The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 23, 2023

Abstract MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression by targeting mRNA. Moreover, it has been shown miRNAs changed in various diseases, such as cancers, autoimmune disease, infectious and neurodegenerative Diseases. The suppression miRNA function can be easily attained utilizing anti-miRNAs. In contrast, an enhancement achieved through the utilization modified mimetics. discovery appropriate carriers body become interesting subject for investigators. Exosomes (EXOs) therapeutic efficiency safety transferring different cellular biological components to recipient cell have attracted significant attention their capability carriers. Mesenchymal stem cells (MSCs) recognized generate wide range EXOs (MSC-EXOs), showing MSCs may effective EXO generation clinically measure compared other origins. MSC-EXOs widely investigated because immune attributes, tumor-homing flexible characteristics. this article, we summarized features MSC-EXOs, including production, purification, loading methods modification targeted delivery diseases. Graphical abstract

Language: Английский

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Recent advances in metal nanoparticles to treat periodontitis

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 21, 2023

Abstract The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered colonization dysbiotic plaque biofilms in vulnerable host. One most prevalent dental conditions world, periodontitis now leading factor adult tooth loss. When does develop, it treated scraping mineralized deposits and biofilm off surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical microbiological indices individuals with periodontitis. Although parameters improved, certain bacterial reservoirs often persist on root surfaces even after standard therapy. Periodontitis has been local or systemic antibiotics as well scaling planning. Since there aren't many brand-new market, several researchers are currently concentrating creating alternate methods combating germs. There delay study subject nanoparticle (NP) toxicity, which especially concerned mechanisms action, while area nanomedicine develops. promising them metal NPs since they potent antibacterial action. Metal may employed efficient growth inhibitors variety bacteria, making useful for In this way, new contributed development anti-inflammatory platforms current therapeutic effects metallic summarized study. This data might used develop NP-based alternatives infections. Graphical

Language: Английский

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Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 5, 2024

Abstract Periodontitis, one of the most prevalent dental diseases, causes loss bone and gum tissue that hold teeth in place. Several bacteria, commonly present clinically healthy oral cavities, may induce perpetuate periodontitis when their concentration rises gingival sulcus. Antibacterial effect against various Gram-negative Gram-positive including pathogenic drug-resistant ones, has been shown for several distinct transient metal oxide NPs. Therefore, NPs be used biomedicine to treat periodontal problems nanotechnology inhibit development microorganisms. Instead using harmful chemicals or energy-intensive machinery, biosynthesis nanoparticles (NPs) suggested. To produce NPs, ideal technique is “Green” synthesis because its low toxicity safety human health environment. Gold (AuNPs) appear less toxic mammalian cells than other nanometals antibacterial activity not dependent on reactive oxygen species (ROS). AgNPs also possess chemical stability, catalytic activity, superior electrical thermal conductivity, name a few advantageous characteristics. It was observed zinc (ZnO) copper (Cu) exhibited discernible inhibitory effects gram-positive gram-negative bacterial strains, respectively. ZnO demonstrated bactericidal microorganisms responsible periodontitis. Medications containing magnetic are highly effective multidrug-resistant fungal infections. The titanium dioxide (TiO 2 ) implicated elevating salivary peroxidase individuals diagnosed with chronic Furthermore, specific metallic have potential enhance antimicrobial efficacy treatments combined. these as well only some metals oxides synthesized environmentally friendly ways therapeutic benefits Graphical

Language: Английский

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Progress and prospects on vaccine development against monkeypox infection

Microbial Pathogenesis, Journal Year: 2023, Volume and Issue: 180, P. 106156 - 106156

Published: May 17, 2023

Language: Английский

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The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 25, 2024

Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical

Language: Английский

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Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 223 - 223

Published: Feb. 4, 2024

Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). may resolve issues related to the instability, fast degradation, bioavailability, insolubility of different drugs or natural compounds. can be very efficient potential systems specific delivery anticancer, antioxidant, anti-inflammatory, antimicrobial, antibacterial molecules. This review aims present overview their composition, most common formulation techniques, as well recent utilizations in cancer therapy.

Language: Английский

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Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 9, 2024

Abstract One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies current applications are moving on antigen, DNA RNA-based vaccines overcome limitations related conventional vaccination strategies, such as low safety, necessity multiple injection, side effects. However, due instability pristine RNA molecules, use nanocarriers required. Among different proposed for vaccinal applications, three types nanovesicles were selected analysed in this review: liposomes, transfersomes niosomes. PubMed, Scopus Google Scholar databases used searching recent papers frequently innovative methods production these nanovesicles. Weaknesses (i.e., post-processing, solvent residue, batch-mode processes) can be using methods, particular, ones assisted by supercritical carbon dioxide. SuperSomes process emerged a promising technique solvent-free nanovesicles, since it easily scaled-up, works continuous-mode, does not require further post-processing steps obtain desired products. As result literature analysis, dioxide attracted lot interest field. despite their numerous advantages, processes niosomes with aim reaching well-defined technologies suitable industrial mass vaccines.

Language: Английский

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Recent advances in nanomaterial-based biosensor for periodontitis detection

Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)

Published: April 18, 2024

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose eventually falling out. Timely identification has crucial role preventing controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is hunt for alternative diagnostic monitoring methods due progress technology. Various biomarkers have been assessed using multiple bodily fluids sample sources. Furthermore, conventional categorization factors do not provide significant insights into present disease activity, severity amount tissue damage, future development, responsiveness treatment. In recent times, growing utilization nanoparticle (NP)-based detection strategies create quick efficient assays. Every single one these platforms leverages distinct characteristics NPs identify Plasmonic include metal NPs, quantum dots (QDs), carbon base nanozymes, exceptionally potent light absorbers scatterers. These find application labeling, surface-enhanced spectroscopy, color-changing sensors. Fluorescent function photostable sensitive instruments capable labeling various biological targets. article presents comprehensive summary latest developments effective detect

Language: Английский

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A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 30, 2024

Abstract Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an essential role healthy diseased cells as messengers short- long-distance intercellular communication. However, since every kind cell may be blood other bodily fluids, they one day serve biomarkers for a wide range disorders. In many pathological conditions, including cancer, inflammation, infection, role. It has been shown that biogenesis is analogous to viruses exosomal cargo plays propagation, dissemination, infection several viruses. Bidirectional modulation immune response achieved ability associated with facilitate immunological escape stimulate body's antiviral response. Recently, have received lot interest due their potential therapeutic use viral infections such human immunodeficiency virus (HIV), Hepatitis B (HBV), C (HCV), Epstein–Barr (EBV), SARS-CoV-2. This article discusses purification procedures detection techniques examines research on biomarker infection. Graphical abstract

Language: Английский

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The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1181 - 1181

Published: March 6, 2025

Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.

Language: Английский

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