B cell diversification in gut-associated lymphoid tissues: From birds to humans DOI Creative Commons
Jean‐Claude Weill, Sandra Weller, Claude‐Agnès Reynaud

et al.

The Journal of Experimental Medicine, Journal Year: 2023, Volume and Issue: 220(11)

Published: Sept. 29, 2023

Several species generate their preimmune repertoire in gut-associated lymphoid tissues (GALT), compensating a reduced germline V gene by post-rearrangement diversification mechanisms (gene conversion and/or somatic hypermutation) these environments that act as primary organs. We summarize here processes for three different (chickens, sheep, and rabbits) further discuss the analogous process T-independent B cell responses humans represent: we indeed recently showed response against bacterial polysaccharides mobilize marginal zone cells prediversified gut antigens. While initial strategy differs two cases, i.e., formation driven gut-derived mitotic signals vs. antigens, common feature of is mobilization compartment GALT immune distinct systemic

Language: Английский

Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract DOI
Alexander J Nelson, Bruna K. Tatematsu, Jordan R. Beach

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Germinal center-dependent and -independent immune responses of tumor-infiltrating B cells in human cancers DOI Creative Commons

Eve Playoust,

Romain Remark,

Éric Vivier

et al.

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 20(9), P. 1040 - 1050

Published: July 7, 2023

B cells play essential roles in immunity, mainly through the production of high affinity plasma (PCs) and memory (Bmem) cells. The maturation differentiation rely on integration B-cell receptor (BCR) intrinsic extrinsic signals provided by antigen binding microenvironment, respectively. In recent years, tumor infiltrating (TIL-B) PCs (TIL-PCs) have been revealed as important players antitumor responses human cancers, but their interplay dynamics remain largely unknown. lymphoid organs, involve both germinal center (GC)-dependent GC-independent pathways for Bmem cell PC production. Affinity BCR repertoires occurs GC reactions with specific spatiotemporal signal general, reactivation high-affinity antigens triggers large numbers without rediversification. Understanding immune requires multiple tools readouts such single-cell phenotyping RNA-seq, situ analyses, repertoire analysis, specificity assays, functional tests. Here, we review how those recently applied to study TIL-B TIL-PC different types solid tumors. We assessed published evidence models TIL-B-cell involving GC-dependent or local resulting antigen-specific PCs. Altogether, highlight need more integrative immunology studies rationally investigate a leverage therapies.

Language: Английский

Citations

20
Memory B‐cell diversity: From early generation to tissue residency and reactivation DOI Creative Commons

Laura Reusch,

Davide Angeletti

European Journal of Immunology, Journal Year: 2023, Volume and Issue: 53(4)

Published: Feb. 22, 2023

Memory B cells (MBCs) have a crucial function in providing an enhanced response to repeated infections. Upon antigen encounter, MBC can either rapidly differentiate antibody secreting or enter germinal centers (GC) further diversify and affinity mature. Understanding how when are formed, where they reside select their fate upon reactivation has profound implications for designing strategies improve targeted, next-generation vaccines. Recent studies crystallized much of our knowledge on but also reported several surprising discoveries gaps current understanding. Here, we review the latest advancements field highlight unknowns. In particular, focus timing cues leading generation before during GC reaction, discuss become resident mucosal tissues, finally, provide overview factors shaping fate-decision lymphoid tissues.

Language: Английский

Citations

14
Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses DOI Creative Commons

Nicole M. Arroyo-Díaz,

Holly Bachus, Amber M. Papillion

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2358 - 2372.e5

Published: Sept. 11, 2023

Language: Английский

Citations

14
T-cell–B-cell collaboration in the lung DOI Creative Commons

Wadschma Naderi,

David Schreiner, Carolyn G. King

et al.

Current Opinion in Immunology, Journal Year: 2023, Volume and Issue: 81, P. 102284 - 102284

Published: Feb. 7, 2023

Collaboration between T and B cells in secondary lymphoid organs is a crucial component of adaptive immunity, but lymphocytes also persist other tissues. Recent studies have examined T-cell–B-cell interactions nonlymphoid tissues such as the lung. CD4+ T- resident helper (TRH) remain lung after influenza infection support both CD8 cells. Multiple lung-resident B-cell subsets (B-resident memory (BRM)) that exhibit spatial phenotypic diversity been described. Though not generated by all types infection, inducible bronchus-associated tissue offers logical place for to interact. Perturbations BRM TRH elicit effects specific Immunoglobulin A (IgA) production, an antibody isotype with privileged access mucosa. Understanding interplay mucosal tissues, which can be insulated from systemic immune responses, may improve design future vaccines therapies.

