Journal of Lipid Research, Год журнала: 2024, Номер unknown, С. 100729 - 100729
Опубликована: Дек. 1, 2024
Язык: Английский
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 272, С. 116508 - 116508
Опубликована: Май 15, 2024
Язык: Английский
Процитировано
15
Frontiers in Nanotechnology, Год журнала: 2024, Номер 6
Опубликована: Окт. 21, 2024
Nanoparticles are attractive therapeutic tools due to their distinctive characteristics, including more accurate drug delivery, improved bioavailability, and enhanced targeted therapy. This review offers a comprehensive analysis of the potentials cutting-edge nanoparticles as demonstrated in human clinical trials, based on empirical evidence. Through systematic searches major scientific databases, relevant studies published up March 2024 were included, focusing trials utilizing advanced for purposes. The discusses diverse applications oncology, infectious diseases, neurology, other medical fields. Additionally, it scrutinizes safety profiles, efficacy outcomes, challenges associated with nanoparticle-based therapies. findings underscore significant progress translating nanoparticle research into practice highlight potential these innovative platforms revolutionize treatments. contributes valuable insights growing field therapeutics, fostering deeper understanding implications practice.
Язык: Английский
Процитировано
13
Dyes and Pigments, Год журнала: 2024, Номер 229, С. 112262 - 112262
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
10
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 932 - 932
Опубликована: Июль 12, 2024
Cancer remains a significant global health challenge, with traditional therapies like surgery, chemotherapy, and radiation often accompanied by systemic toxicity damage to healthy tissues. Despite progress in treatment, these approaches have limitations such as non-specific targeting, toxicity, resistance development cancer cells. In recent years, nanotechnology has emerged revolutionary frontier therapy, offering potential solutions challenges. Nanoparticles, due their unique physical chemical properties, can carry therapeutic payloads, navigate biological barriers, selectively target Metal-based nanoparticles, particular, offer properties suitable for various applications. Recent advancements focused on the integration of metal-based nanoparticles enhance efficacy precision photodynamic therapy. Integrating into therapy represents paradigm shift, enabling strategies enhanced specificity reduced off-target effects. This review aims provide comprehensive understanding pivotal role We explore mechanisms, biocompatibility, applications highlighting challenges use, well combining nanoparticles/photodynamic other synergistic approach treatment.
Язык: Английский
Процитировано
7
Cancers, Год журнала: 2024, Номер 16(11), С. 2030 - 2030
Опубликована: Май 27, 2024
Immunotherapy is a rapidly advancing field of research in the treatment conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, inorganic NPs, discuss their detailed design intricacies, mechanisms, applications, current regulatory issues. This type nanomaterial targeting specific cells or tissues controlling release kinetics could push technological frontiers provide new innovative solutions immune-related disorders diseases without off-target effects. These materials enable interactions cells, thereby enhancing effectiveness checkpoint inhibitors, vaccines, adoptive cell therapies. Moreover, they allow fine-tuning responses while minimizing side At intersection nanotechnology immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy reshape disease management. By prioritizing safety, customization, compliance standards, these systems make significant contributions precision medicine, significantly impacting healthcare landscape.
Язык: Английский
Процитировано
5
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
An overview of cyanine dye-based phototherapy agents, including the design strategies, relationships between molecular structures and properties, as well applications in photodynamic therapy, photothermal multimodal combined therapy.
Язык: Английский
Процитировано
5
Autophagy, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Macropinocytosis is a nonselective form of endocytosis that allows cancer cells to largely take up the extracellular fluid and its contents, including nutrients, growth factors, etc. We first elaborate meticulously on process macropinocytosis. Only by thoroughly understanding this entire can we devise targeted strategies against it. then focus central role MTOR (mechanistic target rapamycin kinase) complex 1 (MTORC1) in regulating macropinocytosis, highlighting significance as key signaling hub where various pathways converge control nutrient uptake metabolic processes. The article covers comprehensive analysis literature molecular mechanisms governing initiation, maturation, recycling macropinosomes, with an emphasis how these processes are hijacked sustain their growth. Key discussions include potential therapeutic targeting such enhancing drug delivery via pathway, inhibiting macropinocytosis starve cells, blocking degradation inducing methuosis – cell death triggered excessive Targeting represents novel innovative approach could significantly advance treatment cancers rely pathway for survival. Through continuous research innovation, look forward developing more effective safer anti-cancer therapies will bring new hope patients.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The potential use of plasmonic photothermal therapy mediated by bipyramidal gold nanoparticles in ophthalmology has been described for the first time.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Methicillin-resistant Staphylococcus aureus (MRSA)-related bone defects pose significant clinical challenges due to treatment failures. Here, an injectable nanohybrid hydrogel (FND-ZHD) is developed that combines controlled low-temperature photothermal antibacterial therapy with enhanced regeneration. The uses Pluronic F-127 as the matrix, incorporating polydopamine-coated nano-hydroxyapatite and zinc oxide nanoparticles encapsulated polydopamine hyaluronic acid, forming a sophisticated nanostructured composite. Under near-infrared (NIR) irradiation, FND-ZHD exhibits efficient properties, enabling precise eliminate MRSA infections. process generates reactive oxygen species (ROS), contributing potent activity, while design allows self-elimination of excess ROS minimize cytotoxicity. Simultaneously, enhances regeneration by upregulating heat shock protein 70 (HSP70), promoting osteogenic differentiation accelerating repair. In vitro in vivo experiments demonstrate not only possesses strong efficacy against but also significantly improves healing infected defect models. This dual-function strategy leverages synergistic effects nanomaterials at nano- microscale, achieving simultaneous action work highlights potential nanotechnology-based multifunctional biomaterials addressing complex medical problems, paving way for advanced therapies orthopedic regenerative medicine.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Апрель 1, 2025
The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.
Язык: Английский
Процитировано
0