ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 70378 - 70391
Опубликована: Дек. 12, 2024
Transdermal
insulin
delivery
in
a
painless,
convenient,
and
on-demand
way
remains
long-standing
challenge.
A
variety
of
smart
microneedles
(MNs)
fabricated
by
glucose-responsive
phenylboronic
acid
hydrogels
have
been
previously
developed
to
provide
painless
autonomous
release
response
glucose
level
change.
However,
like
the
majority
MNs,
their
transdermal
efficiency
was
still
relatively
low
compared
that
with
subcutaneous
injection.
Herein,
we
report
an
iontophoresis
(ITP)-integrated
MNs
platform
enhanced
depth.
Carbon
nanotubes
(CNTs)
were
induced
boronate-containing
hydrogel
develop
semi-interpenetrating
network
stiffness
conductivity.
Remarkably,
ITP
not
only
facilitated
efficient
deeper
via
electroosmosis
electrophoresis
but
also
well-maintained
responsiveness.
This
ITP-combined
platform,
which
could
safe
way,
is
promising
achieve
persistent
glycemic
control.
Furthermore,
payloads
wide
size
range
achieved
this
thus
shed
light
on
development
deep
skin
penetration
minimally
invasive
way.
Abstract
Recent
strides
in
non‐invasive
drug
delivery
have
spurred
innovation
alternatives
to
traditional
needle
injections.
Transdermal
systems
(TDDs)
emerged
as
a
particularly
promising
avenue,
boasting
minimal
rejection
rates,
user‐friendly
administration,
and
enhanced
patient
adherence.
Beyond
pharmaceuticals,
TDDs
show
potential
skincare
cosmetics,
leveraging
their
ability
facilitate
localized
while
minimizing
systemic
exposure.
Nonetheless,
the
intricate
physicochemical
nature
of
skin
presents
formidable
obstacles,
prompting
intensive
exploration
overcome
these
barriers.
This
comprehensive
review
delves
into
landscape
methodologies,
critically
analyzing
respective
advantages,
limitations,
characterization
prospective
applications.
advancements
underscore
robust
efficacy
TDDs,
positioning
it
versatile
indispensable
modality
poised
for
widespread
integration
across
multifarious
fields.
For
highly
efficient
and
precise
drug
release,
transdermal
delivery
systems
(TDDS)
have
recently
evolved
through
the
combination
of
intelligent
material-based
structures
with
various
active
components.
These
strategies
are
an
effort
to
overcome
significant
difficulties
in
delivering
large
molecule
drugs
nanomaterials
due
physical
barrier
skin,
especially
stratum
corneum,
traditional
TDDS.
Interestingly,
multiscale
suction-driven
architectures
(SDAs)
inspired
by
bioinspired
suction
adhesion
mechanisms
provided
innovative
solutions
these
challenges.
employ
negative
pressure
enhance
nanoscale
skin-controllable
skin
adhesion,
temporarily
bypass
barrier,
facilitate
deep
penetration
therapeutic
agents,
thereby,
achieving
goals
increasing
efficiency
maximizing
user
convenience
as
a
minimal
invasive,
needle-free
platform.
This
review
provides
comprehensive
overview
patches
emphasizes
their
integration
multifunctional
materials
achieve
stable
controlled
release.
Next,
we
present
cost-effective
user-friendly
patch
devices
optimization
cupping
without
incorporation
additional
devices.
Furthermore,
that
optimize
need
for
Potential
SDAs
localized
systemic
challenging
complex
well
future
perspectives,
discussed,
along
directions
more
patient-centric
solutions.
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Апрель 2, 2025
To
establish
a
detailed
step-by-step
example
for
the
topical
development
of
generic
products.
Topical
semisolids
are
complex
products
requiring
extensive
research
bioequivalence
by
establishing
Q1/Q2/Q3.
The
process
establishes
Q1/Q2
selection
and
Q3
evaluation
innovator
proposed
formulation.
product
along
with
formulation
has
been
evaluated
physicochemical
properties.
Once
structure
is
matched
formulation,
invitro
release
in-vitro
permeation
study
have
conducted
to
move
forward
study.
Pharmacokinetic
pharmacodynamic
studies
were
employed
an
in
humans.
