International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137058 - 137058
Опубликована: Ноя. 3, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132123 - 132123
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
15
Carbohydrate Polymers, Год журнала: 2024, Номер 348, С. 122845 - 122845
Опубликована: Окт. 17, 2024
Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.
Язык: Английский
Процитировано
10
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер unknown, С. 115504 - 115504
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
6
Gels, Год журнала: 2025, Номер 11(4), С. 245 - 245
Опубликована: Март 26, 2025
Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.
Язык: Английский
Процитировано
0
European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 201, С. 106858 - 106858
Опубликована: Июль 20, 2024
Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as promising candidate sustained delivery. Despite its unique properties allow to load release proteins mitigating burst extending effects, precise control over Laponite-protein interactions remains challenging since it depends on complex interplay factors whose implication not fully understood yet. aim this review article shed light issue, providing comprehensive discussion the influencing protein loading release, including physicochemical nanoclay proteins, pH, dispersion buffer, clay/protein concentration degradation. Furthermore, we thoroughly revise bioactive that have been delivered from formulations containing nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, avenue currently under extensive investigation.
Язык: Английский
Процитировано
3
Journal of Bioactive and Compatible Polymers, Год журнала: 2024, Номер 39(3), С. 162 - 174
Опубликована: Март 17, 2024
As a microscale three-dimensional bionic model, microtissue array is promising method for disease modeling and drug screening. Digital light processing (DLP) 3D bio-printing technology with the capabilities of excellent printing speed resolution shows great potential fabricating arrays. However, outcomes arrays using DLP are limited by shortage biomaterials. In this work, we prepare hydrogel microtissues combining biphasic bio-ink consisting gelatin methacrylate (GelMA) dextran. GelMA/ dextran mixed to form bio-inks different volume ratios, which can achieve high-precision various patterns. Due presence dextran, internal porous structure in printed The pore size related proportion bio-inks, becomes smaller increase ratio. addition, adipose-derived stem cells (ADSCs) encapsulated hydrogels maintain high survival rate 98.01% after 3 days culture, larger promotes cell migration. Combining system allows multiple micro-size geometric pattern be simultaneously study, new suitable proposed, simple, accurate, high-throughput biological manufacturing developed, thus providing valuable tool screening tissue engineering.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137058 - 137058
Опубликована: Ноя. 3, 2024
Язык: Английский
Процитировано
0