Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of Melatonin Gel Formulations DOI Creative Commons
Juan J. Torrado, Brayan J. Anaya, Aytug Kara

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 595 - 595

Published: Sept. 16, 2024

Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® successfully produced physicochemical stable In this work, impact ratio oily phase—comprising olive oil and isopropyl myristate from 0 to 20%—was investigated understand internal microstructure effect on skin permeability, rheological properties, stability. The formulations exhibited pseudoplastic behavior, with significant positive correlation (p-value < 0.1) between phase ratio, viscosity, spreadability, adhesiveness, permeability. Formulations without greater However, higher content enhanced adhesion. Given that melatonin primarily degrades through oxidation, incorporating excipients is crucial for maintaining its chemical A quality by design (QbD) approach was used assess four excipients—(a) DL-α-tocopheryl acetate (0.05%), (b) ascorbic acid (0.1%), (c) ethylene diamine tetraacetic (d) sodium metabisulphite (0.5%)—on melatonin’s Our findings indicate physical stability formulation 20% more critical protecting oxidation than merely adding excipients.

Language: Английский

Artificial Intelligence (AI) Applications in Drug Discovery and Drug Delivery: Revolutionizing Personalized Medicine DOI Creative Commons
Dolores R. Serrano,

Francis C. Luciano,

Brayan J. Anaya

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1328 - 1328

Published: Oct. 14, 2024

Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep and other advanced computational methods. These innovations unlocked unprecedented opportunities the acceleration drug discovery delivery, optimization treatment regimens, improvement patient outcomes. AI is swiftly transforming industry, revolutionizing everything from development to personalized medicine, target identification validation, selection excipients, prediction synthetic route, supply chain optimization, monitoring during continuous manufacturing processes, or predictive maintenance, among others. While integration promises enhance efficiency, reduce costs, improve both medicines health, it also raises important questions regulatory point view. In this review article, we will present comprehensive overview AI's applications in covering areas such as discovery, safety, more. By analyzing current research trends case studies, aim shed light on transformative impact industry its broader implications healthcare.

Language: Английский

Citations

37
Fabrication of Organ-on-a-Chip using Microfluidics DOI

S. Ying-Jin,

Iván Yuste, Elena González‐Burgos

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00394 - e00394

Published: Jan. 1, 2025

Language: Английский

Citations

0
Integration of 3D-printed micromixers and spray drying for pulmonary delivery of antimicrobial microparticles DOI
Brayan J. Anaya, Aytug Kara,

Rafaela Raposo

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125493 - 125493

Published: March 1, 2025

Language: Английский

Citations

0
Amphotericin B Ocular Films for Fungal Keratitis and a Novel 3D-Printed Microfluidic Ocular Lens Infection Model DOI Creative Commons

Chrysi Rapti,

Francis C. Luciano,

Brayan J. Anaya

et al.

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(11), P. 762 - 762

Published: Nov. 2, 2024

Fungal keratitis (FK), a severe eye infection that leads to vision impairment and blindness, poses high risk contact lens users,

Language: Английский

Citations

2
Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of Melatonin Gel Formulations DOI Creative Commons
Juan J. Torrado, Brayan J. Anaya, Aytug Kara

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 595 - 595

Published: Sept. 16, 2024

Melatonin’s antioxidant properties make it a valuable component in anti-aging semisolid topical products. This study explores the role of Pemulen®, an acrylic-based viscosifying agent, stabilizing cream-gel formulations. Remarkably, even at low concentrations (0.4%), Pemulen® successfully produced physicochemical stable In this work, impact ratio oily phase—comprising olive oil and isopropyl myristate from 0 to 20%—was investigated understand internal microstructure effect on skin permeability, rheological properties, stability. The formulations exhibited pseudoplastic behavior, with significant positive correlation (p-value < 0.1) between phase ratio, viscosity, spreadability, adhesiveness, permeability. Formulations without greater However, higher content enhanced adhesion. Given that melatonin primarily degrades through oxidation, incorporating excipients is crucial for maintaining its chemical A quality by design (QbD) approach was used assess four excipients—(a) DL-α-tocopheryl acetate (0.05%), (b) ascorbic acid (0.1%), (c) ethylene diamine tetraacetic (d) sodium metabisulphite (0.5%)—on melatonin’s Our findings indicate physical stability formulation 20% more critical protecting oxidation than merely adding excipients.

Language: Английский

Citations

0