control
normal
histology.
Of
the
20
had
characteristic
GPA-related
histological
features,
while
17
displayed
non-specific
histopathology
biopsy.
Assessment
parameters
was
performed
using
histopathological
techniques,
analysis
miRNA
miRCURY
LNA
miRNome
Human
PCR
Panels
quantitative
real-time
PCR.
Results
determined
306
miRNAs
samples,
which
different
extent
dysregulation
individual
patient
groups.
Based
on
potential
discriminate
controls,
non-GPA
subgroups,
11
further
assessed,
miR-1-3p/-21-3p/-93-5p/-155-5p/-1248/-31-3p/-182-5p/-183-5p
let-7b-5p
held
stratify
based
profile.
Notably,
several
these
were
associated
presence
granulomas,
vasculitis
necrosis
patients.
Conclusion
Our
study
identifies
novel
putatively
implicated
pathogenesis
highlights
dysregulated
as
supporting
biomarkers
establishing
diagnosis,
particularly
early
phases
disease,
or
atypical
presentation.
Язык: Английский
Thromboangiitis obliterans: a review
International Surgery Journal,
Год журнала:
2024,
Номер
11(6), С. 1033 - 1040
Опубликована: Май 4, 2024
Buerger's
disease
was
initially
described
by
von
Winiwarter
in
1879
where
he
it
as
thromboangiitis
obliterans
(TAO),
detailing
the
case
of
spontaneous
gangrene
secondary
to
intimal
proliferation.
In
1908,
Leo
Buerger
published
a
complete
pathological
description
based
on
amputation
group
people
who
later
suffered
short-term
gangrene.
or
TAO
is
defined
non-atherosclerotic
inflammatory
vasculitis
that
affects
small
and
medium
vessels
(including
arteries
veins)
lower
upper
extremities.
Although
there
are
hypotheses
about
its
etiopathogenesis
such
association
with
exposure
tobacco,
few
biomedical
investigations
have
been
carried
out,
so
direct
causality
remains
unknown.
Diagnosis
continues
be
challenge,
since
findings
tend
non-specific
inconsistent
suspicion,
which
why
currently
ruling
out
other
causes
atherosclerosis
vasculopathies.
With
current
evidence,
many
types
treatments,
both
pharmacological
non-pharmacological,
cessation
tobacco
consumption
having
greater
evidence
results.
It
essential
strengthen
basic
research
well
clinical
trials
standardize
management
this
type
patient,
high
impact
quality
life.
Язык: Английский
Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases
MedComm,
Год журнала:
2024,
Номер
5(8)
Опубликована: Июль 15, 2024
Exosomes
are
nanoscale
vesicles
of
cellular
origin.
One
the
main
characteristics
exosomes
is
their
ability
to
carry
a
wide
range
biomolecules
from
parental
cells,
which
important
mediators
intercellular
communication
and
play
an
role
in
physiological
pathological
processes.
have
advantages
biocompatibility,
low
immunogenicity,
biodistribution.
As
researchers'
understanding
has
increased,
various
strategies
been
proposed
for
use
diagnosing
treating
diseases.
Here,
we
provide
overview
biogenesis
composition
exosomes,
describe
relationship
between
disease
progression,
focus
on
as
biomarkers
early
screening,
monitoring,
guiding
therapy
refractory
diseases
such
tumors
neurodegenerative
We
also
summarize
current
applications
especially
engineered
efficient
drug
delivery,
targeted
therapies,
gene
immune
vaccines.
Finally,
challenges
potential
research
directions
clinical
application
discussed.
In
conclusion,
emerging
molecule
that
can
be
used
diagnosis
treatment
diseases,
combined
with
multidisciplinary
innovative
solutions,
will
applications.
Язык: Английский
Exosome miRNA profile and mitigating effect of miR-23a-3p/Cul3 axis on apoptosis in the pathogenesis of SiO2 dust-induced lung fibrosis
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116971 - 116971
Опубликована: Авг. 30, 2024
Silicosis
is
an
irreversible
interstitial
lung
fibrosis
resulting
from
persistent
inflammation
induced
by
long-term
inhalation
of
SiO
Язык: Английский
Identification of the Neointimal Hyperplasia-Related LncRNA-mRNA-Immune Cell Regulatory Network in a Rat Carotid Artery Balloon Injury Model
Yuan Gou,
Anli Zhao,
Tao Qin
и другие.
International Heart Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Excessive
neointimal
hyperplasia
(NIH)
of
coronary
vessels
in
patients
is
the
main
cause
restenosis
(RS)
after
percutaneous
intervention
(PCI).
This
study
aimed
to
identify
regulatory
genes
related
NIH
a
rat
carotid
artery
balloon
injury
model.We
established
model
and
performed
RNA
sequencing
differentially
expressed
long
non-coding
RNAs
(DElncRNAs)
message
(DEmRNAs).
Immune
cells
were
analyzed
using
murine
Microenvironment
Cell
Population
counter.
The
Pearson
correlation
between
DEmRNAs,
DElncRNAs,
immune
was
analyzed,
followed
by
function
enrichment
analysis.
Core
DEmRNA
identified
Cytoscape.
Next,
core
lncRNAs-mRNAs-immune
cell
network
constructed.
NIH-related
gene
sets
from
Gene
Expression
Omnibus
GeneCards
databases
used
for
validation.A
total
2,165
DEmRNAs
705
DElncRNAs
tissue.
Four
key
screened
out,
including
mast
cells,
vessels,
endothelial
fibroblasts.
Based
on
4
246
93
obtained.
that
interact
with
lncRNAs
mainly
involved
cycle,
MAPK
signaling
pathway,
PI3K-Akt
pathway.
A
lncRNA-mRNA-immune
constructed,
9
mRNAs,
lncRNAs,
External
datasets
validation
confirmed
significant
both
these
mRNAs
NIH.In
this
study,
an
which
provided
clues
exploring
potential
mechanism
RS
cardiovascular
diseases.
Язык: Английский