American Journal of Undergraduate Research,
Год журнала:
2023,
Номер
20(3), С. 99 - 106
Опубликована: Дек. 31, 2023
Titanium
is
a
component
of
many
implants
and
orthopedic
instruments,
such
as
screws
rods;
however,
this
other
materials
may
serve
nidus
for
bacterial
biofilm
attachment.
Chitosan
biopolymer
with
advantages
surface
modifier,
silver
ions
have
broad-spectrum
antimicrobial
properties.
For
study,
chitosan
bound
to
through
novel,
patented
process.
The
purpose
research
characterize
silane-linked
chitosan-silver
coatings
titanium,
including
comparing
efficacy.
In
titanium
coupons
reduced
Staphylococcus
aureus
(S.
aureus)
viability
by
98%
(planktonic)
99.5%
(biofilm)
while
supporting
Saos-2
osteoblast
cells
at
levels
75%
compared
control
uncoated
titanium.
Due
the
observation
retaining
reducing
viability,
could
be
useful
reduce
post-operative
infection
well
support
healing
KEYWORDS:
Titanium;
aureus;
Silver;
Chitosan;
Silane;
Osteoblast;
Antimicrobial;
Coating
Abstract
Owing
to
their
mechanical
resilience
and
non‐toxicity,
titanium
implants
are
widely
applied
as
the
major
treatment
modality
for
clinical
intervention
against
bone
fractures.
However,
intrinsic
bioinertness
of
Ti
its
alloys
often
impedes
effective
osseointegration
implants,
leading
severe
adverse
complications
including
implant
loosening,
detachment,
secondary
damage.
Consequently,
new
engineering
strategies
urgently
needed
improve
after
implantation.
Remarkably,
metalorganic
frameworks
(MOFs)
a
class
novel
synthetic
material
consisting
coordinated
metal
species
organic
ligands,
which
have
demonstrated
plethora
favorable
properties
modulating
interfacial
implants.
This
review
comprehensively
summarizes
recent
progress
in
development
MOF‐coated
highlights
potential
utility
bio‐implant
interface
osseointegration,
discussions
outlined
according
physical
traits,
chemical
composition,
drug
delivery
capacity.
A
perspective
is
also
provided
this
regarding
current
limitations
future
opportunities
orthopedic
applications.
The
insights
may
facilitate
rational
design
more
advanced
with
enhanced
therapeutic
performance
safety.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 15, 2024
Metal-organic
frameworks
(MOFs)
have
been
extensively
considered
as
one
of
the
most
promising
types
porous
and
crystalline
organic-inorganic
materials,
thanks
to
their
large
specific
surface
area,
high
porosity,
tailorable
structures
compositions,
diverse
functionalities,
well-controlled
pore/size
distribution.
However,
developed
MOFs
are
in
powder
forms,
which
still
some
technical
challenges,
including
abrasion,
dustiness,
low
packing
densities,
clogging,
mass/heat
transfer
limitation,
environmental
pollution,
mechanical
instability
during
process,
that
restrict
applicability
industrial
applications.
Therefore,
recent
years,
attention
has
focused
on
techniques
convert
MOF
powders
into
macroscopic
materials
like
beads,
membranes,
monoliths,
gel/sponges,
nanofibers
overcome
these
challenges.Three-dimensional
(3D)
printing
technology
achieved
much
interest
because
it
can
produce
many
high-resolution
with
complex
shapes
geometries
from
digital
models.
this
review
summarizes
combination
different
3D
strategies
MOF-based
for
fabricating
3D-printed
monoliths
applications,
emphasizing
water
treatment
gas
adsorption/separation
Herein,
various
fabrication
such
direct
ink
writing,
seed-assisted
in-situ
growth,
coordination
replication
solid
precursors,
matrix
incorporation,
selective
laser
sintering,
light
processing,
described
relevant
examples.
Finally,
future
directions
challenges
also
presented
better
plan
trajectories
shaping
improved
control
over
structure,
composition,
textural
properties
monoliths.
Biomaterials Science,
Год журнала:
2024,
Номер
12(23), С. 5912 - 5932
Опубликована: Янв. 1, 2024
With
the
population
aging,
osteoporosis
(OP)
is
becoming
more
and
common,
seriously
affecting
patients'
quality
of
life
their
families,
how
to
prevent
treat
has
become
a
hot
topic.
However,
current
conventional
method
treating
OP
oral
anti-osteoporosis
medication,
which
drawbacks
such
as
first-pass
elimination
gastrointestinal
adverse
effects.
At
same
time,
can
lead
microbial
infections
need
promote
angiogenesis
for
bone
healing,
among
other
needs
that
often
cannot
be
met
with
treatments,
there
risk
resistance
antibiotics
infections.
Metal-organic
frameworks
(MOFs)
having
high
specific
surface
area,
porosity,
controlled
degradation,
variable
composition;
they
not
only
used
carrier
control
drug
release,
but
also
play
multiple
roles
in
treatment
by
releasing
metal
ions,
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100866 - 100866
Опубликована: Ноя. 26, 2023
The
significance
of
the
osteogenesis-angiogenesis
relationship
in
healing
process
bone
defects
has
been
increasingly
emphasized
recent
academic
research.
Surface
topography
plays
a
crucial
role
guiding
cellular
behaviors.
Metal-organic
framework
(MOF)
is
an
innovative
biomaterial
with
nanoscale
structural
and
topological
features,
enabling
modulation
scaffold
physicochemical
properties.
This
study
involved
loading
varying
quantities
UiO-66
nanocrystals
onto
alkali-heat
treated
3D-printed
titanium
scaffolds,
resulting
formation
hierarchical
micro/nano
named
UiO-66/AHTs.
properties
these
scaffolds
were
subsequently
characterized.
Furthermore,
impact
on
osteogenic
potential
BMSCs,
angiogenic
HUVECs,
their
intercellular
communication
investigated.
findings
this
indicated
that
1/2UiO-66/AHT
outperformed
other
groups
terms
induction,
as
well
promoting
crosstalk
by
enhancing
paracrine
effects.
These
results
suggest
promising
biomimetic
design
facilitates
coupling
osteogenesis
angiogenesis.
