AJP Lung Cellular and Molecular Physiology,
Год журнала:
2011,
Номер
301(4), С. L415 - L426
Опубликована: Июль 16, 2011
Molecular
hydrogen
(H(2))
is
an
efficient
antioxidant
that
diffuses
rapidly
across
cell
membranes,
reduces
reactive
oxygen
species
(ROS),
such
as
hydroxyl
radicals
and
peroxynitrite,
suppresses
oxidative
stress-induced
injury
in
several
organs.
ROS
have
been
implicated
radiation-induced
damage
to
lungs.
Because
prompt
elimination
of
irradiation-induced
should
protect
lung
tissue
from
damaging
effects
irradiation,
we
investigated
the
possibility
H(2)
could
serve
a
radioprotector
lung.
Cells
human
epithelial
line
A549
received
10
Gy
irradiation
with
or
without
treatment
via
H(2)-rich
PBS
medium.
We
studied
possible
radioprotective
by
analyzing
damage.
Also,
C57BL/6J
female
mice
15
thorax.
Treatment
groups
inhaled
3%
gas
drank
H(2)-enriched
water.
evaluated
acute
late-irradiation
after
treatment.
reduced
amount
cells,
shown
electron
spin
resonance
fluorescent
indicator
signals.
also
damage,
measured
levels
stress
apoptotic
markers,
improved
viability.
Within
1
wk
whole
thorax
immunohistochemistry
immunoblotting
showed
apoptosis,
measures
lungs
mice.
At
5
mo
chest
computed
tomography,
Ashcroft
scores,
type
III
collagen
deposition
demonstrated
fibrosis
(late
damage).
This
study
thus
valuable
for
protection
against
no
known
toxicity.
Experimental Dermatology,
Год журнала:
2008,
Номер
17(9), С. 713 - 730
Опубликована: Июль 17, 2008
Abstract:
Melatonin,
one
of
the
evolutionarily
most
ancient,
highly
conserved
and
pleiotropic
hormones
still
operative
in
man,
couples
complex
tissue
functions
to
defined
changes
environment.
Showing
photoperiod‐associated
its
activity
levels
mammals,
melatonin
regulates,
chronobiological
reproductive
systems,
coat
phenotype
mammary
gland
functions.
However,
this
chief
secretory
product
pineal
is
now
recognized
also
exert
numerous
additional
which
range
from
free
radical
scavenging
DNA
repair
via
immunomodulation,
body
weight
control
promotion
wound
healing
coupling
environmental
cues
circadian
clock
gene
expression
modulation
secondary
endocrine
signalling
(e.g.
prolactin
release,
oestrogen
receptor‐mediated
signalling).
Some
these
activities
are
mediated
by
high‐affinity
membrane
(MT1,
MT2)
or
specific
cytosolic
(MT3/NQO2)
nuclear
hormone
receptors
(RORα),
while
others
reflect
receptor‐independent
antioxidant
melatonin.
Recently,
it
was
shown
that
mammalian
(including
human)
skin
hair
follicles
not
only
targets,
but
sites
extrapineal
synthesis.
Therefore,
we
provide
here
an
update
relevant
cutaneous
effects
mechanisms
melatonin,
portray
as
a
major
protectant
sketch
how
multi‐facetted
may
impact
on
biology
pathology.
This
illustrated
focussing
recent
findings
role
photodermatology
follicle
biology.
After
listing
number
key
open
questions,
conclude
defining
particularly
important,
clinically
perspectives
for
become
therapeutically
exploitable
medicine.
Journal of Radiation Research,
Год журнала:
2007,
Номер
48(4), С. 263 - 272
Опубликована: Янв. 1, 2007
In
spite
of
the
fact
that
radiotherapy
is
a
common
and
effective
tool
for
cancer
treatment;
radio
sensitivity
normal
tissues
adjacent
to
tumor
which
are
unavoidably
exposed
radiation
limits
therapeutic
gain.
For
sake
improvement
in
therapy,
radiobiology-
study
action
ionizing
on
living
things-
plays
crucial
role
through
explaining
observed
phenomena,
suggesting
improvements
existing
therapies.
Due
damaging
effects
radiation,
radiobiologists
have
long
been
interested
identifying
novel,
nontoxic,
effective,
convenient
compounds
protect
humans
against
induced
tissue
injuries.
hundreds
investigations,
melatonin
(N-acetyl-5-methoxytryptamine),
chief
secretory
product
pineal
gland
brain,
has
documented
ameliorate
oxidative
injuries
due
radiation.
This
article
reviews
different
features
make
potentially
useful
radioprotector.
Moreover,
based
radiobiological
models
we
can
hypothesize
may
postpone
saturation
repair
enzymes
leads
repairing
more
damage
by
system
importantly
allows
use
higher
doses
during
get
better
ratio.
The
implications
accumulated
observations
suggest
virtue
melatonin's
radioprotective
anticancer
effects;
it
time
as
radioprotector
both
workers
patients
suffering
from
either
alone
inhibition
or
combination
with
traditional
getting
favorable
efficacy/toxicity
ratio
treatment.
Although
compelling
evidence
suggests
be
variety
disorders,
optimum
dose
human
radioprotection
yet
determined.
We
propose
that,
future,
improve
oncology.
AJP Lung Cellular and Molecular Physiology,
Год журнала:
2011,
Номер
301(4), С. L415 - L426
Опубликована: Июль 16, 2011
Molecular
hydrogen
(H(2))
is
an
efficient
antioxidant
that
diffuses
rapidly
across
cell
membranes,
reduces
reactive
oxygen
species
(ROS),
such
as
hydroxyl
radicals
and
peroxynitrite,
suppresses
oxidative
stress-induced
injury
in
several
organs.
ROS
have
been
implicated
radiation-induced
damage
to
lungs.
Because
prompt
elimination
of
irradiation-induced
should
protect
lung
tissue
from
damaging
effects
irradiation,
we
investigated
the
possibility
H(2)
could
serve
a
radioprotector
lung.
Cells
human
epithelial
line
A549
received
10
Gy
irradiation
with
or
without
treatment
via
H(2)-rich
PBS
medium.
We
studied
possible
radioprotective
by
analyzing
damage.
Also,
C57BL/6J
female
mice
15
thorax.
Treatment
groups
inhaled
3%
gas
drank
H(2)-enriched
water.
evaluated
acute
late-irradiation
after
treatment.
reduced
amount
cells,
shown
electron
spin
resonance
fluorescent
indicator
signals.
also
damage,
measured
levels
stress
apoptotic
markers,
improved
viability.
Within
1
wk
whole
thorax
immunohistochemistry
immunoblotting
showed
apoptosis,
measures
lungs
mice.
At
5
mo
chest
computed
tomography,
Ashcroft
scores,
type
III
collagen
deposition
demonstrated
fibrosis
(late
damage).
This
study
thus
valuable
for
protection
against
no
known
toxicity.
