Human in the Loop: Accelerating Pharmaceutical SLS 3D Printing Through Active Machine Learning DOI
Stephanie Cheung, Moe Elbadawi, Atheer Awad

и другие.

Опубликована: Янв. 1, 2023

Three-dimensional (3D) printing is an emerging fabrication technology that allows users greater control over their medicinal products. In particular, selective laser sintering (SLS), a subset of powder-based fusion, offers high resolution, solvent-free, minimal and simple pre-formulation steps. However, as new technology, limited number formulations have been explored thus far. Realising the full potential SLS will require large to be investigated, however, this invariably result in costly time-consuming endeavour. To address this, study introduces inventive machine learning (ML) strategy, Active ML, sustainably accelerate developments. ML operates by selectively identifying most critical test from overall unknown space, enhancing its efficiency. Among 1618 potentially SLS-printable thermoplastic amassed scientific literature internal databases were untested, two feature sets employed represent them: Material Name Physical Properties. working through five human-machine interactions, selected only 73 vast pool test. A subsequent validation using set accurately predicted six out eight formulations' printability, demonstrating extended formulation database 1800 whilst testing less than 5% formulations. This exemplifies ML's rapidly increase 3D space significantly decreasing trials. The advantage limitations implementation are discussed. Given these results, proposed methodology poised for widespread application emergent technologies, expediting development.

Язык: Английский

Inkjet Printing of Pharmaceuticals DOI Creative Commons
Paola Carou‐Senra, Lucía Rodríguez‐Pombo, Atheer Awad

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(11)

Опубликована: Ноя. 10, 2023

Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer-by-layer, to create 3D objects or 2D patterns with precise control over their structure and composition. This technology has emerged as attractive versatile approach address the ever-evolving demands of personalized medicine in healthcare industry. Although originally developed for nonhealthcare applications, IJP harnesses potential pharma-inks, which are meticulously formulated inks containing drugs pharmaceutical excipients. Delving into formulation components key adaptable material deposition enabled by unraveled. The review extends its focus substrate including paper, films, foams, lenses, 3D-printed showcasing diverse advantages, while exploring a wide spectrum therapeutic applications. Additionally, benefits hardware software improvements, along artificial intelligence integration, discussed enhance IJP's precision efficiency. Embracing these advancements, holds immense reshape traditional processes, ushering era medical precision. However, further exploration optimization needed fully utilize capabilities. As researchers push boundaries IJP, vision patient-specific treatment on horizon becoming tangible reality.

Язык: Английский

Процитировано

29
3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope DOI Creative Commons
Javed Ahmad, Anuj Garg, Gulam Mustafa

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1448 - 1448

Опубликована: Май 10, 2023

3D printing technology in medicine is gaining great attention from researchers since the FDA approved first 3D-printed tablet (Spritam®) on market. This technique permits fabrication of various types dosage forms with different geometries and designs. Its feasibility design pharmaceutical very promising for making quick prototypes because it flexible does not require expensive equipment or molds. However, development multi-functional drug delivery systems, specifically as solid loaded nanopharmaceuticals, has received recent years, although challenging formulators to convert them into a successful form. The combination nanotechnology field provided platform overcome challenges associated nanomedicine-based forms. Therefore, major focus present manuscript review research developments that involved formulation utilizing technology. Utilization techniques nanopharmaceuticals achieved transformation liquid polymeric nanocapsules self-nanoemulsifying systems (SNEDDS) such tablets suppositories easily customized doses per needs individual patient (personalized medicine). Furthermore, also highlights utility extrusion-based (Pressure-Assisted Microsyringe—PAM; Fused Deposition Modeling—FDM) produce containing nanocapsule SNEDDS oral rectal administration. critically analyzes contemporary related impact process parameters performance

Язык: Английский

Процитировано

24
Ensuring the quality of 3D printed medicines: Integrating a balance into a pharmaceutical printer for in-line uniformity of mass testing DOI Creative Commons
Carlos Bendicho-Lavilla, Lucía Rodríguez‐Pombo, Patricija Januskaite

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105337 - 105337

Опубликована: Янв. 2, 2024

Semi-solid extrusion (SSE) 3D printing has great potential to be integrated in a clinical setting, with the use of pre-filled and disposable pharma-ink syringes meeting regulatory good manufacturing practice (GMP) requirements. Uniformity mass testing is critical quality attribute carried out by weighing specific amount dosage units single batch finding average evaluate any deviations. However, this test for small batches printed medicines may require entire manufactured batch. To overcome limitation, an in-line analytical balance was implemented inside GMP pharmaceutical printer, specialised software-controlled system automated uniformity Three different dose (n = 28) hydrocortisone were subjected testing. The developed software capable registering weights all individual printlets accurately detecting deviations within accepted limits. Only one printlet outside weight range, result first print often being imperfect due semi-solid nature pharma-ink. results compared against external balance, no significant differences found. This study integrate automating form which can save time, labour, resources, whilst improving control pharmaceuticals.

