Characterization of insulin and bile acid complexes in liposome by different mass spectrometry techniques

Analytical and Bioanalytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

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Bioavailability Enhancement and Formulation Technologies of Oral Mucosal Dosage Forms: A Review

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 148 - 148

Опубликована: Янв. 22, 2025

The oral mucosa is a versatile surface for drug administration, supporting both local and systemic therapies. Many active substances are effectively absorbed in the cavity, offering an alternative to enteral administration by bypassing harsh gastrointestinal environment hepatic first-pass metabolism. This has made mucosal delivery growing area of research. Enhancing bioavailability ingredients key focus pharmaceutical technology, especially given challenges developing new drugs. Numerous strategies improve compatible with delivery, unique anatomy cavity enabling specialized applications. A variety dosage forms tailored meet therapeutic needs while addressing biopharmaceutical patient compliance challenges. Proper formulation can achieve controlled release, improved bioavailability, convenience. review highlights potential focusing on enhancement methods types production technologies optimized use cavity.

Язык: Английский

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Application or function of cyclodextrin in insulin and cell delivery for efficient diabetic treatment

Hybrid Advances, Год журнала: 2025, Номер unknown, С. 100462 - 100462

Опубликована: Апрель 1, 2025

Язык: Английский

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Retrospective Case‐Cohort Study on Risk Factors for Developing Distant Metastases in Women With Breast Cancer

Cancer Medicine, Год журнала: 2025, Номер 14(8)

Опубликована: Апрель 1, 2025

ABSTRACT Objective This study aimed to identify risk factors associated with the development of metastases in breast cancer patients, investigate survival rates, and relationship between local recurrences distant metastases. Methods retrospective case‐cohort included women who were treated at a certified Breast Unit 2001 2015. Cases developed compared controls based on diagnosis year, stage, age diagnosis. Comprehensive information patient characteristics, tumor biology, treatment options was gathered. Results The 412 patients 433 remained metastasis‐free over median follow‐up 150 months (interquartile range 87–202). 20‐year overall 99.23% for control group 23.62% those metastasis ( p < 0.01). Significant lobular invasive carcinoma (odds ratio (OR) 2.26, 0.001), triple‐negative subtype (OR 4.06, = 0.002), high grade 2.62, 0.004), larger size 1.02, lymph node involvement loco‐regional recurrence 4.32, 0.001). Progesterone receptor (PR) expression protective 0.52, 95% confidence interval 0.34–0.81, 0.003). Machine learning models supported these findings, though their clinical significance limited. Conclusions Lobular carcinoma, specific subtypes, grade, large size, involvement, are all significant metastasis, whereas PR is protective. potential machine predicting explored, showing promise future personalized assessment.

Язык: Английский

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β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Abstract Innate immune cells such as macrophages and dendritic play major roles in the progression of many cancerous, fibrotic, autoimmune diseases, often due to environmental cues that skew these toward a phenotype progresses or exacerbates disease state. As such, growing focus treating diseases is placed on exploiting high plasticity modify reverse their pro‐disease phenotypes using immunomodulatory materials. β‐1,3 glucans are one type material has exhibited diverse effects cells, including mitigation reversal adverse dysregulated cells. In this review, we outline various fabrication techniques produce glucan‐derived microparticles nanoparticles discuss particle properties can be obtained by tuning glucan chemistry, method, formulation components. Furthermore, applications particles highlighted with cell targeting, modulation, delivery small molecule macromolecular therapeutics.

Язык: Английский

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Development and Evaluation of the Biological Activities of a Plain Mucoadhesive Hydrogel as a Potential Vehicle for Oral Mucosal Drug Delivery

Gels, Год журнала: 2024, Номер 10(9), С. 574 - 574

Опубликована: Сен. 3, 2024

This study aimed to develop HGs based on cationic guar gum (CGG), polyethylene glycol (PEG), propylene (PG), and citric acid (CA) using a 2

Язык: Английский

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