Tragacanth gum hydrogels with cellulose nanocrystals: A study on optimizing properties and printability

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136182 - 136182

Опубликована: Сен. 1, 2024

Язык: Английский

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An overview of flexible sensing nanocomposites

Advanced Composites and Hybrid Materials, Год журнала: 2024, Номер 7(5)

Опубликована: Сен. 13, 2024

Язык: Английский

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Influence of Cell Geometry on the Mechanical and Failure Characteristics of 3D Voronoi Hydroxyapatite Through the Stereolithography Technique

Ceramics, Год журнала: 2025, Номер 8(1), С. 4 - 4

Опубликована: Янв. 4, 2025

This study investigates the design and mechanical evaluation of hydroxyapatite (HAp) scaffolds for bone tissue engineering, using stereolithography (SLA) to fabricate homogeneous hollow elongated Voronoi structures. HAp, known its biocompatibility biodegradability, was selected create with a structure that supports cell growth. Both scaffold designs were tested under compression measure key properties, including compressive strength, Young’s modulus, stiffness, energy absorption. The demonstrated superior achieving maximum load 913.6 N at displacement 0.166 mm stiffness 5162.8 N/mm, indicating higher load-bearing capacity absorption compared design. Despite these strengths, failure analysis revealed early fractures strut junctions, particularly in slender areas, leading fluctuations load–displacement curve suggesting risk neighboring tissues practical applications. These findings underscore potential Voronoi-based orthopedic use, while also highlighting need structural refinements improve durability clinical effectiveness.

Язык: Английский

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Chitosan/alginate polyelectrolyte complex hydrogels by additive manufacturing for in vitro 3D ovarian Cancer modeling

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139795 - 139795

Опубликована: Янв. 1, 2025

Язык: Английский

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Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106633 - 106633

Опубликована: Янв. 1, 2025

Язык: Английский

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Osteochondral Tissue Engineering: Scaffold Materials, Fabrication Techniques and Applications

Biotechnology Journal, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

ABSTRACT Osteochondral damage, caused by trauma, tumors, or degenerative diseases, presents a major challenge due to the limited self‐repair capacity of tissue. Traditional treatments often result in significant trauma and unpredictable outcomes. Recent advances bone/cartilage tissue engineering, particularly scaffold materials fabrication technologies, offer promising solutions for osteochondral regeneration. This review highlights selection design scaffolds using natural synthetic such as collagen, chitosan (Cs), polylactic acid (PLA), alongside inorganic components like bioactive glass nano‐hydroxyapatite (nHAp). Key techniques—freeze‐drying, electrospinning, 3D printing—have improved porosity mechanical properties. Special focus is placed on multiphasic that mimic structures, promoting cell adhesion differentiation supporting regeneration cartilage subchondral bone. In addition, current obstacles future directions regenerating damaged tissues will be discussed.

Язык: Английский

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Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Язык: Английский

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Gels as Promising Delivery Systems: Physicochemical Property Characterization and Recent Applications

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 249 - 249

Опубликована: Фев. 14, 2025

Gels constitute a versatile class of materials with considerable potential for applications in both technical and medical domains. Physicochemical property characterization is critical evaluation method gels. Common techniques include pH measurement, structural analysis, mechanical assessment, rheological phase transition studies, among others. While numerous research articles report results, few reviews comprehensively summarize the appropriate numerical ranges these properties. This lack standardization complicates harmonized methods hinders direct comparisons between different To address this gap, it essential to systematically investigate analyze data from extensive body literature on In review, we provide comprehensive summary general present detailed analysis gel support future promote standardized protocols.

Язык: Английский

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Mechanics of surface wave propagation in a pre‐stressed and functionally graded piezoelectric‐hydrogel‐viscoelastic composite layered structure

ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, Год журнала: 2025, Номер 105(3)

Опубликована: Март 1, 2025

Abstract This study introduces a mathematics‐based mechanics framework to analyze the surface wave propagation in pre‐stressed and functionally graded composite structure while focusing on internal field variables evolution, such as stress field. It further explores potential shear deformation of composite, which comprises hydrogel layer bonded between piezoelectric material viscoelastic substrate, effectively representing micro‐electro‐mechanical system. Time‐dependent force balance equations ‐direction Maxwell's for electric are solved within each domain, leading general analytical solution. Two sets boundary conditions, considering influence inter‐layer adhesive macro‐scale equilibrium, resulting separate solutions medium using mode method. The final system is classical Newton‐Raphson method by uncoupling coupled equations. examines impact various parameters variable distribution, highlighting nature proposed concluded that gradient factors, pre‐stress, fixed‐charge concentration pH‐sensitive significantly propagation, severe distortion specific plane. approach offers novel insights into multi‐layered systems has applications design vibration‐damping foundations, seismic isolation systems, MEMS devices.

Язык: Английский

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Perfusable cellulose channels from decellularized leaf scaffolds for modeling vascular amyloidosis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142509 - 142509

Опубликована: Март 1, 2025

Язык: Английский

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