Communications Biology,
Год журнала:
2021,
Номер
4(1)
Опубликована: Фев. 18, 2021
Abstract
SARS-CoV-2
is
the
cause
of
COVID-19.
It
infects
multiple
organs
including
respiratory
tract
and
gut.
Dynamic
changes
regional
microbiomes
in
infected
adults
are
largely
unknown.
Here,
we
performed
longitudinal
analyses
throat
anal
swabs
from
35
COVID-19
19
healthy
adult
controls,
as
well
10
non-COVID-19
patients
with
other
diseases,
by
16
S
rRNA
gene
sequencing.
The
results
showed
a
partitioning
into
3-4
categories
based
on
microbial
community
types
(I-IV)
both
sites.
bacterial
diversity
was
lower
than
controls
decreased
gradually
type
I
to
III/IV.
Although
dynamic
change
microbiome
complex
during
COVID-19,
synchronous
restoration
upper
gut
early
dysbiosis
towards
late
more
diverse
status
observed
6/8
mild
patients.
These
findings
reveal
previously
unknown
interactions
between
Clinical Microbiology Reviews,
Год журнала:
2019,
Номер
33(1)
Опубликована: Ноя. 12, 2019
Aspergillus
fumigatus
is
a
saprotrophic
fungus;
its
primary
habitat
the
soil.
In
ecological
niche,
fungus
has
learned
how
to
adapt
and
proliferate
in
hostile
environments.
This
capacity
helped
resist
survive
against
human
host
defenses
and,
further,
be
responsible
for
one
of
most
devastating
lung
infections
terms
morbidity
mortality.
Cellular Microbiology,
Год журнала:
2018,
Номер
20(12), С. e12966 - e12966
Опубликована: Окт. 17, 2018
The
pulmonary
microbial
community,
described
only
a
few
years
ago,
forms
discreet
part
of
the
human
host
microbiota.
airway
microbiota
has
been
found
to
be
substantially
altered
in
context
numerous
respiratory
disorders;
nonetheless,
its
role
health
and
disease
is
as
yet
poorly
understood.
Another
important
parameter
consider
gut-lung
axis,
where
distal
(gut)
immune
modulation
during
mediated
by
gut
use
specific
strains,
termed
"probiotics,"
with
beneficial
effects
on
immunity
and/or
against
pathogens,
proven
successful
treatment
intestinal
disorders
also
showing
promise
diseases.
In
this
review,
we
highlight
body's
commensal
bacteria
infectious
diseases,
including
recent
evidence
highlighting
their
local
(lung)
or
contribution
process.
ACS Applied Materials & Interfaces,
Год журнала:
2019,
Номер
11(21), С. 19495 - 19505
Опубликована: Май 6, 2019
Rapid
and
early
diagnosis
of
respiratory
viruses
is
key
to
preventing
infections
from
spreading
guiding
treatments.
Here,
we
developed
a
sensitive
quantitative
surface-enhanced
Raman
scattering-based
lateral
flow
immunoassay
(SERS-based
LFIA)
strip
for
simultaneous
detection
influenza
A
H1N1
virus
human
adenovirus
(HAdV)
by
using
Fe3O4@Ag
nanoparticles
as
magnetic
SERS
nanotags.
The
new
type
tags,
which
were
conjugated
with
dual-layer
dye
molecules
target
virus-capture
antibodies,
performs
the
following
functions:
specific
recognition
enrichment
in
solution
on
strip.
Based
this
strategy,
can
directly
be
used
real
biological
samples
without
any
sample
pretreatment
steps.
limits
HAdV
50
10
pfu/mL,
respectively,
2000
times
more
than
those
standard
colloidal
gold
method.
Moreover,
proposed
easy
operate,
rapid,
stable,
achieve
high
throughput
thus
potential
tool
infection.
Frontiers in Immunology,
Год журнала:
2020,
Номер
11
Опубликована: Фев. 21, 2020
The
emerging
concept
of
microbiota
contributing
to
local
mucosal
homeostasis
has
fueled
investigation
into
its
specific
role
in
immunology.
Gut
is
mostly
responsible
for
maintaining
the
balance
between
host
defense
and
immune
tolerance.
Dysbiosis
gut
been
shown
be
related
various
alterations
system.
This
review
focuses
on
reciprocal
relationship
innate
immunity
compartment,
with
emphasis
gut-associated
lymphoid
tissue,
cells,
phagocytes.
From
a
clinical
perspective,
gives
possible
explanation
how
"gut
microbiota-innate
immunity"
axis
might
contribute
pathogenesis
autoimmune
diseases
like
rheumatoid
arthritis,
spondyloarthritis,
systemic
lupus
erythematosus.
