AJP Cell Physiology,
Год журнала:
2020,
Номер
319(2), С. C258 - C267
Опубликована: Июнь 8, 2020
Because
of
the
ongoing
pandemic
around
world,
mechanisms
underlying
SARS-CoV-2-induced
COVID-19
are
subject
to
intense
investigation.
Based
on
available
data
for
SARS-CoV-1
virus,
we
suggest
how
CoV-2
localization
RNA
transcripts
in
mitochondria
hijacks
host
cell’s
mitochondrial
function
viral
advantage.
Besides
transcripts,
also
localizes
mitochondria.
SARS-CoV-2
may
manipulate
indirectly,
first
by
ACE2
regulation
function,
and
once
it
enters
cell,
open-reading
frames
(ORFs)
such
as
ORF-9b
can
directly
evade
cell
immunity
facilitate
virus
replication
disease.
Manipulations
ORFs
release
DNA
(mtDNA)
cytoplasm
activate
mtDNA-induced
inflammasome
suppress
innate
adaptive
immunity.
We
argue
that
a
decline
aged
individuals,
coupled
with
age-associated
functions
resulting
chronic
metabolic
disorders
like
diabetes
or
cancer,
make
more
vulnerable
infection
health
complications
mortality.
These
observations
distinct
proteins
must
play
essential
roles
pathogenesis.
Understanding
communication
provide
critical
insights
into
pathologies.
An
investigation
hijacking
should
lead
novel
approaches
prevent
treat
COVID-19.
Cell Research,
Год журнала:
2017,
Номер
28(3), С. 265 - 280
Опубликована: Дек. 8, 2017
Glycolysis
has
long
been
considered
as
the
major
metabolic
process
for
energy
production
and
anabolic
growth
in
cancer
cells.
Although
such
a
view
instrumental
development
of
powerful
imaging
tools
that
are
still
used
clinics,
it
is
now
clear
mitochondria
play
key
role
oncogenesis.
Besides
exerting
central
bioenergetic
functions,
provide
indeed
building
blocks
tumor
anabolism,
control
redox
calcium
homeostasis,
participate
transcriptional
regulation,
govern
cell
death.
Thus,
constitute
promising
targets
novel
anticancer
agents.
However,
tumors
arise,
progress,
respond
to
therapy
context
an
intimate
crosstalk
with
host
immune
system,
many
immunological
functions
rely
on
intact
mitochondrial
metabolism.
Here,
we
review
cell-intrinsic
cell-extrinsic
mechanisms
through
which
influence
all
steps
oncogenesis,
focus
therapeutic
potential
targeting
metabolism
therapy.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Окт. 16, 2018
Aging
is
the
progressive
loss
of
organ
and
tissue
function
over
time.
Growing
older
positively
linked
to
cognitive
biological
degeneration
such
as
physical
frailty,
psychological
impairment,
decline.
Oxidative
stress
considered
an
imbalance
between
pro-
antioxidant
species,
which
results
in
molecular
cellular
damage.
plays
a
crucial
role
development
age-related
diseases.
Emerging
research
evidence
has
suggested
that
can
control
autoxidation
by
interrupting
propagation
free
radicals
or
inhibiting
formation
subsequently
reduce
oxidative
stress,
improve
immune
function,
increase
healthy
longevity.
Indeed,
oxidation
damage
highly
dependent
on
inherited
acquired
defects
enzymes
involved
redox-mediated
signaling
pathways.
Therefore,
molecules
with
activity
promote
aging
counteract
worth
discuss
further.
Of
particular
interest
this
article,
we
highlighted
mechanisms
antioxidants
prevention
Taken
together,
better
understanding
redox
modulation
inflammation
would
provide
useful
approach
for
potential
interventions,
promoting
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Июнь 20, 2022
Abstract
In
recent
years,
immunotherapy
represented
by
immune
checkpoint
inhibitors
(ICIs)
has
led
to
unprecedented
breakthroughs
in
cancer
treatment.
However,
the
fact
that
many
tumors
respond
poorly
or
even
not
ICIs,
partly
caused
absence
of
tumor-infiltrating
lymphocytes
(TILs),
significantly
limits
application
ICIs.
Converting
these
“cold”
into
“hot”
may
ICIs
is
an
unsolved
question
immunotherapy.
Since
it
a
general
characteristic
cancers
resist
apoptosis,
induction
non-apoptotic
regulated
cell
death
(RCD)
emerging
as
new
treatment
strategy.
Recently,
several
studies
have
revealed
interaction
between
RCD
and
antitumor
immunity.
Specifically,
autophagy,
ferroptosis,
pyroptosis,
necroptosis
exhibit
synergistic
responses
while
possibly
exerting
inhibitory
effects
on
responses.
Thus,
targeted
therapies
(inducers
inhibitors)
against
combination
with
exert
potent
activity,
resistant
This
review
summarizes
multilevel
relationship
immunity
RCD,
including
necroptosis,
potential
targeting
improve
efficacy
malignancy.
