Bioactive compounds from sea sponges in Tobago exhibit growth inhibitory activity against Staphylococcus aureus and Escherichia coli compared to Amoxiclav
Journal of Taibah University for Science,
Год журнала:
2025,
Номер
19(1)
Опубликована: Фев. 10, 2025
Язык: Английский
Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea
Journal of Natural Products,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Sponges
of
the
genus
Neopetrosia
are
known
for
production
a
large
diversity
bioactive
metabolites.
Contignasterines
A
(1)
and
B
(2)
were
isolated
as
major
metabolites
sponge
cf.
rava
collected
in
Bismarck
Sea
along
with
highly
steroid
contignasterol
(3)
possessing
similar
oxidized
aglycone.
characterized
by
presence
2-aminoimidazole
branched
on
side-chains
steroid,
1
also
contains
an
unusual
phosphate
group
at
C-7.
The
anti-inflammatory
activities
these
compounds
investigated
revealed
that
all
three
inhibited
pro-inflammatory
mediators.
Язык: Английский
Harnessing marine antimicrobial peptides for novel therapeutics: A deep dive into ocean-derived bioactives
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
307, С. 142158 - 142158
Опубликована: Март 17, 2025
Язык: Английский
Recent Advances in Marine-Derived Bioactives Towards Cancer Therapy
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(4), С. 740 - 781
Опубликована: Дек. 6, 2024
The
increase
in
cancer
incidence
recent
years
necessitates
urgent
exploration
of
novel
and
alternative
sources
natural
bioactives
for
targeted
therapy.
Approximately
75%
the
Earth’s
surface
is
covered
by
oceans,
which
are
thought
to
harbor
untapped
physiologically
active
compounds
with
potential
efficacy
against
cancer.
Recently,
a
growing
focus
has
been
on
isolating
investigating
bioactive
derived
from
marine
sources.
Bioactive
metabolites
diverse
chemical
structures,
isolated
various
species
such
as
algae,
mollusks,
actinomycetes,
demonstrate
wide
range
cancers.
To
our
knowledge,
this
one
articles
that
reviewed
papers
application
marine-derived
This
study
aims
showcase
some
most
current
developments
therapy
have
identified
Язык: Английский
Bioactive Compounds Isolated from a Marine Sponge Selectively Inhibit Neisseria gonorrhoeae
Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1229 - 1229
Опубликована: Дек. 19, 2024
Background/Objectives:
Neisseria
gonorrhoeae
is
the
third
most
common
sexually
transmitted
infection
(STI),
which
may
become
untreatable
soon
if
resistance
continues
to
drastically
increase.
Due
increases
in
recommended
antibiotics,
alternative
sources
of
novel
compounds
combat
this
threat
are
being
explored.
Interestingly,
marine
sponges
have
proven
produce
a
plethora
bioactive
that
display
anticancer,
antiviral,
antifungal,
and
antibacterial
activity.
Methods:
In
study,
extracts
sponge
collected
from
Saint
Thomas,
US
Virgin
Islands
were
examined
determine
their
activity
against
E.
coli,
S.
aureus,
N.
gonorrhoeae.
Results:
The
ethyl
acetate
significantly
inhibited
growth
gonorrhoeae,
while
none
aureus
coli.
bioassay-guided
purification
extract
resulted
isolation
6-desmethyl-6-ethylspongosoritin
A
(1)
plakortone
B
(2).
To
pure
metabolite
could
improve
efficacy
ceftriaxone
high-level
(HTX)-resistant
gonococcal
strain,
an
antibiotic
checkerboard
assay
was
done
by
combining
various
concentrations
either
precursor
fractions
or
purified
compound
2
with
ceftriaxone.
Plakortone
(2)
acted
synergy
strains
increasing
membrane
permeability
when
exposed
for
4
h
24
h.
Conclusions:
This
suggests
serve
as
source
antibiotic-resistant
well
currently
prescribed
antibiotics.
Язык: Английский