Zein-based nanoparticulate systems: a journey through fabrication, targeting strategies and biomedical applications

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 48

Опубликована: Янв. 2, 2025

Zein, a plant-based protein obtained from the endosperm of corn (

Язык: Английский

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Development and Characterization of Niaprazine-Loaded Xanthan Gum-Based Gel for Oral Administration

Gels, Год журнала: 2025, Номер 11(2), С. 101 - 101

Опубликована: Фев. 1, 2025

Niaprazine is a sedative-hypnotic drug initially developed as an antihistamine and used for its notable sedative effects, particularly in children. Following withdrawal from the market by producer, has been administered magistral formulations available syrup form, but there are several important disadvantages to this, including instability, taste issues, lack of controlled release, potential unreliable dosing due incomplete swallowing. There also increased risk dental caries, well fact that these not suitable children who suffer diabetes. The purpose current investigation prepare characterize xanthan gum-based gels oral administration niaprazine. appear transparent-whiteish, non-sticky substances, with uniformly dispersed throughout systems. They stable over time. Dynamic rheology revealed their advantageous shear-thinning properties, which enable formulation be flexibly dosed orally through via syringe. During experimentation, evaluation mucoadhesion features vitro release profile were performed. results demonstrate may represent alternative niaprazine syrup, allowing easy preparation, administration, compliance various categories patients, pediatric.

Язык: Английский

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Poloxamer 407-Based Hydrogels Containing Rutin Increase the In Vitro and In Vivo Wound Healing Phenomena

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Rutin is a flavonoid glycoside found in many plants, known for its various pharmacological properties. However, therapeutic potential limited by low water solubility, which restricts bioavailability. Poloxamer 407 (P407) multifunctional excipient, has proven effective delivering poorly water-soluble drugs and promoting the healing process. Based on this information, study investigates wound of rutin-loaded P407 hydrogels, as an innovative pharmaceutical formulation. In vitro scratch assays human keratinocytes revealed that combining rutin with significantly enhances cell proliferation compared to single components. Moreover, proposed hydrogel improved more effectively rats than free drug or commercial dressing DuoDERM. Histological analyses confirmed formulation increased epithelialization collagen synthesis injured epidermises. These findings provide strong rationale use hydrogels treatment skin injuries.

Язык: Английский

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Concanavalin-conjugated zinc-metal-organic framework drug for pH-controlled and targeted therapy of wound bacterial infection

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134637 - 134637

Опубликована: Авг. 10, 2024

Язык: Английский

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Trends in Protein Derived Materials for Wound Care Applications

Biomaterials Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Natural resource based polymers, especially those derived from proteins, have attracted significant attention for their potential utilization in advanced wound care applications. Protein materials provide superior biocompatibility, biodegradability, and other functionalities compared to conventional dressings. The effectiveness of various fabrication techniques, such as electrospinning, phase separation, self-assembly, ball milling, is examined the context developing protein-based healing. These methods produce a wide range forms, including hydrogels, scaffolds, sponges, films, bioinspired nanomaterials, each designed specific types wounds different stages This review presents comprehensive analysis recent research that investigates transformation proteins into healing Our focus on essential keratin, collagen, gelatin, silk, zein, albumin, we emphasize distinct traits roles management. Protein-based show promising biomedical engineering, offering improved capabilities reduced risks infection. It crucial explore use these clinical settings while also addressing challenges may arise commercialization future.

Язык: Английский

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The Formation Mechanism of Zein Gel Induced by Amyloid-like Fibrils

Food Hydrocolloids, Год журнала: 2024, Номер unknown, С. 110926 - 110926

Опубликована: Дек. 1, 2024

Язык: Английский

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