Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 25, 2025
Cuproptosis,
a
novel
approach
utilizing
copper
carriers
to
trigger
programmed
cell
death,
exhibits
promise
for
enhancing
traditional
therapies
and
activating
robust
adaptive
immune
responses.
However,
the
uncontrolled
release
of
Cu
ions
risks
triggering
cuproptosis
in
healthy
tissues,
potentially
causing
irreversible
damage.
To
address
this,
we
report
on
use
Cu-MOF
(copper
metal-organic
framework)
protective
layer
regulate
biodegradation
copper-based
nanomaterials.
In
situ
formation
Cu2O
nanocubes
not
only
stabilizes
material
under
physiological
conditions
but
also
enhances
its
sonodynamic
therapy
(SDT)
capabilities
by
establishing
Z-Scheme
heterojunction.
Upon
SDT
activation,
targeted
ion
at
tumor
site
triggers
cascade
reactions,
generating
reactive
oxygen
species
(ROS)
via
Fenton-like
processes
depleting
glutathione
(GSH).
This
ROS
surge,
combined
with
effective
cuproptosis,
modulates
immunosuppressive
microenvironment,
inducing
immunogenic
death
eliminate
primary
tumors
inhibit
metastasis.
study
offers
new
paradigm
controlled
integration
SDT,
chemodynamic
(CDT),
immunotherapy,
achieving
precise
tumor-targeted
treatment
nanomaterial
degradation.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 27, 2024
Cuproptosis
is
a
novel
copper-dependent
programmed
cell
death.
The
efficacy
of
cuproptosis
highly
dependent
on
intracellular
copper
accumulation
and
counteracted
by
high
level
glutathione
(GSH)
in
tumor
cells.
Here,
this
work
develops
self-amplified
nanoparticles
(Cel-Cu
NP)
using
celastrol
(Cel),
natural
product
isolated
from
medical
plant.
In
Cel-Cu
NP,
Cel
serves
as
versatile
ionophore,
exhibiting
an
ideal
coordination
capacity
toward
ions
without
compromising
the
induction.
Notably,
can
simultaneously
scavenge
GSH
content
to
amplify
cuproptosis.
Moreover,
further
activates
immunogenic
death
(ICD)
elicit
robust
immune
response.
Combining
with
checkpoint
blockade,
NP
effectively
eradicates
metastatic
tumors
mouse
lung
metastasis
model.
This
study
provides
efficient
nanomedicine
inducing
for
immunotherapy.
Abstract
Cuproptosis,
an
emerging
form
of
programmed
cell
death,
has
received
tremendous
attention
in
cancer
therapy.
However,
the
efficacy
cuproptosis
remains
limited
by
poor
delivery
efficiency
copper
ion
carriers.
Herein,
complex
nanoparticles
(denoted
as
Cu(I)
NP)
are
developed
that
can
efficiently
deliver
into
cells
to
induce
cuproptosis.
NP
demonstrate
stimulus‐responsive
release
complexes,
which
results
mitochondrial
dysfunction
and
promotes
aggregation
lipoylated
dihydrolipoamide
S‐acetyltransferase
(DLAT),
leading
Notably,
not
only
cuproptosis,
but
also
elicit
robust
immune
responses
suppress
tumor
growth.
Overall,
this
study
provides
a
promising
strategy
for
cuproptosis‐based
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 1, 2024
Abstract
The
in
vivo
fate
of
chemotherapeutic
drugs
plays
a
vital
role
understanding
the
therapeutic
outcome,
side
effects,
and
mechanism.
However,
lack
imaging
abilities
drugs,
tedious
labeling
processes,
premature
leakage
agents
result
loss
fidelity
between
signals.
Herein,
an
amphiphilic
polymer
is
created
by
copolymerization
near‐infrared‐II
(NIR‐II)
fluorophore
tracer
(T)
anticancer
Pt(IV)
prodrug
(D)
cisplatin
hand‐holding
manner
into
one
chain
for
first
time.
obtained
Polyplatin
DT
capable
delivering
fluorophores
concomitantly
at
precise
D/T
ratio,
thereby
resulting
tracking
platinum
even
readout
them
real‐time
via
NIR‐II
imaging.
can
self‐assemble
nanoparticles,
referred
to
as
Nanoplatin
.
Furthermore,
caspase‐3
cleavable
peptide
that
serves
apoptosis
reporter
attached
,
DTR
are
simultaneously
evaluating
efficacy.
Overall,
it
reported
here
design
theranostic
with
drug
tracers,
efficacy
reporters
work
concert
provide
insight
mechanism
action.
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Abstract
Copper
plays
a
pivotal
role
in
human
physiology,
particularly
oncology,
acting
both
as
facilitator
of
progression
and
also
potential
avenue
for
advanced
therapeutic
approaches.
Maintaining
copper
homeostasis
is
crucial.
The
dysregulation
implicated
tumor
growth
through
its
involvement
critical
processes
angiogenesis,
proliferation,
metastasis.
elevation
level
the
microenvironment
(TME)
activates
oncogenic
pathways
to
drive
neovascularization
sustained
malignancies.
However,
same
reliance
on
offers
unique
weakness
that
can
be
leveraged
innovative
interventions.
recent
advances
nanomedicine
enable
synthesis
nanostructures
help
modulate
with
precision
offering
multifaceted
approaches
copper‐based
cancer
therapy
controlled
release
mechanism,
optimized
structures
induce
cuproptosis,
selective
eradication
cells
minimum
systemic
toxicity.
This
review
explores
dual
biology,
emphasizing
contribution
tumors
emerging
application
targeted
therapy.
highlights
harnessing
therapies
their
transformative
from
bench
bed
side
novel,
highly
effective,
clinical
safety.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
The
combination
of
cuproptosis
and
immune
checkpoint
inhibition
has
shown
promise
in
treating
malignant
tumors.
However,
it
remains
a
challenge
to
deliver
copper
ions
inhibitors
efficiently
simultaneously
Herein,
mitochondria-targeted
nanoscale
coordination
polymer
particle,
Cu/TI,
comprising
Cu(II),
triphenylphosphonium
conjugate
5-carboxy-8-hydroxyquinoline
(TI),
for
effective
induction
programmed
cell
death-1
(PD-L1)
downregulation
is
reported.
Upon
systemic
administration,
Cu/TI
accumulates
tumor
tissues
induce
immunogenic
cancer
death
reduce
PD-L1
expression.
Consequently,
promotes
the
intratumoral
infiltration
activation
cytotoxic
T
lymphocytes
greatly
inhibit
progression
colorectal
carcinoma
triple-negative
breast
mouse
models
without
causing
obvious
side
effects.
