Vanillin and IGF1-loaded dual-layer multifunctional wound dressing with micro-nanofibrous structure for full-thickness wound healing acceleration

International Journal of Pharmaceutics, Год журнала: 2025, Номер 671, С. 125231 - 125231

Опубликована: Янв. 15, 2025

Язык: Английский

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Antibacterial and osteogenic properties of chitosan-polyethylene glycol nanofibre-coated 3D printed scaffold with vancomycin and insulin-like growth factor-1 release for bone repair

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139883 - 139883

Опубликована: Янв. 1, 2025

Язык: Английский

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Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 30, 2025

Язык: Английский

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Incorporation of forsterite nanoparticles in a 3D printed polylactic acid/polyvinylpyrrolidone scaffold for bone tissue regeneration applications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141046 - 141046

Опубликована: Фев. 1, 2025

Язык: Английский

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Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 6, 2025

Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloyl (GelMA), Panax notoginseng saponins (PNS), sodium alginate microspheres encapsulating insulin-like growth factor-1 (IGF-1). This was engineered to achieve gradient sustained release bioactive agents target senescence promote vascular repair. In vitro studies demonstrated the significantly reduced oxidative stress, suppressed markers senescence-associated secretory phenotypes, restored endothelial cell function under high-glucose conditions by inhibiting NF-κB pathway activation. Transcriptomic analysis revealed modulation pathways linked inflammation, apoptosis, angiogenesis. accelerated diabetic closure in rat model vivo enhanced collagen deposition, granulation tissue formation, neovascularization. Furthermore, mitigated stress promoted remodelling. The synergistic effects PNS IGF-1 within established pro-regenerative microenvironment both pathological ageing dysfunction. These findings highlight GelMA/PNS/Alg@IGF-1 as promising therapeutic platform for management, this material offers dual anti-senescence proangiogenic efficacy overcome complexities healing.

Язык: Английский

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A multiple-crosslinked injectable hydrogel for modulating tissue microenvironment and accelerating infected diabetic wound repair

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 18, 2025

Язык: Английский

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Multifunctional polymeric wound dressings

Polymer Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

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Keratin-TMAO dressing accelerates full-thickness skin wound healing in diabetic rats via M2-macrophage polarization and the activation of PI3K/AKT/mTOR signaling pathway

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143313 - 143313

Опубликована: Апрель 1, 2025

Язык: Английский

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Fabrication and characterization of an asymmetric bilayer wound dressing for healing acceleration of full thickness wounds

International Journal of Pharmaceutics, Год журнала: 2025, Номер 676, С. 125638 - 125638

Опубликована: Апрель 23, 2025

Язык: Английский

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