Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review

Biomolecules, Год журнала: 2024, Номер 14(7), С. 789 - 789

Опубликована: Июль 3, 2024

Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.

Язык: Английский

---

Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9524 - 9524

Опубликована: Сен. 1, 2024

Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber

Язык: Английский

---

Electrospun chitosan//ethylcellulose-vitamin E//ethylcellulose-curcumin tri-chamber eccentric Janus nanofibers for a joint antibacterial and antioxidant performance

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 135753 - 135753

Опубликована: Окт. 17, 2024

Язык: Английский

---

Fabrication of Aligned Polyhydroxybutyrate Fibrous Scaffolds via a Touchspinning Apparatus

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Язык: Английский

---

Nanofibers in Glioma Therapy: Advances, Applications, and Overcoming Challenges

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4677 - 4703

Опубликована: Апрель 1, 2025

Despite relentless effort to study glioma treatment, the prognosis for patients remains poor. The main obstacles include high rate of recurrence and difficulty passing blood-brain barrier (BBB) therapeutic drugs. Nanomaterials owing their special physicochemical properties have been used in a wide range fields thus far. nanodrug delivery system (NDDS) with ability crossing BBB, targeting site, maintaining drug stability controlling release, has significantly enhanced anti-tumor effect, improving patients. Aligned nanofibers (NFs) are ideal materials establish vitro models microenvironment (GME), enabling exploration mechanism cell migration invasion discover novel targets. Moreover, NFs now widely applications such as radiotherapy, phototherapy, thermotherapy immunotherapy. absolute dominance anti-glioma applications, there still some problems further optimization NDDS, impact interactions between protein corona (PC) on therapy. This paper will shed light latest systems mimicking tumor (TME), discuss how optimize NDDS eliminate or utilize nanomedicine-PC interactions.

Язык: Английский

---

Biopolymer based Fibrous Aggregate Materials for Diagnosis and Treatment: Design, Manufacturing, and Applications

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Abstract Biopolymer‐based fibrous aggregate materials (BFAMs) have gained increasing attention in biomedicine due to their excellent biocompatibility, processability, biodegradability, and multifunctionality. Especially, the medical applications of BFAMs demand advanced structure, performance, function, which conventional trial‐and‐error methods struggle provide. This necessitates rational selection manufacturing design with various intended functions structures. review summarizes current progress raw material selection, structural functional design, processing technology, application BFAMs. Additionally, challenges encountered during development are discussed, along perspectives for future research offered.

Язык: Английский

---

Progress in Preparation, Modification and Application of Electrospun Nanofiber Materials in Bone Tissue Engineering

Polymer-Plastics Technology and Materials, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Май 26, 2025

Язык: Английский

---

Micro- and nano-fibers for organ-on-a-chip: Construction, applications, and prospects

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101322 - 101322

Опубликована: Ноя. 1, 2024

Язык: Английский

---

Cold Plasma Technology: A Cutting-Edge Approach for Enhancing Shrimp Preservation

Heliyon, Год журнала: 2024, Номер 10(23), С. e40460 - e40460

Опубликована: Ноя. 15, 2024

Cold plasma (CP) is an emerging technology employed to safeguard highly perishable food items, particularly aquatic products such as shrimp. Due its significant amount of moisture, superior protein composition that contains important amino acids, and unsaturated fatty acid content, shrimp are susceptible microbial deterioration overall alterations in their physical chemical characteristics. Such spoilage not only diminishes the nutritional value but also has potential generate harmful substances, rendering it unsuitable for consumption. Recent observations have indicated a growing market demand maintains quality prolonged shelf life. Furthermore, there emphasis on production items undergo minimal processing or nonthermal preservation methods. Extensive documentation exists regarding efficacy CP eliminating microorganisms from without inducing resistance activating enzymes contribute spoilage. Therefore, can be mentioned slight interference preserve quality. This chapter primarily explores principles methods technology, well impact melanosis, physicochemical changes, sensory properties,

Язык: Английский

---

Combining Electrospinning and Photoinduced Reactions to Fabricate Cytocompatible and Antibacterial Ag Nanoparticle-Decorated Polymeric Membranes

ACS Applied Polymer Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 30, 2024

Язык: Английский

---