Horticulture Research,
Год журнала:
2024,
Номер
11(2)
Опубликована: Янв. 2, 2024
Abstract
Artemisinin,
also
known
as
‘Qinghaosu’,
is
a
chemically
sesquiterpene
lactone
containing
an
endoperoxide
bridge.
Due
to
the
high
activity
kill
Plasmodium
parasites,
artemisinin
and
its
derivatives
have
continuously
served
foundation
for
antimalarial
therapies.
Natural
unique
traditional
Chinese
medicinal
plant
Artemisia
annua
L.,
content
in
this
low.
This
has
motivated
synthesis
of
bioactive
compound
using
yeast,
tobacco,
Physcomitrium
patens
systems.
However,
production
these
heterologous
hosts
low
cannot
fulfil
increasing
clinical
demand.
Therefore,
A.
plants
remain
major
source
component.
Recently,
transcriptional
regulatory
networks
related
biosynthesis
glandular
trichome
formation
been
extensively
studied
annua.
Various
strategies
including
(i)
enhancing
metabolic
flux
biosynthetic
pathway;
(ii)
blocking
competition
branch
pathways;
(iii)
transcription
factors
(TFs);
(iv)
peltate
secretory
(GST)
density;
(v)
applying
exogenous
factors;
(vi)
phytohormones
used
improve
yields.
Here
we
summarize
recent
scientific
advances
achievements
engineering,
discuss
prospects
development
high-artemisinin
yielding
varieties.
review
provides
new
insights
into
revealing
other
high-value
plant-derived
natural
compounds
(e.g.,
taxol,
vinblastine,
camptothecin),
well
formation.
It
helpful
researchers
who
intend
promote
species.
Plants,
Год журнала:
2023,
Номер
12(11), С. 2183 - 2183
Опубликована: Май 31, 2023
In
addition
to
the
naturopathic
medicines
based
on
antiseptic,
anti-inflammatory,
anticancer,
or
antioxidant
properties
of
plant
extracts
that
have
been
capitalized
upon
through
pharmaceutical
industry,
increasing
interest
food
industry
in
this
area
requires
potent
new
materials
capable
supporting
market.
This
study
aimed
evaluate
vitro
amino
acid
contents
and
activities
ethanolic
from
sixteen
plants.
Our
results
show
high
accumulated
contents,
mainly
proline,
glutamic,
aspartic
acid.
The
most
consistent
values
essential
acids
were
isolated
T.
officinale,
U.
dioica,
C.
majus,
A.
annua,
M.
spicata.
2,2-diphenyl-1-pycrylhydrazyl
(DPPH)
radical
scavenging
assay
indicate
R.
officinalis
was
antioxidant,
followed
by
four
other
(in
decreasing
order):
serpyllum,
monogyna,
S.
officinalis,
koenigii.
network
principal
component
analyses
found
natural
groupings
between
samples
DPPH
free
activity
content.
Each
extracts'
action
discussed
similar
literature,
a
lower
capacity
observed
for
species.
An
overall
ranking
analyzed
species
can
be
accomplished
due
range
experimental
methods.
literature
review
revealed
these
antioxidants
represent
best
side-effect-free
alternatives
synthetic
additives,
especially
processing
industry.
Frontiers in Plant Science,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 2, 2023
Artemisinin
is
a
secondary
metabolite
well-known
for
its
use
in
the
treatment
of
malaria.
It
also
displays
other
antimicrobial
activities
which
further
increase
interest.
At
present,
Artemisia
annua
sole
commercial
source
substance,
and
production
limited,
leading
to
global
deficit
supply.
Furthermore,
cultivation
A.
being
threatened
by
climate
change.
Specifically,
drought
stress
major
concern
plant
development
productivity,
but,
on
hand,
moderate
levels
can
elicit
metabolites,
with
putative
synergistic
interaction
elicitors
such
as
chitosan
oligosaccharides
(COS).
