Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 178 - 178
Опубликована: Янв. 31, 2025
Lipid
nanoparticles
(LNPs)
are
versatile
delivery
systems
with
high
interest
because
they
allow
the
release
of
hydrophobic
and
hydrophilic
molecules,
such
as
essential
oils
(EOs)
plant
extracts.
This
review
covers
published
works
between
2019
2024
that
have
reported
use
EO-based
LNPs
antimicrobial
properties
applications
in
human
animal
health,
well
biopesticides.
In
healthcare
field,
reports
addressed
effect
encapsulating
EOs
lipid
nanosystems
antiviral,
antibacterial,
antiprotozoal
antifungal
activities.
care,
this
still
needs
to
be
more
deeply
explored
while
looking
for
sustainable
alternatives
against
different
types
parasites
affect
health.
Overall,
antibacterial
activities
carrying
described
synthetic
antibiotics.
field
agriculture,
studies
showed
these
approaches
control
phytopathogens
other
pests
food
production.
There
is
a
growing
demand
innovative
technologies.
However,
there
some
challenges
overcome
order
innovations
reach
market.
Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Янв. 23, 2023
Abstract
MicroRNAs
(miRNAs)
are
a
group
of
small
non-coding
RNAs
that
regulate
gene
expression
by
targeting
mRNA.
Moreover,
it
has
been
shown
miRNAs
changed
in
various
diseases,
such
as
cancers,
autoimmune
disease,
infectious
and
neurodegenerative
Diseases.
The
suppression
miRNA
function
can
be
easily
attained
utilizing
anti-miRNAs.
In
contrast,
an
enhancement
achieved
through
the
utilization
modified
mimetics.
discovery
appropriate
carriers
body
become
interesting
subject
for
investigators.
Exosomes
(EXOs)
therapeutic
efficiency
safety
transferring
different
cellular
biological
components
to
recipient
cell
have
attracted
significant
attention
their
capability
carriers.
Mesenchymal
stem
cells
(MSCs)
recognized
generate
wide
range
EXOs
(MSC-EXOs),
showing
MSCs
may
effective
EXO
generation
clinically
measure
compared
other
origins.
MSC-EXOs
widely
investigated
because
immune
attributes,
tumor-homing
flexible
characteristics.
this
article,
we
summarized
features
MSC-EXOs,
including
production,
purification,
loading
methods
modification
targeted
delivery
diseases.
Graphical
abstract
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 21, 2023
Abstract
The
gradual
deterioration
of
the
supporting
periodontal
tissues
caused
by
periodontitis,
a
chronic
multifactorial
inflammatory
disease,
is
thought
to
be
triggered
colonization
dysbiotic
plaque
biofilms
in
vulnerable
host.
One
most
prevalent
dental
conditions
world,
periodontitis
now
leading
factor
adult
tooth
loss.
When
does
develop,
it
treated
scraping
mineralized
deposits
and
biofilm
off
surfaces.
Numerous
studies
have
shown
that
non-surgical
treatment
significantly
improves
clinical
microbiological
indices
individuals
with
periodontitis.
Although
parameters
improved,
certain
bacterial
reservoirs
often
persist
on
root
surfaces
even
after
standard
therapy.
Periodontitis
has
been
local
or
systemic
antibiotics
as
well
scaling
planning.
Since
there
aren't
many
brand-new
market,
several
researchers
are
currently
concentrating
creating
alternate
methods
combating
germs.
There
delay
study
subject
nanoparticle
(NP)
toxicity,
which
especially
concerned
mechanisms
action,
while
area
nanomedicine
develops.
promising
them
metal
NPs
since
they
potent
antibacterial
action.
Metal
may
employed
efficient
growth
inhibitors
variety
bacteria,
making
useful
for
In
this
way,
new
contributed
development
anti-inflammatory
platforms
current
therapeutic
effects
metallic
summarized
study.
This
data
might
used
develop
NP-based
alternatives
infections.
Graphical
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 5, 2024
Abstract
Periodontitis,
one
of
the
most
prevalent
dental
diseases,
causes
loss
bone
and
gum
tissue
that
hold
teeth
in
place.
Several
bacteria,
commonly
present
clinically
healthy
oral
cavities,
may
induce
perpetuate
periodontitis
when
their
concentration
rises
gingival
sulcus.
Antibacterial
effect
against
various
Gram-negative
Gram-positive
including
pathogenic
drug-resistant
ones,
has
been
shown
for
several
distinct
transient
metal
oxide
NPs.
