Challenges and considerations in liposomal hydrogels for the treatment of infection

Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Янв. 10, 2025

Liposomal hydrogels are novel drug delivery systems that comprise preformed liposomes incorporated in destined for mostly localized therapy, herewith antimicrobial therapy. The formulation benefits from versatility of as lipid-based nanocarriers enable various antimicrobials different lipophilicities, and secondary vehicle, hydrogel, assures better retention time at the infection site. Especially an era alarming resistance, efficient therapy avoids systemic exposure related side effects is crucial. We provide overview liposomal were developed superior infections sites, with focus on skin vaginal infections. review summarizes challenges site most common infection-causing pathogens offers commentary relevant features needs to optimize increase outcome. discuss impact composition, size, choice polymer-forming hydrogel outcome based literature own experience field. offer improved By fine-tuning well properties, formulations performance can be optimized targeting specific

Язык: Английский

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Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

Skin wound healing is a complex physiological process that involves many different cell types and signaling molecules. In traditional Chinese medicine, A. membranaceus Panax notoginseng are commonly used together for the treatment of injury their significant efficacy. The application new materials may make -P. (AP) play better curative effect. this study, we fabricated Carboxymethyl chitosan-Sodium alginate hydrogel loaded with extract Astragalus - P. (APCS), which showed favorable stability, biocompatibility, ability to rapidly release drugs. Cell culture experiments demonstrated APCS dramatically increased fibroblast proliferation, migration, differentiation into myofibroblast. vivo on SD rats hydrogels significantly accelerated skin healing, reduced inflammatory response, enhanced formation blood vessels, granulation tissues, collagen fibers, promoted re-epithelialization at site. Increased expression catalase, VEGF, PGP9.5 tissue indicated inhibited oxidative stress vascular neuronal regeneration. summary, displayed great potential as dressing achieving satisfactory full-thickness wounds.

Язык: Английский

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Multi-functional bioactive hydrogel based on CCM-Co-ZIF-8 nanoparticles for chronic wound healing: Synergistic antibacterial, antioxidant, and anti-inflammatory therapy

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113824 - 113824

Опубликована: Фев. 1, 2025

Язык: Английский

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Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2025, Номер unknown, С. 159613 - 159613

Опубликована: Апрель 1, 2025

Язык: Английский

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Multifunctional carboxymethyl chitosan/oxidized carboxymethyl cellulose hydrogel loaded with ginsenoside Rg1 and polydopamine nanoparticles for infected diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136686 - 136686

Опубликована: Окт. 1, 2024

Язык: Английский

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Carboxymethyl chitosan/peach gum polysaccharide packaging film incorporating Citrus sinensis essential oil effectively enhances the quality preservation of strawberries

Food Packaging and Shelf Life, Год журнала: 2024, Номер 46, С. 101409 - 101409

Опубликована: Ноя. 30, 2024

Язык: Английский

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