Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Germinal center-dependent and -independent immune responses of tumor-infiltrating B cells in human cancers

Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(9), С. 1040 - 1050

Опубликована: Июль 7, 2023

B cells play essential roles in immunity, mainly through the production of high affinity plasma (PCs) and memory (Bmem) cells. The maturation differentiation rely on integration B-cell receptor (BCR) intrinsic extrinsic signals provided by antigen binding microenvironment, respectively. In recent years, tumor infiltrating (TIL-B) PCs (TIL-PCs) have been revealed as important players antitumor responses human cancers, but their interplay dynamics remain largely unknown. lymphoid organs, involve both germinal center (GC)-dependent GC-independent pathways for Bmem cell PC production. Affinity BCR repertoires occurs GC reactions with specific spatiotemporal signal general, reactivation high-affinity antigens triggers large numbers without rediversification. Understanding immune requires multiple tools readouts such single-cell phenotyping RNA-seq, situ analyses, repertoire analysis, specificity assays, functional tests. Here, we review how those recently applied to study TIL-B TIL-PC different types solid tumors. We assessed published evidence models TIL-B-cell involving GC-dependent or local resulting antigen-specific PCs. Altogether, highlight need more integrative immunology studies rationally investigate a leverage therapies.

Язык: Английский

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Tissue-resident immune cells: from defining characteristics to roles in diseases

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 16, 2025

Tissue-resident immune cells (TRICs) are a highly heterogeneous and plastic subpopulation of that reside in lymphoid or peripheral tissues without recirculation. These endowed with notably distinct capabilities, setting them apart from their circulating leukocyte counterparts. Many studies demonstrate complex roles both health disease, involving the regulation homeostasis, protection, destruction. The advancement tissue-resolution technologies, such as single-cell sequencing spatiotemporal omics, provides deeper insights into cell morphology, characteristic markers, dynamic transcriptional profiles TRICs. Currently, reported TRIC population includes tissue-resident T cells, memory B (BRM) innate lymphocytes, macrophages, neutrophils (TRNs), mast but unignorably existence TRNs is controversial. Previous focus on one specific diseases, however, origins, developmental trajectories, intercellular cross-talks every type not fully summarized. In addition, systemic overview TRICs disease progression development parallel therapeutic strategies lacking. Here, we describe function characteristics all types major diseases. We shed light how to harness offer new targets present burning questions this field.

Язык: Английский

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Macrophages direct location-dependent recall of B cell memory to vaccination

Cell, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Vaccines generate long-lived plasma cells and memory B (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their cell receptor upon boosting re-exposure antigen. We show in mouse models lymph nodes draining the site of primary vaccination harbor a subset Bmems reside subcapsular niche, larger recall responses, are more likely GCs compared with circulating non-draining nodes. This location-dependent into GC node was dependent on CD169+ sinus macrophages (SSMs) niche. In human participants, BNT162b2 vaccine same arm generated rapid secretion broadly neutralizing antibodies, participation, clonal expansion SARS-CoV-2-specific than opposite arm. These data reveal an unappreciated role for primed SSMs Bmem fate determination.

Язык: Английский

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T-cell–B-cell collaboration in the lung

Current Opinion in Immunology, Год журнала: 2023, Номер 81, С. 102284 - 102284

Опубликована: Фев. 7, 2023

Collaboration between T and B cells in secondary lymphoid organs is a crucial component of adaptive immunity, but lymphocytes also persist other tissues. Recent studies have examined T-cell–B-cell interactions nonlymphoid tissues such as the lung. CD4+ T- resident helper (TRH) remain lung after influenza infection support both CD8 cells. Multiple lung-resident B-cell subsets (B-resident memory (BRM)) that exhibit spatial phenotypic diversity been described. Though not generated by all types infection, inducible bronchus-associated tissue offers logical place for to interact. Perturbations BRM TRH elicit effects specific Immunoglobulin A (IgA) production, an antibody isotype with privileged access mucosa. Understanding interplay mucosal tissues, which can be insulated from systemic immune responses, may improve design future vaccines therapies.

Язык: Английский

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Memory B‐cell diversity: From early generation to tissue residency and reactivation

European Journal of Immunology, Год журнала: 2023, Номер 53(4)

Опубликована: Фев. 22, 2023

Memory B cells (MBCs) have a crucial function in providing an enhanced response to repeated infections. Upon antigen encounter, MBC can either rapidly differentiate antibody secreting or enter germinal centers (GC) further diversify and affinity mature. Understanding how when are formed, where they reside select their fate upon reactivation has profound implications for designing strategies improve targeted, next-generation vaccines. Recent studies crystallized much of our knowledge on but also reported several surprising discoveries gaps current understanding. Here, we review the latest advancements field highlight unknowns. In particular, focus timing cues leading generation before during GC reaction, discuss become resident mucosal tissues, finally, provide overview factors shaping fate-decision lymphoid tissues.

Язык: Английский

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Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses

Immunity, Год журнала: 2023, Номер 56(10), С. 2358 - 2372.e5

Опубликована: Сен. 11, 2023

Язык: Английский

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Regulation of pulmonary plasma cell responses during secondary infection with influenza virus

The Journal of Experimental Medicine, Год журнала: 2024, Номер 221(7)

Опубликована: Апрель 25, 2024

During secondary infection with influenza virus, plasma cells (PCs) develop within the lung, providing a local source of antibodies. However, site and mechanisms that regulate this process are poorly defined. Here, we show while circulating memory B entered lung during rechallenge were activated inducible bronchus-associated lymphoid tissues (iBALTs), resident (BRM) responded earlier, their activation occurred in different niche: directly near infected alveoli. This required NK but was largely independent CD4 CD8 T cells. Innate stimuli induced by virus-like particles containing ssRNA triggered BRM cell differentiation absence cognate antigen, suggesting low threshold activation. In contrast, expansion PCs iBALTs took longer to critically dependent on Our work demonstrates spatially distinct evolved support pulmonary PC responses, it reveals specialized function for as guardians

Язык: Английский

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Atypical B cells consist of subsets with distinct functional profiles

iScience, Год журнала: 2023, Номер 26(12), С. 108496 - 108496

Опубликована: Ноя. 20, 2023

Atypical B cells are a population of activated that commonly enriched in individuals with chronic immune activation but also part normal response to infection or vaccination. To better define the role atypical human adaptive response, we performed single-cell sequencing transcriptomes, cell surface markers, and receptors exposure malaria parasite

Язык: Английский

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Mucosal Immunity against SARS-CoV-2 in the Respiratory Tract

Pathogens, Год журнала: 2024, Номер 13(2), С. 113 - 113

Опубликована: Янв. 26, 2024

The respiratory tract, the first-line defense, is constantly exposed to inhaled allergens, pollutants, and pathogens such as viruses. Emerging evidence has demonstrated that coordination of innate adaptive immune responses in tract plays a crucial role protection against invading pathogens. Therefore, better understanding mucosal immunity airways critical for development novel therapeutics next-generation vaccines severe acute syndrome coronavirus 2 (SARS-CoV-2) other Since disease 2019 pandemic, our knowledge expanded. In this review, we describe latest regarding key components system tract. addition, summarize host upper lower following SARS-CoV-2 infection vaccination, discuss impact allergic airway inflammation on SARS-CoV-2.

Язык: Английский

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