Язык: Английский

Процитировано

14
Innovative Pharmaceutical Techniques for Paediatric Dosage Forms: A Systematic Review on 3D Printing, Prilling/Vibration and Microfluidic Platform DOI Creative Commons
Giuseppe Francesco Racaniello, Teresa Silvestri,

Monica Pistone

и другие.

Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 113(7), С. 1726 - 1748

Опубликована: Апрель 4, 2024

The production of paediatric pharmaceutical forms represents a unique challenge within the industry. primary goal these formulations is to ensure therapeutic efficacy, safety, and tolerability in patients, who have specific physiological needs characteristics. In recent years, there has been significant increase attention towards this area, driven by need improve drug administration children optimal treatments. Technological innovation played crucial role meeting requirements, opening new frontiers design forms. particular, three emerging technologies garnered considerable interest scientific industrial community: 3D printing, prilling/vibration, microfluidics. These offer advanced approaches for design, production, customization forms, allowing more precise dosage modulation, improved solubility, greater acceptability. review, we delve into cutting-edge their impact on We analyse potential, associated challenges, developments, providing comprehensive overview opportunities that innovative methodologies sector. examine different generated using techniques, evaluating advantages disadvantages.

Язык: Английский

Процитировано

14
The value of spray drying as stabilization process for proteins DOI
Katharina Tatjana Kopp,

Maarten De Beer,

Jody Voorspoels

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125422 - 125422

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
The Future of Medicine: How 3D Printing Is Transforming Pharmaceuticals DOI Creative Commons
Jurga Bernatonienė, Jolita Stabrauskiene, Jurga Andrėja Kazlauskaitė

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 390 - 390

Опубликована: Март 19, 2025

Three-dimensional printing technology is transforming pharmaceutical manufacturing by shifting from conventional mass production to additive manufacturing, with a strong emphasis on personalized medicine. The integration of bioinks and AI-driven optimization further enhancing this innovation, enabling drug precise dosages, tailored drug-release profiles, unique multi-drug combinations that respond individual patient needs. This advancement significantly impacting healthcare accelerating development, encouraging innovative designs, treatment efficacy. Traditional follows one-size-fits-all approach, which often fails meet the specific requirements patients medical conditions. In contrast, 3D printing, coupled bioink formulations, allows for on-demand production, reducing dependency large-scale storage. AI-powered design process refine dosage forms, printability, release mechanisms, ensuring precision efficiency in manufacturing. These advancements have potential lower overall costs while improving adherence medication regimens. review explores potential, challenges, environmental benefits positioning it as key driver next-generation

Язык: Английский

Процитировано

1
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release DOI Creative Commons

Elena Munoz-Perez,

Jorge Rubio‐Retama, Lorena Cussó

и другие.

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3385 - 3403

Опубликована: Янв. 7, 2024

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.

Язык: Английский

Процитировано

7
3D printing of pharmaceutical dosage forms: Recent advances and applications DOI Creative Commons

Auel Tobias,

Mentrup Aaron Felix Christofer,

Olivier Roy

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115504 - 115504

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

7
Drug delivery and testing via 3D printing DOI
Virender Kumar, Harmanpreet Kaur,

Anuradha Kumari

и другие.

Bioprinting, Год журнала: 2023, Номер 36, С. e00298 - e00298

Опубликована: Июль 27, 2023

Язык: Английский

Процитировано

15
3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the treatment of inflammatory bowel disease DOI Creative Commons
L.I. Kocabas, S. Ayyoubi, M. Tajqurishi

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 649, С. 123639 - 123639

Опубликована: Ноя. 30, 2023

Established medicines are often not tailored to the needs of pediatric population, causing difficulties with administration or dosing. Three-dimensional (3D) printing technology allows novel approaches for compounding personalized medicine, as is exemplified in this study automated rectal preparations children. We investigated material requirements print prednisolone phosphate-loaded suppositories tunable dose and rapid drug release treatment inflammatory bowel diseases. Three formulations containing 4 % w/w sodium phosphate (PSP) different amounts hydroxypropyl cellulose (HPC) mannitol excipients were printed a fused deposition modeling (FDM) 3D-printer. Dissolution studies showed that PSP rate was increased when higher weight fractions added pore former, 90 within 30 min 48 w/w. further infill densities dimensions tune dose. Our findings demonstrated 3D-printed doses ranging from 6 mg could be compounded without notably affecting dissolution kinetics, ensuring equivalent therapeutic efficacies doses.

Язык: Английский

Процитировано

10