Therefore,
strategies
yield
has
prompted
much
With
this
aim,
effects
artemisinin
under
COS,
well
physiological
changes
plants
are
presented
study.Plants
were
separated
into
two
groups,
well-watered
(WW)
drought-stressed
(DS)
plants,
each
group,
four
concentrations
COS
applied
(0,
50,100
200
mg•L-1).
Afterwards,
water
was
imposed
withholding
irrigation
9
days.Therefore,
when
watered,
did
not
improve
growth,
upregulation
antioxidant
enzymes
hindered
artemisinin.
On
during
stress,
alleviate
decline
growth
at
any
concentration
tested.
However,
higher
doses
improved
status
since
leaf
potential
(YL)
50.64%
relative
content
(RWC)
33.84%
compared
DS
without
treatment.
Moreover,
combination
caused
damage
plant's
enzyme
defence,
particularly
APX
GR,
reduced
amount
phenols
flavonoids.
This
resulted
increased
ROS
enhanced
34.40%
treated
mg•L-1
control
plants.These
findings
underscore
critical
role
biosynthesis
suggest
that
may
boost
crop
production,
even
conditions.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
ADHs
are
key
genes
that
catalyze
the
interconversion
between
alcohols
and
aldehydes,
which
play
crucial
roles
in
plant
adaptation
to
a
range
of
abiotic
stresses.
However,
characterization
evolutionary
pathways
ADH
antimalarial
Artemisia
annua
still
unclear.
This
study
identified
49
A.
conducted
detailed
analysis
their
structural
features,
conserved
motifs,
duplication
types,
revealing
tandem
dispersed
duplications
primary
mechanisms
gene
expansion.
Evolutionary
(
AanADH
)
argyi
AarADH
revealed
dynamic
changes,
with
35
deriving
from
most
recent
common
ancestor
both
species.
ADH1
,
for
artemisinin
production,
had
two
copies
species,
expanding
via
but
whole-genome
.
CREs
WGCNA
suggested
may
be
regulated
by
UV-B
stress.
Following
short-term
treatment,
16
DEGs
were
identified,
including
AanADH6
AanADH7
),
these
significantly
downregulated
after
hours
treatment
(UV2h)
upregulated
four
(UV4h).
The
expression
changes
further
confirmed
GO
enrichment
qRT-PCR
experiments.
Overall,
this
comprehensively
characterized
family
systematically
responsive
stress,
providing
foundation
research
on
stress
responses.
Genus
Artemisia
has
diverse
phytochemistry
and
a
long
history
in
traditional
medicine
with
several
species
still
having
unexplored
potential.
Hence,
comparative
profiling
of
Egypt
(A.
annua,
A.
herba-alba,
monosperma
judaica)
their
authentication
is
great
interest.
An
integrated
approach
GC-MS,
HPTLC-image
analysis
near-infrared
(NIR)
spectroscopy
was
implemented
for
fingerprinting,
discrimination
authentication.
GC-MS
revealed
the
phytochemical
profile
volatile
oils
identifying
compounds
spanning
monoterpenes,
sesquiterpenes,
diterpenes
non-terpenoid
compounds.
The
major
chemical
components
were
highlighted
as
camphor,
β-caryophyllene
germacrene
D
camphene,
cis-pinocarveol,
trans-chrysanthenyl
acetate
cis-chrysanthenyl
α-pinene,
β-pinene,
α-terpinolene
(-)-spathulenol
monosperma,
finally,
piperitone
trans-ethyl
cinnamate
judaica.
allowed
tracking
markers
total
alcoholic
extracts.
Artemisinin
detected
only
annua
while
scopoletin
identified
characteristic
coumarin
species.
Phenolic
acids
flavonoids
also
discovered
different
Finally,
NIR
powders
revealing
prominent
spectral
characteristics
correlated
to
by
HPTLC.
