Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1328 - 1328
Опубликована: Окт. 14, 2024
Artificial
intelligence
(AI)
encompasses
a
broad
spectrum
of
techniques
that
have
been
utilized
by
pharmaceutical
companies
for
decades,
including
machine
learning,
deep
and
other
advanced
computational
methods.
These
innovations
unlocked
unprecedented
opportunities
the
acceleration
drug
discovery
delivery,
optimization
treatment
regimens,
improvement
patient
outcomes.
AI
is
swiftly
transforming
industry,
revolutionizing
everything
from
development
to
personalized
medicine,
target
identification
validation,
selection
excipients,
prediction
synthetic
route,
supply
chain
optimization,
monitoring
during
continuous
manufacturing
processes,
or
predictive
maintenance,
among
others.
While
integration
promises
enhance
efficiency,
reduce
costs,
improve
both
medicines
health,
it
also
raises
important
questions
regulatory
point
view.
In
this
review
article,
we
will
present
comprehensive
overview
AI's
applications
in
covering
areas
such
as
discovery,
safety,
more.
By
analyzing
current
research
trends
case
studies,
aim
shed
light
on
transformative
impact
industry
its
broader
implications
healthcare.
Язык: Английский
Fabrication of Organ-on-a-Chip using Microfluidics
Bioprinting,
Год журнала:
2025,
Номер
unknown, С. e00394 - e00394
Опубликована: Янв. 1, 2025
Язык: Английский
Integration of 3D-printed micromixers and spray drying for pulmonary delivery of antimicrobial microparticles
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125493 - 125493
Опубликована: Март 1, 2025
Язык: Английский
Amphotericin B Ocular Films for Fungal Keratitis and a Novel 3D-Printed Microfluidic Ocular Lens Infection Model
Journal of Fungi,
Год журнала:
2024,
Номер
10(11), С. 762 - 762
Опубликована: Ноя. 2, 2024
Fungal
keratitis
(FK),
a
severe
eye
infection
that
leads
to
vision
impairment
and
blindness,
poses
high
risk
contact
lens
users,
Язык: Английский
Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of Melatonin Gel Formulations
Gels,
Год журнала:
2024,
Номер
10(9), С. 595 - 595
Опубликована: Сен. 16, 2024
Melatonin’s
antioxidant
properties
make
it
a
valuable
component
in
anti-aging
semisolid
topical
products.
This
study
explores
the
role
of
Pemulen®,
an
acrylic-based
viscosifying
agent,
stabilizing
cream-gel
formulations.
Remarkably,
even
at
low
concentrations
(0.4%),
Pemulen®
successfully
produced
physicochemical
stable
In
this
work,
impact
ratio
oily
phase—comprising
olive
oil
and
isopropyl
myristate
from
0
to
20%—was
investigated
understand
internal
microstructure
effect
on
skin
permeability,
rheological
properties,
stability.
The
formulations
exhibited
pseudoplastic
behavior,
with
significant
positive
correlation
(p-value
<
0.1)
between
phase
ratio,
viscosity,
spreadability,
adhesiveness,
permeability.
Formulations
without
greater
However,
higher
content
enhanced
adhesion.
Given
that
melatonin
primarily
degrades
through
oxidation,
incorporating
excipients
is
crucial
for
maintaining
its
chemical
A
quality
by
design
(QbD)
approach
was
used
assess
four
excipients—(a)
DL-α-tocopheryl
acetate
(0.05%),
(b)
ascorbic
acid
(0.1%),
(c)
ethylene
diamine
tetraacetic
(d)
sodium
metabisulphite
(0.5%)—on
melatonin’s
Our
findings
indicate
physical
stability
formulation
20%
more
critical
protecting
oxidation
than
merely
adding
excipients.
Язык: Английский