The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance DOI Creative Commons
Xintong Lyu, Yangyang Yu, Yuanjun Jiang

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 15(3), С. 101141 - 101141

Опубликована: Ноя. 8, 2024

Mitochondria play a crucial role as organelles, managing several physiological processes such redox balance, cell metabolism, and energy synthesis. Initially, the assumption was that mitochondria primarily resided in host cells could exclusively transmit from oocytes to offspring by mechanism known vertical inheritance of mitochondria. Recent scholarly works, however, suggest certain types their other developmental via referred intercellular or horizontal mitochondrial transfer. This review details process which are transferred across explains impact transfer between on efficacy functionality cancer various forms. Specifically, we regulating cellular metabolism restoration, excess reactive oxygen species (ROS) generation, proliferation, invasion, metastasis, mitophagy activation, DNA (mtDNA) inheritance, immune system modulation therapeutic resistance cancer. Additionally, highlight possibility using approach treat enhance treatments.

Язык: Английский

Stroke Studies in Large Animals: Prospects of Mitochondrial Transplantation and Enhancing Efficiency using Hydrogels and Nanoparticle-assisted Delivery DOI
Öner Ülger, Ismail Eş, Christopher M. Proctor

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102469 - 102469

Опубликована: Авг. 25, 2024

Язык: Английский

Процитировано

3

Metabolic Crosstalk between Platelets and Cancer: Mechanisms, Functions, and Therapeutic Potential DOI
Zhixue Chen, Xu Lin, Yuan Yu

и другие.

Seminars in Cancer Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration DOI Creative Commons

Xuri Chen,

Yunting Zhou, Wenyu Yao

и другие.

Bone Research, Год журнала: 2025, Номер 13(1)

Опубликована: Март 17, 2025

Abstract Mitochondria are vital organelles whose impairment leads to numerous metabolic disorders. Mitochondrial transplantation serves as a promising clinical therapy. However, its widespread application is hindered by the limited availability of healthy mitochondria, with dose required reaching up 10 9 mitochondria per injection/patient. This necessitates sustainable and tractable approaches for producing high-quality human mitochondria. In this study, we demonstrated highly efficient mitochondria-producing strategy manipulating mitobiogenesis tuning organelle balance in mesenchymal stem cells (MSCs). Utilizing an optimized culture medium (mito-condition) developed from our established formula, achieved 854-fold increase production compared normal MSC within 15 days. These were not only significantly expanded but also exhibited superior function both before after isolation, ATP levels 5.71 times that Mechanistically, revealed activation AMPK pathway establishment novel cellular state ideal mitochondrial fabrication, characterized enhanced proliferation while suppressing other energy-consuming activities. Furthermore, vivo these was validated mitotherapy mouse osteoarthritis model, resulting significant cartilage regeneration over 12-week period. Overall, study presented new off-the-shelf fabrication provided insights into molecular mechanisms governing synthesis.

Язык: Английский

Процитировано

0

Mitochondrial dysfunction in cardiovascular disease: investigating therapeutic approaches to enhance patient outcomes DOI Creative Commons
Omar Elsaka

MGM Journal of Medical Sciences, Год журнала: 2025, Номер 12(1), С. 127 - 135

Опубликована: Янв. 1, 2025

Abstract Mitochondria, the energy-generating organelles, undergo continuous biosynthesis, fission, fusion, and degradation cycles to maintain structural integrity. While mitochondria in adult heart are relatively static, their modifications, governed by mitochondrial morphology, crucial for energy production, organelle shape, stress adaptation. Mitochondrial fusion is mediated proteins such as Mitofusin 1 (Mfn1), 2 (Mfn2), Optic Atrophy (Opa1), which interact with endoplasmic reticulum, enhance mitophagy, remodel cristae, regulate apoptosis. In contrast, driven like dynamin-related protein (Drp1), fission (Fis1), factor (Mff), dynamics 49/51 (MiD49/51), facilitates elimination of damaged supports cell division. Dysregulated contribute various cardiac conditions, including hypertrophy, failure, ischemia/reperfusion injury. Also, dysfunction oxidative implicated atherosclerosis, hypertension, pulmonary hypertension. Modulating presents a promising therapeutic approach disorders. This study explores morphology disease, highlighting key regulatory genes involved potential targets.

