Journal of Controlled Release,
Год журнала:
2023,
Номер
362, С. 342 - 355
Опубликована: Сен. 5, 2023
Chronic
retinal
diseases,
such
as
age-related
macular
degeneration
(AMD),
are
a
major
cause
of
global
visual
impairment.
However,
current
treatment
methods
involving
repetitive
intravitreal
injections
pose
financial
and
health
burdens
for
patients.
The
development
controlled
drug
release
systems,
particularly
biological
drugs,
is
still
an
unmet
need
in
prolonging
within
the
vitreous
chamber.
To
address
this,
green
supercritical
carbon
dioxide
(scCO2)
foaming
technology
was
employed
to
manufacture
porous
poly(lactic-co-glycolic
acid)
(PLGA)-based
implants
loaded
with
dexamethasone.
desired
implant
dimensions
were
achieved
through
3D
printing
customised
moulds.
By
varying
depressurisation
rates
during
process,
different
porosities
dexamethasone
successfully
obtained.
These
demonstrated
up
four
months,
surpassing
performance
previously
developed
implants.
In
view
positive
results
obtained,
pilot
study
conducted
using
monoclonal
antibody
bevacizumab
explore
feasibility
this
preparing
intraocular
biologic
molecules.
Overall,
presents
greener
more
sustainable
alternative
conventional
manufacturing
techniques,
suited
drugs
that
susceptible
degradation
under
harsh
conditions.
Journal of Physics D Applied Physics,
Год журнала:
2023,
Номер
56(28), С. 285002 - 285002
Опубликована: Апрель 14, 2023
Abstract
Three-dimensional
(3D)
printing
technology
has
emerged
as
a
promising
tool
for
meticulously
fabricated
scaffolds
with
high
precision
and
accuracy,
resulting
in
intricately
detailed
biomimetic
3D
structures.
Producing
magnetic
the
aid
of
additive
processes,
known
printing,
reveals
multitude
state-of-the-art
areas
application
such
tissue
engineering,
bone
repair
regeneration,
drug
delivery
hyperthermia.
A
crucial
first
step
is
development
innovative
polymeric
composite
materials.
The
current
work
presents
fabrication
protocol
printed
polymer-bonded
magnets
using
Fused
Deposition
Modeling
method.
Polymer-bonded
are
defined
composites
permanent-magnet
powder
embedded
polymer
binder
matrix.
By
low-cost
mixing
extruder,
four
(4)
different
filament
types
1.75
mm
were
commercial
magnetite
nanoparticles
mixed
pure
polylactic
acid
(PLA)
ferromagnetic
PLA
(Iron
particles
included)
filaments.
mixture
basic
filaments
was
compounded
(NPs),
extruded
to
fabricate
filament,
which
subsequently
characterized
structurally
magnetically
before
process.
Magnetic
finally
concentration
magnetite.
Our
results
demonstrate
that
heating
efficiency
(expressed
W
g
−1
)
(ranging
from
2
5.5
at
field
intensity
30
mT
frequency
365
kHz)
can
be
tuned
by
choosing
either
or
non-magnetic
an
amount
NPs
concentrations
10
20
wt%.
opens
up
new
perspectives
future
research,
complex
structures
suitable
custom-made
adjusting
construction
aimed
improving
accuracy
hyperthermia
treatment.
ACS Applied Engineering Materials,
Год журнала:
2023,
Номер
1(4), С. 1142 - 1163
Опубликована: Март 7, 2023
Eyeglasses
are
typical
correctors
for
refractive
error
eye
disorders.
They
commonly
placed
on
frames
expected
to
be
stylish
and
durable.
Currently,
the
consumer
demand
sustainable
eco-friendly
is
gaining
interest,
especially
since
conventional
frame
manufacturing
methods
follow
a
subtraction
of
large
blocks
wasted
scrap
material.
Additive
(AM)
promises
better
economic
feasibility
due
reduced
tooling,
storage,
material
costs,
as
well
enhanced
mechanical
properties,
by
inducing
nanomaterials
composites.
Moreover,
synergism
between
AM
digital
design
has
led
rising
interest
in
smart
or
electronic
eyeglass
frames.
This
systematic
review
assesses
commercial
that
use
standard
materials
with
long-lasting
resistance,
durability,
comfort,
versatility
various
such
metals
polymers.
It
also
explores
aspects
these
eyeglasses
their
correlation
utilization
artificial
intelligence
trained
computer-aided
software.
Beyond
appealing
technology,
design,
which
sensors
chips
embedded,
included.
Furthermore,
this
comprises
applications
3D
printing
including
biomedical
applications.
Other
reviewed
topics
include
side
effects,
health
risks,
shortcomings
techniques
materials,
void
formation
inside
matrix
propagates
fatigue
shrinkage
density
change
during
solidification.
Biomimetics,
Год журнала:
2024,
Номер
9(3), С. 145 - 145
Опубликована: Фев. 27, 2024
In
the
forefront
of
ophthalmic
innovation,
biomimetic
3D
printing
and
bioprinting
technologies
are
redefining
patient-specific
therapeutic
strategies.
This
critical
review
systematically
evaluates
their
application
spectrum,
spanning
oculoplastic
reconstruction,
retinal
tissue
engineering,
corneal
transplantation,
targeted
glaucoma
treatments.
It
highlights
intricacies
these
technologies,
including
fundamental
principles,
advanced
materials,
bioinks
that
facilitate
replication
ocular
architecture.