Selection
Q1
Q2
composition
through
literature
search
reverse
engineering.
test
reference
pharmaceutically
equivalent
characterization,
IVRT,
IVPT.
In
PK
study,
samples
compared
Cmax,
Tmax,
t1/2
found
bioequivalent.
PD
was
performed
pilot
pivotal
dose
duration
response
relationship
respectively
without
adverse
events.
A
crucial
exhibited
that
formulations
bioequivalent
90%
confidence
interval
results
84.67%∼101.09%.
Cutivate®
cream
0.05%,
Fluticasone
Propionate
0.05%
favorable
safety
profile.
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Iontophoresis
has
been
extensively
studied
for
topical
and
transdermal
drug
delivery
to
stimulate
the
absorption
of
molecules
that
would
hardly
pass
through
outermost
layer
skin
passively.
Recent
research
focused
on
its
combination
with
nanoparticle-based
systems
or
microneedles
expand
therapeutic
applications.
This
review
explores
fundamental
principles
iontophoresis,
focusing
key
factors
influencing
transport
mechanisms,
provides
a
discussion
field's
current
state.
A
comprehensive
analysis
articles
published
available
online
in
2024
was
conducted,
categorizing
studies
by
their
application
areas,
systems,
iontophoretic
conditions,
experimental
limitations.
The
findings
reveal
recent
focus
wound
healing
repair,
advancements
treating
inflammation,
pain,
cancer.
Market
translation
requires
standardized
protocols,
particularly
parameters
preclinical
models,
along
development
cost-effective
commercial
devices.
Additionally,
while
cutaneous
have
increasingly
benefited
from
machine
learning
approaches,
iontophoresis
remains
underexplored.
With
growing
interest
associating
Internet
Things,
such
an
integration,
if
combined
AI
tools,
could
offer
promising
opportunities
personalized,
real-time
treatments
modern
dermatology,
systems.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Abstract
Transdermal
healthcare
systems
have
gained
significant
attention
for
their
painless
and
convenient
drug
administration,
as
well
ability
to
detect
biomarkers
promptly.
However,
the
skin
barrier
limits
candidates
of
biomolecules
that
can
be
transported,
reliance
on
simple
diffusion
poses
a
bottleneck
personalized
diagnosis
treatment.
Consequently,
recent
advancements
in
transdermal
transport
technologies
evolved
toward
active
methods
based
external
energy
sources.
Multiple
combinations
these
also
shown
promise
increasing
therapeutic
effectiveness
diagnostic
accuracy
delivery
efficiency
is
maximized.
Furthermore,
wearable
platforms
are
being
developed
diverse
aspects
patient
convenience,
safety,
on‐demand
Herein,
comprehensive
overview
provided,
highlighting
combination‐based
diagnostics,
therapeutics,
theragnostics,
along
with
latest
trends
platform
advancements.
This
offers
insights
into
potential
applications
next‐generation
medical
devices
autonomous
healthcare.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 1163 - 1183
Опубликована: Фев. 1, 2025
Infantile
hemangiomas
(IHs)
are
a
kind
of
skin
soft
tissue
benign
tumors
in
infants,
with
high
incidence
rate
and
significant
harm.
Rapid
early
proliferation
can
cause
severe
cosmetic
deformities
organ
development
disorders.
Propranolol
Hydrochloride
(PRH),
non-selective
adrenergic
β-receptor
blocker,
has
become
the
first-line
treatment
for
IHs
due
to
its
good
efficacy
safety
compared
other
drugs.
To
further
improve
bioavailability
PRH,
deliver
it
more
safely
effectively
lesion
site,
enhance
patient
compliance,
researchers
continually
developing
new
PRH
formulations
IHs.
This
article
briefly
introduced
pathogenesis
therapeutic
mechanism
PRH.
It
also
provided
detailed
overview
various
developed
over
past
12
years
IHs,
including
improved
oral
formulations,
topical
creams,
gels,
liposomes/nanoparticles,
transdermal
patches,
microneedles,
targeted
injectable
formulations.
summarized
prospects
technical
challenges
these
aims
provide
comprehensive
review
recent
advances
propranolol
technologies
treating
offering
reference
research
application.
At
same
time,
is
hoped
that
be
efficiently
used
clinical
practice
future.