Language: Английский

Citations

13
Regulation of pulmonary plasma cell responses during secondary infection with influenza virus DOI Creative Commons
Andrew J. MacLean, Joao P. P. Bonifacio, Sophia L. Oram

et al.

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(7)

Published: April 25, 2024

During secondary infection with influenza virus, plasma cells (PCs) develop within the lung, providing a local source of antibodies. However, site and mechanisms that regulate this process are poorly defined. Here, we show while circulating memory B entered lung during rechallenge were activated inducible bronchus-associated lymphoid tissues (iBALTs), resident (BRM) responded earlier, their activation occurred in different niche: directly near infected alveoli. This required NK but was largely independent CD4 CD8 T cells. Innate stimuli induced by virus-like particles containing ssRNA triggered BRM cell differentiation absence cognate antigen, suggesting low threshold activation. In contrast, expansion PCs iBALTs took longer to critically dependent on Our work demonstrates spatially distinct evolved support pulmonary PC responses, it reveals specialized function for as guardians

Language: Английский

Citations

4
Tissue-resident immune cells: from defining characteristics to roles in diseases DOI Creative Commons
Jia Li, Xiao Chu, Chunxiang Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 16, 2025

Tissue-resident immune cells (TRICs) are a highly heterogeneous and plastic subpopulation of that reside in lymphoid or peripheral tissues without recirculation. These endowed with notably distinct capabilities, setting them apart from their circulating leukocyte counterparts. Many studies demonstrate complex roles both health disease, involving the regulation homeostasis, protection, destruction. The advancement tissue-resolution technologies, such as single-cell sequencing spatiotemporal omics, provides deeper insights into cell morphology, characteristic markers, dynamic transcriptional profiles TRICs. Currently, reported TRIC population includes tissue-resident T cells, memory B (BRM) innate lymphocytes, macrophages, neutrophils (TRNs), mast but unignorably existence TRNs is controversial. Previous focus on one specific diseases, however, origins, developmental trajectories, intercellular cross-talks every type not fully summarized. In addition, systemic overview TRICs disease progression development parallel therapeutic strategies lacking. Here, we describe function characteristics all types major diseases. We shed light how to harness offer new targets present burning questions this field.

Language: Английский

Citations

0
The immune response to SARS-CoV-2 in COVID-19 as a recall response susceptible to immune imprinting: A prospective cohort study DOI Creative Commons
Daniel Álvarez‐Sierra, Mónica Martínez‐Gallo, Adrián Sánchez-Montalvà

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110429 - 110429

Published: Jan. 1, 2025

Language: Английский

Citations

0
Beyond circulating B cells: Characteristics and role of tissue-infiltrating B cells in systemic sclerosis DOI Creative Commons

Mathilde Le Maître,

Thomas Guerrier, S. Sangès

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(5), P. 103782 - 103782

Published: Feb. 24, 2025

B cells play a key role in the pathophysiology of systemic sclerosis (SSc). While they are less characterized than their circulating counterparts, tissue-infiltrating may have more direct pathological tissues. In this review, we decipher multiple evidence infiltration skin and lungs SSc patients animal models but also other chronic fibrotic diseases with similar mechanisms such as graft versus host disease, idiopathic pulmonary fibrosis or morphea. We recapitulate current knowledge about functions Finally, discuss cell targeted therapies, specific impact on infiltrated cells. Understanding local consequences infiltrating is an important step for better management improvement therapies SSc.

Language: Английский

Citations

0
Lung B cells in ectopic germinal centers undergo affinity maturation DOI Creative Commons
Stéphane M. Guillaume, William S. Foster, Isabel San Martín Molina

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(14)

Published: April 1, 2025

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within air. Chronic exposure allergens other airborne antigens can result in formation lymphocyte aggregates lung, which harbor ectopic germinal centers (GCs). After allergen exposure, GCs that form lung much smaller less densely packed with B cells than lymph node GCs. Despite this, support somatic hypermutation affinity-based maturation as GCs, export memory (MBCs) directly into tissue. This demonstrates locally diversify cell responses supports generation tissue MBC populations situ.

Language: Английский

Citations

0