Highly Biocompatible Lamellar Liquid Crystals Based on Hempseed or Flaxseed Oil with Incorporated Betamethasone Dipropionate: A Bioinspired Multi-Target Dermal Drug Delivery System for Atopic Dermatitis Treatment

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 13687 - 13715

Опубликована: Дек. 1, 2024

Purpose: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease that severely impairs patient's life quality and represents significant therapeutic challenge due to its pathophysiology arising from barrier dysfunction.Topical corticosteroids, mainstay treatment for mild moderate AD, are usually formulated into conventional dosage forms impeded by low drug permeation, resulting in high doses with consequent adverse effects, also lack properties would strengthen barrier.Herein, we aimed develop biomimetic lamellar lyotropic liquid crystals (LLCs), offering a novel alternative AD treatment.Methods: In screening studies, pseudoternary phase diagrams alongside polarized light microscopy (PLM) viscosity measurements were utilized.Next, selected LCCs underwent comprehensive characterization via PLM, small-angle X-ray scattering, differential scanning calorimetry, rheological analysis.Lastly, their performance was evaluated compared commercially available reference medicine chemical stability study, vitro permeation testing, safety assessment using cell proliferation assay, inverted microscopy, Raman mapping of keratinocytes, besides gap closure assay performed live-cell imaging.Results: Formulation (L/T)Ho30, containing highest amount lecithin/Tween 80 mixture (21%) hempseed oil (28%), demonstrated microstructure hydration potential favourable features administration.Moreover, comparison medicine, it stood out providing suitable BD (betamethasone dipropionate) stability, improved 3-fold excellent biocompatibility over 85% at all tested concentrations, ensuring keratinocytes' integrity, as well promoting healing observed after 36 hours.Conclusion: Unique multi-target delivery strategy depicted newly developed bioinspired structurally resembling stratum corneum intercellular lipids, incorporated drug, composed multifunctional components synergistically barrier, presented here shows promising approach treatment.

Язык: Английский

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Injectable long-acting formulations (ILAFs) and manufacturing techniques

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(6), С. 881 - 904

Опубликована: Июнь 2, 2024

Most therapeutics delivered using short-acting formulations need repeated administration, which can harm patient compliance and raise failure risks related to inconsistent treatment. Injectable long-acting (ILAFs) are controlled/sustained-release fabricated deliver active pharmaceutical ingredients (APIs) extend their half-life over days months. Longer half-lives of ILAFs minimize the necessity for frequent doses, increase compliance, reduce risk side effects from intravenous (IV) infusions. Using ILAF technologies, immediate drug release also be controlled, thereby minimizing potential adverse due high initial blood concentrations.

Язык: Английский

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Nanostructure Formation in Glycerolipid Films during Enzymatic Hydrolysis: A GISAXS Study

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Responsive nanostructured films from food-grade lipids can be valuable for food, pharmaceutical, and biotechnological science. Lyotropic liquid crystalline structures that respond to enzymes in their environment can, instance, innovated as drug delivery platforms or biosensors. However, the structural changes such undergo during enzymatic reactions with lipase are not yet understood. This work demonstrates preparation of mesostructured lipid glycerol monooleate (GMO) triolein on silicon wafers digestion pancreatic using time-resolved synchrotron grazing incidence small-angle X-ray scattering (GISAXS). The film structure is compared corresponding GMO/triolein bulk phases excess water. Increasing ratio makes it possible modulate oil coatings inverse hexagonal bicontinuous cubic films. Pancreatic triggered swelling internal nanostructure eventually transformation inside film. Orientation reorientation relative wafer surface were observed digestion. findings contribute understanding self-assembly thin guide development enzyme-responsive functional modification various substrates.

Язык: Английский

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Phase behavior and biological activity of lyotropic liquid crystal systems doped with 1,2,3-triazole derivative

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126352 - 126352

Опубликована: Окт. 1, 2024

Язык: Английский

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Investigation of the relation between surfactant head group size and formation of different types of lyotropic structures in two surfactants/dye systems

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126589 - 126589

Опубликована: Ноя. 1, 2024

Язык: Английский

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