Язык: Английский

Процитировано

0

Platelets: Emerging as a Cutting-Edge Source for Mitochondrial Transplantation in Rodent Models of Traumatic Brain Injury DOI
Chia Bamshad,

Zahra Pourmohammadi-Bejarpasi,

Fatemeh Amiri

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Abstract Traumatic brain injury (TBI) remains a significant clinical challenge due to the absence of effective therapies for mitigating oxidative damage and neuronal dysfunction. Given brain’s high metabolic demand, mitochondrial transplantation has emerged as promising therapeutic strategy. However, identifying an optimal, functional source mitochondria major obstacle. In this study, we explore potential isolated from senescent platelets readily available, GMP-compliant promoting recovery in TBI models. was induced rats using weight-drop model, with confirmation through histopathological analysis. The animals were then divided into four experimental groups: healthy control, TBI, + RB (receiving respiration buffer), Mito transplantation). Neurobehavioural assessed series sensorimotor tests, including beam walk test, horizontal bars grid-walking cylinder test. Our results show that significantly improved neurobehavioural function animals, performance group comparable control group. Histological examination further revealed tissue morphology closely resembled These findings provide compelling evidence platelet-derived accessible treatment TBI. investigation is needed determine long-term efficacy underlying mechanisms novel approach.

Язык: Английский

Процитировано

0

Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury DOI Creative Commons

Xiaochun Xiong,

Chao Zhou, Yijun Yu

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 52, С. 441 - 450

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Therapeutic implications of mitochondrial transfer on stem cell fate in regenerative medicine DOI Creative Commons
Ying Liu, Waruna Lakmal Dissanayaka,

Cynthia Kar Yung Yiu

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Май 21, 2025

With the discovery of intercellular mitochondrial transfer, intricate regulatory networks on stem cell fate have aroused intense academic interest. Apart from capturing freely released mitochondria donor cells, cells are able to receive through tunneling nanotubes (TNTs), gap junctional channels (GJCs) and extracellular vesicles (EVs), especially when undergoing stressful conditions such as inflammation, hypoxia, chemotherapy drug exposure, irradiation. Stem that potentiated by exogenous show enhanced potential for proliferation, differentiation, immunomodulation. The well-tolerated nature either autogenous or allogenous locally injected in human ischemic heart has validated safety therapeutic transplantation. In children diagnosed with DNA deletion syndrome, functional improvements been observed empowering their hematopoietic maternally derived mitochondria. widely investigated applications transfer ischemia-reperfusion injury, neurodegenerative diseases etc., potentials tissue repair regeneration equally noteworthy, though there no systematic summary this regard.This review analyzed research development trends regenerative medicine over past decade a bibliometric perspective, introduced concept associated mechanisms summarized regulations fate. Finally, application transplantation reviewed, including recent clinical studies related transplantation.Mitochondrial shows promise modifying reshaping cellular properties making them more conducive regeneration. Mesenchymal (MSCs)-derived shown multifaceted promoting revitalization cardiac, cutaneous, muscular, neuronal tissue. This integrates novel findings biology medicine, emphasizing crucial translational value It serves underscore significant impact provides valuable reference further exploration field.

Язык: Английский

Процитировано

0

The importance of platelet-derived mitochondrial transplantation in ischemic heart disease: A clinical study DOI
Gökhan Burçin Kubat

International Journal of Cardiology, Год журнала: 2024, Номер 412, С. 132312 - 132312

Опубликована: Июнь 29, 2024

Язык: Английский

Процитировано

2

The importance of platelet-derived mitochondrial transplantation in ischemic heart disease: A clinical study DOI

Nima Najafi-Ghalehlou,

Fatemeh Baharvand,

Zahra Pourmohammadi-Bejarpasi

и другие.

International Journal of Cardiology, Год журнала: 2024, Номер 413, С. 132408 - 132408

Опубликована: Июль 27, 2024

Язык: Английский

Процитировано

1

Mitochondrial Transplantation: Adaptive Bio-enhancement DOI Creative Commons

X. Lu,

Yong Jiang

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Abstract Mitochondria, known as the powerhouse of cell, are essential for cellular energy production. Dysfunction in mitochondrial function can significantly affect various organs. Transplanting healthy mitochondria enhance bioenergetics diseased cells and treat conditions, yet limits transplantation still unknown. Our study reveals that source transplanted is not restricted by species, recipient show no significant immune response to from different lineages. We also found metabolic compatibility between exogenous crucial, transplanting species endow with distinct characteristics combat diseases. Furthermore, our data indicate there competition among varying functions, more powerful yielding better therapeutic effects. Notably, we have an upper limit bio-enhancement provided mitochondria. research proposes a feasible path human through transplantation—adaptive bio-enhancement. Mitochondrial highly clinically valuable technique. I further expanded variety sources demonstrated potential adaptively biological functions.

Язык: Английский

Процитировано

1