Laser
interstitial
thermotherapy
has
shown
potential
in
the
treatment
of
inoperable
lung
cancers,
which
make
up
70-80
%
all
cases,
thanks
to
possibility
real-time
ultrasound
guidance,
a
fine
introducer
needle,
and
faster
recovery
after
procedure.
To
plan
laser
ablation
session
through
numerical
modeling,
sensitivity
analysis
input
parameters
is
necessary
since
simplifying
influential
could
lead
different
outcome.The
purpose
this
study
determine
laser-induced
ablated
volume,
an
indicator
therapy
efficacy,
with
regard
temperature
dependence
thermal
properties
clinical
power
ranges
(i.e.,
between
2
W
5
at
wavelength
1064
nm)
for
tissue.
According
results,
difference
volumes
derived
from
constant
temperature-dependent
grows
increasing
power,
reaching
17.5%
60.3%
under
ex
vivo
conditions
W,
respectively.
As
blood
perfusion
rate
strongly
affects
effects
tissue,
dependency
parameter
cannot
be
ignored.
The
assumption
valid
planning
by
acceptable
error
when
set
low
level,
e.g.,
~
2%
6%
3
W.Clinical
Relevance-The
methods
results
basis
defining
accurate
pre-planning
cancer.
Nano-based
drug
delivery
systems
hold
significant
promise
for
cancer
therapies.
Presently,
the
poor
accumulation
of
drug-carrying
nanoparticles
in
tumors
has
limited
their
success.
In
this
study,
based
on
a
combination
paradigms
intravascular
and
extravascular
release,
an
efficient
nanosized
system
with
programmable
size
changes
is
introduced.
Drug-loaded
smaller
(secondary
nanoparticles),
which
are
loaded
inside
larger
(primary
released
within
microvascular
network
due
to
temperature
field
resulting
from
focused
ultrasound.
This
leads
scale
decreasing
by
7.5
150
times.
Subsequently,
enter
tissue
at
high
transvascular
rates
achieve
higher
accumulation,
leading
penetration
depths.
response
acidic
pH
tumor
microenvironment
(according
distribution
oxygen),
they
begin
release
doxorubicin
very
slow
(i.e.,
sustained
release).
To
predict
performance
therapeutic
agents,
semi-realistic
first
generated
sprouting
angiogenesis
model
transport
agents
then
investigated
developed
multi-compartment
model.
The
results
show
that
reducing
primary
secondary
can
lead
cell
death
rate.
addition,
growth
be
inhibited
longer
time
enhancing
bioavailability
extracellular
space.
proposed
promising
clinical
applications.
Furthermore,
mathematical
applicable
broader
applications
systems.
Heliyon,
Год журнала:
2023,
Номер
9(11), С. e21227 - e21227
Опубликована: Окт. 20, 2023
The
past
decade
has
witnessed
a
breakthrough
in
novel
strategies
to
treat
cancer.
One
of
the
most
common
cancer
treatment
modalities
is
chemotherapy
which
involves
administering
anti-cancer
drugs
body.
However,
these
can
lead
undesirable
side
effects
on
healthy
cells.
To
overcome
this
challenge
and
improve
cell
targeting,
many
nanocarriers
have
been
developed
deliver
directly
cancerous
cells
minimize
tissues.
majority
research
studies
conclude
that,
using
encapsulated
much
safer
more
effective
alternative
than
delivering
drug
alone
its
free
form.
This
review
provides
summary
types
mainly
studied
for
delivery,
namely:
liposomes,
polymeric
micelles,
dendrimers,
magnetic
nanoparticles,
mesoporous
gold
carbon
nanotubes
quantum
dots.
In
review,
synthesis,
applications,
advantages,
disadvantages,
previous
nanomaterials
are
discussed
detail.
Furthermore,
future
opportunities
possible
challenges
translating
materials
into
clinical
applications
also
reported.
Focused
Ultrasound
(FUS)-triggered
nano-sized
drug
delivery,
as
a
smart
stimuli-responsive
system
for
treating
solid
tumors,
is
computationally
investigated
to
enhance
localized
delivery
of
and
treatment
efficacy.
Integration
thermosensitive
liposome
(TSL),
doxorubicin
(DOX)-loaded
nanocarrier,
FUS,
provides
promising
system.
A
fully
coupled
partial
differential
equations,
including
the
Helmholtz
equation
FUS
propagation,
bio-heat
transfer,
interstitial
fluid
flow,
transport
in
tissue
cellular
spaces,
pharmacodynamic
model
first
presented
this
approach.