Therefore,
NPs
be
used
biomedicine
to
treat
periodontal
problems
nanotechnology
inhibit
development
microorganisms.
Instead
using
harmful
chemicals
or
energy-intensive
machinery,
biosynthesis
nanoparticles
(NPs)
suggested.
To
produce
NPs,
ideal
technique
is
“Green”
synthesis
because
its
low
toxicity
safety
human
health
environment.
Gold
(AuNPs)
appear
less
toxic
mammalian
cells
than
other
nanometals
antibacterial
activity
not
dependent
on
reactive
oxygen
species
(ROS).
AgNPs
also
possess
chemical
stability,
catalytic
activity,
superior
electrical
thermal
conductivity,
name
a
few
advantageous
characteristics.
It
was
observed
zinc
(ZnO)
copper
(Cu)
exhibited
discernible
inhibitory
effects
gram-positive
gram-negative
bacterial
strains,
respectively.
ZnO
demonstrated
bactericidal
microorganisms
responsible
periodontitis.
Medications
containing
magnetic
are
highly
effective
multidrug-resistant
fungal
infections.
The
titanium
dioxide
(TiO
2
)
implicated
elevating
salivary
peroxidase
individuals
diagnosed
with
chronic
Furthermore,
specific
metallic
have
potential
enhance
antimicrobial
efficacy
treatments
combined.
these
as
well
only
some
metals
oxides
synthesized
environmentally
friendly
ways
therapeutic
benefits
Graphical
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 25, 2024
Abstract
Several
studies
suggest
that
oral
pathogenic
biofilms
cause
persistent
infections.
Among
these
is
periodontitis,
a
prevalent
condition
brought
on
by
plaque
biofilm.
It
can
even
result
in
tooth
loss.
Furthermore,
the
accumulation
of
germs
around
dental
implant
may
lead
to
peri-implantitis,
which
damages
surrounding
bone
and
gum
tissue.
bacterial
biofilm
contamination
causes
soft
tissue
irritation
adjacent
resorption,
severely
compromising
health.
On
decontaminated
surfaces,
however,
re-osseointegration
cannot
be
induced
standard
removal
techniques
such
as
mechanical
cleaning
antiseptic
treatment.
A
family
nanoparticles
known
nanozymes
(NZs)
comprise
highly
catalytically
active
multivalent
metal
components.
The
most
often
employed
NZs
with
antibacterial
activity
are
those
have
peroxidase
(POD)
activity,
among
other
types
NZs.
Since
less
expensive,
more
easily
produced,
stable
than
natural
enzymes,
they
hold
great
promise
for
use
various
applications,
including
treating
microbial
significantly
contributed
studying
success
rates
periodontal
health
maintenance
periodontics
implantology.
An
extensive
analysis
research
their
applications
managing
conditions,
caries,
pulp
disorders,
ulcers,
infections
mouth.
To
combat
bacteria,
this
review
concentrates
imitate
enzymes
implantology
periodontology.
With
view
future,
there
several
ways
might
used
treat
disorders
antibacterially.
Graphical
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 9, 2024
Abstract
One
of
the
most
effective
strategies
to
fight
viruses
and
handle
health
diseases
is
vaccination.
Recent
studies
current
applications
are
moving
on
antigen,
DNA
RNA-based
vaccines
overcome
limitations
related
conventional
vaccination
strategies,
such
as
low
safety,
necessity
multiple
injection,
side
effects.
However,
due
instability
pristine
RNA
molecules,
use
nanocarriers
required.
Among
different
proposed
for
vaccinal
applications,
three
types
nanovesicles
were
selected
analysed
in
this
review:
liposomes,
transfersomes
niosomes.
PubMed,
Scopus
Google
Scholar
databases
used
searching
recent
papers
frequently
innovative
methods
production
these
nanovesicles.
Weaknesses
(i.e.,
post-processing,
solvent
residue,
batch-mode
processes)
can
be
using
methods,
particular,
ones
assisted
by
supercritical
carbon
dioxide.
SuperSomes
process
emerged
a
promising
technique
solvent-free
nanovesicles,
since
it
easily
scaled-up,
works
continuous-mode,
does
not
require
further
post-processing
steps
obtain
desired
products.
