Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115478 - 115478
Опубликована: Ноя. 1, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125180 - 125180
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 6, 2025
Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.
Язык: Английский
Процитировано
1
Physical Sciences Reviews, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Abstract This review provides insight on how the application of core chemical engineering concepts helps with current challenges in dermal permeation research from a mathematical modelling perspective. The skin fundamentally behaves like diffusion reactor, where mass conservation featuring Fick’s flux can be applied to obtain differential equations that govern compound. Advanced phenomena systemic circulation or complex thermodynamics added mathematically into models complement equation. Depending objectives, reach these mechanistic continuum mechanics can: i) consider as homogeneous compartment, spatial dependency is overlooked, ii) include detailed spatio-temporally-discretised geometric descriptions features bricks-and-mortar layout stratum corneum. capabilities this powerful approach study advanced topics dermatological are discussed. These such role hair follicle shortcut bypass corneum, effect evaporation during multicomponent formulations, and facilitation by means external forces (i.e., electromagnetic fields mechanical action). chapter closes note towards future development Digital Twins, which gaining further importance late avoid animal experimentation research.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106836 - 106836
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124995 - 124995
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Medicines, Год журнала: 2025, Номер 12(1), С. 4 - 4
Опубликована: Фев. 7, 2025
Vaccination represents a critical preventive strategy in the current global healthcare system, serving as an indispensable intervention against diverse pathogenic threats. Although conventional immunization relies predominantly on hypodermic needle-based administration, this method carries substantial limitations, including needle-associated fear, bloodborne pathogen transmission risks, occupational injuries among workers, waste management issues, and dependence trained medical personnel. Microneedle technology has emerged innovative vaccine delivery offering convenient, effective, minimally invasive administration. These microscale needle devices facilitate targeted antigen to epidermal dermal tissues, where abundant populations of antigen-presenting cells, specifically Langerhans dendritic provide robust immunological responses. Multiple research groups have extensively investigated microneedle-based vaccination strategies. This transdermal technique offers several advantages, notably circumventing cold-chain requirements enabling self-administration. Numerous preclinical investigations clinical trials demonstrated safety profile, immunogenicity, patient acceptance microneedle-mediated across applications. comprehensive review examines fundamental aspects immunization, principles, transcutaneous strategies, delivery-including classifications, barriers. Furthermore, addresses technical considerations, such treatment efficacy, application methodologies, wear duration, dimensional optimization, manufacturing processes, regulatory frameworks, sustainability followed by analysis future perspective technology.
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 20, 2024
Plant-derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the potential plant-derived EVs emphasizes anti-inflammatory, antimicrobial, tumor-inhibitory effects. Here, we discussed advancements in isolation purification techniques, such as ultracentrifugation size-exclusion chromatography, which critical for maintaining functional integrity these nanovesicles. Next, investigated diverse administration routes carefully weighed respective advantages challenges related bioavailability patient compliance. Moreover, elucidated multifaceted mechanisms action EVs, including roles anti-inflammation, antioxidation, antitumor activity, modulation gut microbiota. We also impact on specific diseases cancer inflammatory bowel disease, highlighting importance addressing current production scalability, regulatory compliance, immunogenicity. Finally, proposed future research directions optimizing EV extraction developing targeted delivery systems. Through efforts, envision seamless integration into mainstream medicine, offering safe potent alternatives across various medical disciplines.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125118 - 125118
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
International Journal of Innovative Science and Research Technology (IJISRT), Год журнала: 2024, Номер unknown, С. 2621 - 2626
Опубликована: Ноя. 19, 2024
Microneedling, a minimally invasive technique involving the creation of microchannels in skin, has emerged as promising platform for vaccine delivery. The use microneedles vaccination represents new era immunization techniques, wherein patients no longer dread sharp pricks. Their breakthrough potential lies their ability to deliver vaccines directly into epidermis or dermis where high density immune cells improve particularly relevant effects vaccines. intro- duction met various challenges often experienced with traditional methods like bites caused by fear, pain from needles, even that any medical doctor may take long administer them. Microneedles could stability and lessen dependence on cold chain transport systems since they can be prepared dry form. In addition providing an al- ternative syringes, are also considered less painful than review highlights mi- croneedles rates, especially un- derserved populations, identifies key areas future research development.
Язык: Английский
Процитировано
0
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115478 - 115478
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0