Gels,
Год журнала:
2025,
Номер
11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Multifunctional
membranes
applied
to
biomedical
materials
become
attractive
support
the
biological
agents
and
increase
their
properties.
In
this
study,
biopolymeric
fibers
based
on
polycaprolactone
(PCL)
pectin
(PEC)
were
reinforced
with
faujasite
zeolite
(FAU)
for
cloxacillin
antibiotic
(CLX)
loading.
FAU
a
high
specific
surface
area
(347
±
8
m2
g-1),
crystallinity
particles
diameter
of
up
100
nm
produced
under
optimized
synthesis
conditions
(100
°C/4
h).
Zeolites
incorporated
into
polymeric
nanofibers
be
carrier
in
wound
treatment,
using
electrospinning
as
an
efficient
method.
The
showed
good
mechanical
resistance
incorporation
CLX
was
proven
by
assays
inhibit
growth
Staphylococcus
aureus
bacteria.
controlled
release
different
pH
conditions,
which
simulate
environment,
carried
out
229
h,
achieving
released
concentration
6.18
0.02
mg
L-1.
These
results
prove
that
obtaining
hybrid
fiber
(polymer-zeolite)
incorporate
drugs
manner
successfully
achieved.
bactericidal
activity
material
shows
its
use
measured
applications
could
alternative
conventional
methods.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
269, С. 132071 - 132071
Опубликована: Май 4, 2024
Wound
healing
is
a
challenging
clinical
problem
and
efficient
wound
management
essential
to
prevent
infection.
This
best
done
by
utilizing
biocompatible
materials
in
order
complete
the
rapid
manner,
with
functional
esthetic
outcomes.
In
this
context,
zein
protein
fulfills
criteria
of
ideal
dressing
which
include
non-toxicity
non-inflammatory
stimulation.
Zein
gels
containing
rutin
were
prepared
without
any
chemical
refinement
or
addition
gelling
agents
obtain
natural
formulation
characterized
antioxidant
anti-inflammatory
properties
be
proposed
for
treatment
burns
sores.
vitro
scratch
assay
showed
that
gel
formulations
promoted
cell
migration
gap
closure
within
24
h
(~90
%).
addition,
vivo
activities
rutin-loaded
greater
therapeutic
efficacy
Wistar
rats,
decrease
area
about
90
%
at
day
10
respect
free
form
bioactive
DuoDERM®.
The
evaluation
various
markers
(TNF-α,
IL-1β,
IL-6,
IL-10)
confirmed
effect
formulation.
results
illustrate
feasibility
exploiting
peculiar
features
wound-healing
purposes.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 599 - 626
Опубликована: Янв. 1, 2025
Silk
protein,
as
a
natural
polymer
material
with
unique
structures
and
properties,
exhibits
tremendous
potential
in
the
biomedical
field.
Given
limited
production
restricted
properties
of
silk
proteins,
molecular
biotechnology
has
been
extensively
applied
protein
genetic
engineering
to
produce
novel
proteins
specific
properties.
This
review
outlines
roles
major
model
organisms,
such
silkworms
spiders,
production,
provides
detailed
introduction
applications
gene
editing
technologies
(eg,
CRISPR-Cas9),
transgenic
expression
technologies,
synthetic
biology
techniques
engineering.
By
analyzing
factors
influencing
expression,
this
further
elaborates
on
innovative
drug
delivery
systems,
tissue
regenerative
medicine
skin,
bone,
cartilage,
vascular
repair),
well
antibacterial
immune
strategies.
Notably,
modified
expressed
by
demonstrate
significant
advantages
enhancing
bioavailability
promoting
cell
proliferation
differentiation.
In
conclusion,
engineering,
through
continuous
innovations
biotechnology,
provided
an
effective
pathway
for
high-performance
materials.
The
extensive
these
field
have
not
only
expanded
functionality
but
also
offered
new
approaches
address
medical
challenges.
future,
development
will
rely
interdisciplinary
integration
promote
in-depth
research
expansion
industrial
proteins.
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
ABSTRACT
Recently,
there
has
been
a
surge
in
scholarly
interest
regarding
the
application
of
sophisticated
materials
technology
to
expedite
wound
healing,
particularly
through
integration
nanocomposites
endowed
with
multifaceted
functionalities
augment
efficacy
care
products.
In
order
propose
an
external
power‐free
healing
dressing
electrical
stimulation
function,
polyvinylidene
fluoride
(PVDF)
nanofibers
incorporating
graphene
oxide
(GO)
at
varying
concentrations
were
fabricated
via
electrospinning
technique.
Scanning
electron
microscopy
(SEM)
was
employed
reveal
morphology
composite
nanofibers.
Fourier
transform
infrared
(FTIR)
spectroscopy
and
X‐ray
diffraction
(XRD)
analyses
confirmed
transition
PVDF
from
α
phase
β
phase.
The
antibacterial
PVDF/GO
against
Staphylococcus
aureus
rigorously
examined.
Results
indicated
marked
enhancement
correlation
increasing
content
GO.
Moreover,
piezoelectric
property
assessments,
cytotoxicity,
hemolysis
tests
meticulously
performed.
outcomes
suggested
that
containing
0.5
w/w%
GO
(PVDF/GO‐0.5)
demonstrated
superior
performance
across
all
evaluated
metrics,
terms
mechanical
properties,
characteristics,
efficacy.
These
findings
imply
PVDF/GO‐0.5
possess
capability
mimic
endogenous
electric
field,
which
is
beneficial
boost
cellular
migration
proliferation,
thereby
accelerating
process.
Overall,
innovative
proposed
this
study
can
be
considered
highly
promising
candidate
field
tissue
engineering.
