Journal of Allergy and Clinical Immunology,
Год журнала:
2016,
Номер
139(1), С. 166 - 172
Опубликована: Сен. 9, 2016
Disease
flares
of
established
atopic
dermatitis
(AD)
are
generally
associated
with
a
low-diversity
skin
microbiota
and
Staphylococcus
aureus
dominance.
The
temporal
transition
the
microbiome
between
early
infancy
dysbiosis
AD
is
unknown.We
randomly
selected
50
children
from
Cork
Babies
After
SCOPE:
Evaluating
Longitudinal
Impact
Using
Neurological
Nutritional
Endpoints
(BASELINE)
longitudinal
birth
cohort
for
sampling
at
3
points
in
first
6
months
life
4
sites
relevant
to
AD:
antecubital
popliteal
fossae,
nasal
tip,
cheek.
We
identified
10
infants
compared
them
control
no
AD.
performed
bacterial
16S
ribosomal
RNA
sequencing
analysis
directly
clinical
samples.Bacterial
community
structures
diversity
shifted
over
time,
suggesting
that
age
strongly
affects
infants.
Unlike
AD,
these
patients
infantile
did
not
have
noticeably
dysbiotic
communities
before
or
disease
were
colonized
by
S
aureus.
In
comparing
subjects,
who
had
affected
month
12
statistically
significant
differences
on
fossa
2
unaffected
12.
particular,
commensal
staphylococci
significantly
less
abundant
12,
this
genus
might
protect
against
later
development
AD.This
study
suggests
12-month-old
having
Additional
studies
needed
confirm
whether
colonization
modulates
immunity
attenuates
Cell Research,
Год журнала:
2020,
Номер
30(6), С. 492 - 506
Опубликована: Май 20, 2020
Abstract
The
interplay
between
the
commensal
microbiota
and
mammalian
immune
system
development
function
includes
multifold
interactions
in
homeostasis
disease.
microbiome
plays
critical
roles
training
of
major
components
host’s
innate
adaptive
system,
while
orchestrates
maintenance
key
features
host-microbe
symbiosis.
In
a
genetically
susceptible
host,
imbalances
microbiota-immunity
under
defined
environmental
contexts
are
believed
to
contribute
pathogenesis
multitude
immune-mediated
disorders.
Here,
we
review
microbiome-immunity
crosstalk
their
health
disease,
providing
examples
molecular
mechanisms
orchestrating
these
intestine
extra-intestinal
organs.
We
highlight
aspects
current
knowledge,
challenges
limitations
achieving
causal
understanding
host
immune-microbiome
interactions,
as
well
impact
on
diseases,
discuss
how
insights
may
translate
towards
future
microbiome-targeted
therapeutic
interventions.
Science,
Год журнала:
2016,
Номер
352(6285), С. 539 - 544
Опубликована: Апрель 28, 2016
Microbial
colonization
of
mucosal
tissues
during
infancy
plays
an
instrumental
role
in
the
development
and
education
host
mammalian
immune
system.
These
early-life
events
can
have
long-standing
consequences:
facilitating
tolerance
to
environmental
exposures
or
contributing
disease
later
life,
including
inflammatory
bowel
disease,
allergy,
asthma.
Recent
studies
begun
define
a
critical
period
early
which
disruption
optimal
host-commensal
interactions
lead
persistent
some
cases
irreversible
defects
training
specific
subsets.
Here,
we
discuss
system
this
“window
opportunity,”
when
microbial
has
potentially
impact
on
human
health
disease.
The Journal of Experimental Medicine,
Год журнала:
2018,
Номер
216(1), С. 20 - 40
Опубликована: Окт. 15, 2018
Over
the
past
decade,
our
view
of
human-associated
microbes
has
expanded
beyond
that
a
few
species
toward
an
appreciation
diverse
and
niche-specialized
microbial
communities
develop
in
human
host
with
chronological
age.
The
largest
reservoir
exists
distal
gastrointestinal
tract,
both
lumen,
where
facilitate
primary
secondary
metabolism,
on
mucosal
surfaces,
they
interact
immune
cell
populations.
While
local
microbial-driven
immunomodulation
gut
is
well
described,
more
recent
studies
have
demonstrated
role
for
microbiome
influencing
remote
organs
hematopoietic
function.
Unsurprisingly,
therefore,
perturbation
to
composition
function
microbiota
been
associated
chronic
diseases
ranging
from
inflammatory
metabolic
conditions
neurological,
cardiovascular,
respiratory
illnesses.
Considerable
effort
currently
focused
understanding
natural
history
development
humans
context
health
outcomes,
parallel
improving
knowledge
microbiome-host
molecular
interactions.
These
efforts
ultimately
aim
effective
approaches
rehabilitate
perturbed
ecosystems
as
means
restore
or
prevent
disease.
This
review
details
modulating
focus
discusses
strategies
manipulating
management
prevention
conditions.
Biomolecules,
Год журнала:
2021,
Номер
11(5), С. 700 - 700
Опубликована: Май 8, 2021
Skin
wounds
greatly
affect
the
global
healthcare
system,
creating
a
substantial
burden
on
economy
and
society.
Moreover,
situation
is
exacerbated
by
low
healing
rates,
which
in
fact
are
overestimated
reports.
Cutaneous
generally
classified
into
acute
chronic.
The
immune
response
plays
an
important
role
during
wound
healing.
activation
of
cells
factors
initiate
inflammatory
process,
facilitate
cleansing
promote
subsequent
tissue
However,
dysregulation
system
process
leads
to
persistent
inflammation
delayed
healing,
ultimately
result
chronic
wounds.
microenvironment
characterized
high
quantities
pro-inflammatory
macrophages,
overexpression
mediators
such
as
TNF-α
IL-1β,
increased
activity
matrix
metalloproteinases
abundance
reactive
oxygen
species.
frequently
complicated
bacterial
biofilms,
perpetuate
phase.
Continuous
microbial
biofilms
make
it
very
difficult
for
heal.
In
this
review,
we
discuss
innate
adaptive
immunity
pathogenesis
Furthermore,
review
latest
immunomodulatory
therapeutic
strategies,
including
modifying
macrophage
phenotype,
regulating
miRNA
expression
targeting
pro-
anti-inflammatory
improve