Equations
are
then
solved
by
finite
element
methods
calculate
intracellular
concentration
The
main
objective
study
present
multi-physics
multi-scale
simulate
release,
transport,
followed
an
analysis
how
exposure
time
release
rate
affect
these
processes.
Our
findings
not
only
show
capability
replicate
therapeutic
approach,
but
also
confirm
benefits
with
improvement
aggregation
tumor
reduction
healthy
tissue.
For
instance,
survival
fraction
cells
after
dropped
62.4%,
because
large
amount
delivered
drugs
cancer
cells.
Next,
combination
three
rates
(ultrafast,
fast,
slow)
times
(10,
30,
60
min)
was
examined.
Area
under
curve
(AUC)
results
that
30
min
rapid
leads
practical
effective
response.
Cell
behavior
is
intricately
intertwined
with
the
in
vivo
microenvironment
and
endogenous
pathways.
The
ability
to
guide
cellular
toward
specific
goals
can
be
achieved
by
external
stimuli,
notably
electricity,
light,
ultrasound,
magnetism,
simultaneously
harnessed
through
biomaterial-mediated
responses.
These
triggers
become
focal
points
within
body
due
interactions
biomaterials,
facilitating
a
range
of
pathways:
electrical
signal
transmission,
biochemical
cues,
drug
release,
cell
loading,
modulation
mechanical
stress.
Stimulus-responsive
biomaterials
hold
immense
potential
biomedical
research,
establishing
themselves
as
pivotal
point
interdisciplinary
pursuits.
This
comprehensive
review
systematically
elucidates
prevalent
physical
stimuli
their
corresponding
biomaterial
response
mechanisms.
Moreover,
it
delves
deeply
into
application
domain
biomedicine.
A
balanced
assessment
distinct
stimulation
techniques
provided,
along
discussion
merits
limitations.
aims
shed
light
on
future
trajectory
stimulus-responsive
disease
treatment
outline
prospects
for
development.
poised
spark
novel
concepts
advancing
intelligent,
biomaterials.
Life,
Год журнала:
2024,
Номер
14(6), С. 672 - 672
Опубликована: Май 24, 2024
In
drug
development,
it
is
not
uncommon
that
an
active
substance
exhibits
efficacy
in
vitro
but
lacks
the
ability
to
specifically
reach
its
target
vivo.
As
a
result,
targeted
delivery
has
become
primary
focus
pharmaceutical
sciences.
Since
approval
of
Doxil®
1995,
liposomes
have
emerged
as
leading
nanoparticle
delivery.
Their
low
immunogenicity,
high
versatility,
and
well-documented
led
their
clinical
use
against
wide
variety
diseases.
That
being
said,
every
disease
accompanied
by
unique
set
physiological
conditions,
each
liposomal
product
must
be
formulated
with
this
consideration.
There
are
multitude
different
targeting
techniques
for
can
employed
depending
on
application.
Passive
such
PEGylation
or
enhanced
permeation
retention
effect
improve
general
pharmacokinetics,
while
conjugating
molecules
liposome
surface
may
bring
even
further
specificity.
This
review
aims
summarize
current
strategies
treatment
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июль 20, 2023
Computational
modeling
enables
researchers
to
study
and
understand
various
complex
biological
phenomena
in
anticancer
drug
delivery
systems
(DDSs),
especially
nano-sized
DDSs
(NSDDSs).
The
combination
of
NSDDSs
therapeutic
ultrasound
(TUS),
that
is,
focused
low-intensity
pulsed
ultrasound,
has
made
significant
progress
recent
years,
opening
many
opportunities
for
cancer
treatment.
Multiple
parameters
require
tuning
optimization
develop
effective
DDSs,
such
as
NSDDSs,
which
mathematical
can
prove
advantageous.
In
silico
computational
ultrasound-responsive
DDS
typically
involves
a
framework
acoustic
interactions,
heat
transfer,
release
from
nanoparticles,
fluid
flow,
mass
transport,
pharmacodynamic
governing
equations.
Owing
the
rapid
development
tools,
different
multi-scale
problems
involved
tumors
become
possible.
present
study,
we
an
in-depth
review
advances
TUS-mediated
A
detailed
discussion
is
also
provided
on
applying
these
models
improve
clinical
translation
applications
This
article
categorized
under:
Nanotechnology
Approaches
Biology
>
Nanoscale
Systems
Therapeutic
Drug
Discovery
Nanomedicine
Oncologic
Disease.