The
synthesis
primary
studies
from
2014
to
2023
provides
a
rigorous
analysis
evolution
current
clinical
implications.
is
unique
in
its
holistic
approach,
juxtaposing
scientific
underpinnings
with
realities,
thereby
delineating
advantages
over
conventional
modalities,
identifying
translational
barriers.
elucidates
persistent
knowledge
deficits
outlines
future
research
directions.
ultimately
accentuates
imperative
for
multidisciplinary
collaboration
enhance
integration
biotechnologies,
culminating
paradigm
shift
towards
individualized
care.
Perspectives of the ASHA Special Interest Groups,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Янв. 7, 2025
Purpose:
This
study
examined
the
learning
experiences
of
speech-language
pathology
students
after
creating
three-dimensional
(3D)
anatomical
models
as
part
an
undergraduate
Anatomy
and
Physiology
course.
Method:
A
total
44
used
3D
software
programs
to
design
components
(e.g.,
larynx,
brainstem,
brain
cortex,
ear,
or
mouth)
relevant
pathology.
Subsequently,
40
(90.9%)
completed
a
questionnaire
regarding
their
experiences.
Results:
The
data
revealed
that
most
(60%)
reported
no
prior
experience
with
designs.
However,
subsequent
analyses
indicated
greater
proportion
perceived
more
positive
about
anatomy
(82.5%),
physiology
(72.5%),
disorders
(72.5%)
related
model
compared
those
who
did
not
perceive
experience.
Additionally,
preferred
kinesthetic
style
expressed
higher
satisfaction
(
p
=
.02)
than
auditory
style.
Conclusion:
findings
suggest
integrating
designs
into
curriculum
could
provide
concepts
disorders.
Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
Current
limitations
in
treating
retinal
diseases
like
age‐related
macular
degeneration
(AMD)
and
diabetic
retinopathy
(DR)
are
due
to
the
short
ocular
residence
time
of
biologics
difficulty
precise
drug
delivery.
In
turn,
frequent
injections
required,
hindering
patient
compliance,
increasing
healthcare
costs.
This
study
explores
development
a
collagen‐based
implant
using
3D
bioprinting
platform
address
these
challenges.
The
offers
dual
functionalities:
i)
sustained
localized
delivery
situ
polymerization
collagen
(IPC)
act
as
reservoirs
for
prolonged
release
target
tissue
ii)
scaffold
stability
through
incorporation
methacrylated
hyaluronic
acid
(HAMA)
enhance
mechanical
properties
IPC
implant,
making
it
suitable
printing
targeted
systems.
data
demonstrates
that
IPC‐HAMA
implants
exhibit
slow
over
80
days.
Additionally,
enables
targeting
volumetric
control
within
simulated
vitreous
humor,
overcoming
challenges
associated
with
traditional
injection
methods.
innovative
approach
has
potential
revolutionize
therapy
diseases.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 219 - 219
Опубликована: Фев. 8, 2025
Purpose:
Dry
eye
disease
is
highly
prevalent,
and
the
most
common
treatment,
lubricating
drops,
only
remains
effective
for
a
very
short
period
of
time.
This
project
aims
to
3D
print
proof-of-concept,
custom-fit,
polyvinyl
alcohol
(PVA)-eluting
contact
lens
(CL)
treatment
dry
disease.
PVA
commonly
used
viscosity
enhancer
in
with
capability
reducing
symptoms
by
stabilizing
tear
film
evaporation.
The
protective
effects
could
be
attributed
its
water-retaining
ability,
which
provides
moisturization
prevents
loss
water.
Method:
In
this
work,
low-cost
stereolithography-based
printer
was
retrofitted
humidity
temperature
control
kit
PVA-loaded
custom-fit
CL.
To
evaluate
quality
3D-printed
CL,
circularity
shape
fidelity
printing.
release
from
these
lenses
assessed,
along
role
acting
as
enhancer.
effect
further
analyzed
(desiccation
stress)
cell
model.
Results:
evaluation
CL
displayed
excellent
circularity.
diameter,
sagittal
depth,
base
curve
were
measured
14.27
±
0.06
mm,
3.77
0.16
6.4
0.24
respectively.
curves
showed
that
approximately
1300
µg
released
over
study
duration
24
h.
Conclusions:
Overall,
work
demonstrates
PVA-eluting
promising
candidate
eye.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Microneedles
(MNs)
have
been
used
as
active
drug
delivery
carriers
by
precisely
delivering
drugs
to
the
targeted
site
along
with
minimal
tissue
destruction.
Earlier,
MNs
were
for
of
transdermal
site;
now
they
are
solid
tumor
site,
mucosal,
ophthalmic,
and
other
organ
site-specific
delivery.
considered
a
boon
trans-barrier
because
routes,
such
systemic
parenteral,
face
challenges
limiting
optimum
amount
reaching
skin
or
barrier-containing
organs.
Hence,
MN-mediated
enhances
permeation
improves
brain
ciliary
nasal
clearance
crossing
barrier.
The
current
book
chapter
mainly
focuses
on
recent
advancements
in
area
MN-based
into
various
parts
body,
their
theragnostic
applications,
organs
containing
barriers,
encounters
has
discussed.
Also,
comprehensive
overview
MN
types,
fabrication
polymers,
mechanisms
release,
effectiveness,
advantages
over
conventional
systems
summarized.
Journal of Pharmacy and Pharmacology,
Год журнала:
2023,
Номер
75(2), С. 276 - 286
Опубликована: Янв. 8, 2023
To
develop
a
sustained
release
5-fluorouracil
(5-FU)
implant
by
three-dimensional
(3D)
printing
to
effectively
prevent
conjunctival
fibrosis
after
glaucoma
surgery.