Then,
multivariate
facilitated
classification
Additionally,
PLS
regression
utilized
quality
control
powdered
being
an
important
industrial
crop,
detecting
its
adulteration
other
limits
detection
less
than
1.5%.
This
combined
aided
rapid
mean
fingerprinting
Current Topics in Medicinal Chemistry,
Год журнала:
2023,
Номер
24(4), С. 301 - 342
Опубликована: Сен. 15, 2023
Abstract:
Biologically
active
secondary
metabolites,
essential
oils,
and
volatile
compounds
derived
from
medicinal
aromatic
plants
play
a
crucial
role
in
promoting
human
health.
Within
the
large
family
Asteraceae,
genus
Artemisia
consists
of
approximately
500
species.
species
have
rich
history
traditional
medicine
worldwide,
offering
remedies
for
wide
range
ailments,
such
as
malaria,
jaundice,
toothache,
gastrointestinal
problems,
wounds,
inflammatory
diseases,
diarrhoea,
menstrual
pains,
skin
disorders,
headache,
intestinal
parasites.
The
therapeutic
potential
is
multitude
phytoconstituents,
including
terpenoids,
phenols,
flavonoids,
coumarins,
sesquiterpene
lactones,
lignans,
alkaloids
that
serve
pharmaceutical
ingredients
(API).
remarkable
antimalarial,
antimicrobial,
anthelmintic,
antidiabetic,
anti-inflammatory,
anticancer,
antispasmodic,
antioxidative
insecticidal
properties
possessed
by
are
attributed
to
these
APIs.
Interestingly,
several
commercially
utilized
drugs,
arglabin,
artemisinin,
artemether,
artesunate,
santonin,
tarralin
also
been
different
However,
despite
vast
potential,
only
limited
number
exploited
commercially.
Further,
available
literature
on
pharmacological
uses
lacks
comprehensive
reviews.
Therefore,
there
an
urgent
need
bridge
existing
knowledge
gaps
provide
scientific
foundation
future
research
endeavours.
It
this
context,
present
review
aims
account
uses,
phytochemistry,
documented
biological
toxicity
all
offers
useful
insights
practitioners
researchers
into
underutilized
their
applications.
This
stimulate
further
exploration,
experimentation
collaboration
fully
realize
augmenting
health
well-being.
Biomedical and Biotechnology Research Journal (BBRJ),
Год журнала:
2024,
Номер
8(1), С. 37 - 44
Опубликована: Янв. 1, 2024
Background:
Artemisia
deserti
Krasch
belongs
to
Asteraceae
family,
and
has
many
medicinal
properties
that
used
treat
a
variety
of
diseases,
including
antihypertensive,
invigorating
blood
circulation,
antiallergy,
antiviral,
antitumor,
antioxidant.
Methods:
The
objective
this
study
was
the
evaluation
cytotoxic
antioxidant
activities
as
well
chemical
composition
A.
essential
oil
extracted
by
different
extraction
methods.
These
methods
included
hydro-distillation
(HD),
salt-HD
(Salt
pretreatment
followed
HD),
maceration-HD
(maceration
acid-HD
(acid
ultrasound-HD
(ultrasound
enzyme-HD
(enzyme
HD).
Results:
results
revealed
highest
yield
achieved
(0.48%
±
0.11%).
In
all
methods,
main
compounds
were
camphor
(44.32%–66.80%),
piperiton
(14.11%–24.33%),
1,8-cineole
(4.85%–6.75%).
property
oils
investigated
using
DPPH
method.
Based
on
results,
had
property.
evaluated.
demonstrated
indicated
cytotoxicity
activity
against
human
cervical
carcinoma
(HeLa)
cells
in
both
24
48
h.
gas
chromatography-mass
spectrometry
1,8-cineol,
carvacrol,
thymol,
myristicin
rich
enzyme-HD,
obtained
method
is
probably
related
these
compounds.
Conclusion:
addition,
it
observed
an
effective
with
activities.