As
result
literature
analysis,
dioxide
attracted
lot
interest
field.
despite
their
numerous
advantages,
processes
niosomes
with
aim
reaching
well-defined
technologies
suitable
industrial
mass
vaccines.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 223 - 223
Опубликована: Фев. 4, 2024
Niosomes
are
vesicular
nanocarriers,
biodegradable,
relatively
non-toxic,
stable,
and
inexpensive,
that
provide
an
alternative
for
lipid-solid
carriers
(e.g.,
liposomes).
may
resolve
issues
related
to
the
instability,
fast
degradation,
bioavailability,
insolubility
of
different
drugs
or
natural
compounds.
can
be
very
efficient
potential
systems
specific
delivery
anticancer,
antioxidant,
anti-inflammatory,
antimicrobial,
antibacterial
molecules.
This
review
aims
present
overview
their
composition,
most
common
formulation
techniques,
as
well
recent
utilizations
in
cancer
therapy.
Journal of Biological Engineering,
Год журнала:
2024,
Номер
18(1)
Опубликована: Апрель 18, 2024
Periodontitis,
a
chronic
inflammatory
condition
caused
by
bacteria,
often
causes
gradual
destruction
of
the
components
that
support
teeth,
such
as
alveolar
bone,
cementum,
periodontal
ligament,
and
gingiva.
This
ultimately
results
in
teeth
becoming
loose
eventually
falling
out.
Timely
identification
has
crucial
role
preventing
controlling
its
progression.
Clinical
measures
are
used
to
diagnose
periodontitis.
However,
now,
there
is
hunt
for
alternative
diagnostic
monitoring
methods
due
progress
technology.
Various
biomarkers
have
been
assessed
using
multiple
bodily
fluids
sample
sources.
Furthermore,
conventional
categorization
factors
do
not
provide
significant
insights
into
present
disease
activity,
severity
amount
tissue
damage,
future
development,
responsiveness
treatment.
In
recent
times,
growing
utilization
nanoparticle
(NP)-based
detection
strategies
create
quick
efficient
assays.
Every
single
one
these
platforms
leverages
distinct
characteristics
NPs
identify
Plasmonic
include
metal
NPs,
quantum
dots
(QDs),
carbon
base
nanozymes,
exceptionally
potent
light
absorbers
scatterers.
These
find
application
labeling,
surface-enhanced
spectroscopy,
color-changing
sensors.
Fluorescent
function
photostable
sensitive
instruments
capable
labeling
various
biological
targets.
article
presents
comprehensive
summary
latest
developments
effective
detect
Abstract
Proteins,
RNA,
DNA,
lipids,
and
carbohydrates
are
only
some
of
the
molecular
components
found
in
exosomes
released
by
tumor
cells.
They
play
an
essential
role
healthy
diseased
cells
as
messengers
short-
long-distance
intercellular
communication.
However,
since
every
kind
cell
may
be
blood
other
bodily
fluids,
they
one
day
serve
biomarkers
for
a
wide
range
disorders.
In
many
pathological
conditions,
including
cancer,
inflammation,
infection,
role.
It
has
been
shown
that
biogenesis
is
analogous
to
viruses
exosomal
cargo
plays
propagation,
dissemination,
infection
several
viruses.
Bidirectional
modulation
immune
response
achieved
ability
associated
with
facilitate
immunological
escape
stimulate
body's
antiviral
response.
Recently,
have
received
lot
interest
due
their
potential
therapeutic
use
viral
infections
such
human
immunodeficiency
virus
(HIV),
Hepatitis
B
(HBV),
C
(HCV),
Epstein–Barr
(EBV),
SARS-CoV-2.
This
article
discusses
purification
procedures
detection
techniques
examines
research
on
biomarker
infection.
Graphical
abstract
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Окт. 8, 2022
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
led
to
COVID-19
and
has
become
a
pandemic
worldwide
with
mortality
of
millions.
Nanotechnology
can
be
used
deliver
antiviral
medicines
or
other
types
viral
reproduction-inhibiting
medications.
At
various
steps
infection,
nanotechnology
could
suggest
practical
solutions
for
usage
in
the
fight
against
infection.
Nanotechnology-based
approaches
help
SARS-CoV-2
Nanoparticles
play
an
essential
role
progressing
treatment
vaccine
production
efficacy
safety.
Nanocarriers
have
increased
speed
development
efficiency
vaccines.
As
result,
investigation
into
nanoparticles
as
nano-delivery
systems
nanotherapeutics
new
effective
methods
are
inhibiting
In
this
article,
we
compare
attributes
several
evaluate
their
capability
create
novel
vaccines
different
diseases,
especially
disease.
Graphical
