Infection Prevention in Practice, Год журнала: 2023, Номер 5(4), С. 100317 - 100317
Опубликована: Ноя. 14, 2023
Язык: Английский
Nature Medicine, Год журнала: 2024, Номер 30(9), С. 2432 - 2443
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
16
Current Opinion in Pediatrics, Год журнала: 2025, Номер 37(2), С. 116 - 123
Опубликована: Янв. 30, 2025
The densely populated Asia Pacific region is home to 600 million children, and suffers from a significant burden of morbidity mortality due infections associated with antimicrobial resistance (AMR). We aimed identify the drivers, challenges potential opportunities alter AMR within region. Despite high borne by region, there are limited (and geographically imbalanced) published data delineate contemporary epidemiology serious multidrug-resistant bacterial in children. Furthermore, impacted overcrowded poorly resourced healthcare facilities, insufficient microbiological resources, widespread community environmental antibiotic use leading efficacy for frequently prescribed antibiotics. Vaccine coverage also inadequate inequitable, further driving infectious disease overuse) There many implementing stewardship infection prevention control programs reduce excessive children across yet locally-driven strategies have successfully reduced overuse some settings, should be replicated. Reducing will require improved resourcing, including better access diagnosis, multidisciplinary approaches enhance prescribing.
Язык: Английский
Процитировано
1
Infection and Drug Resistance, Год журнала: 2024, Номер Volume 17, С. 641 - 653
Опубликована: Фев. 1, 2024
Purpose: We determined the phenotypic resistance to third-generation cephalosporins, extended spectrum beta-lactamase (ESBL) prevalence, and genotypic prevalence of ESBL-encoding genes blaCTX-M, blaTEM, blaSHV in Enterobacteriaceae isolated from hematologic cancer patients with febrile neutropenia bacteremia at Uganda Cancer Institute (UCI). Patients Methods: Blood cultures were processed BACTEC 9120. E. coli, K. pneumoniae, Enterobacter spp . isolates identified using conventional biochemical methods. Antimicrobial susceptibility tests, ESBL characterization, characterization blaTEM , for pure Results: Two hundred two included study. Median age was 19 years (IQR: 10– 30 years). Majority (N=119, 59%) male patients. Sixty (30%) participants had least one episode due Enterobacteriaceae. Eighty-three organisms coli being predominant (45, 54%). Seventy-nine (95%) multidrug resistant. The phenotype detected 54/73 (74%) that resistant cephalosporins. A higher proportion ESBL-positive piperacillin-tazobactam (p=0.024), gentamicin (p=0.000), ciprofloxacin cotrimoxazole (p=0.000) compared Enterobacteriaceae, which sensitive more susceptible carbapenems chloramphenicol than ( ) 55 (75%) 73 BlaCTX-M most common gene 50 (91%). Conclusion: ESBL-producing are a cause UCI. ESBL-PE blaCTX-M Resistance imipenem meropenem low. Keywords: antimicrobial resistance, beta-lactamases, enterobacteriaceae, CTX-M, Uganda,
Язык: Английский
Процитировано
9
Microorganisms, Год журнала: 2024, Номер 12(8), С. 1697 - 1697
Опубликована: Авг. 17, 2024
Antimicrobial resistance (AMR) is a public health problem exacerbated by the overuse and misuse of antibiotics inadequate capacity laboratories to conduct AMR surveillance. This study assessed in seven faith-based hospitals testing surveillance Zambia. multi-facility, cross-sectional exploratory was conducted from February 2024 April 2024. We collected analysed data using self-scoring Laboratory Assessment Antibiotic Resistance Testing Capacity (LAARC) tool. found an average score 39%, indicating low The highest 47%, while lowest 25%. Only one hospital had full (100%) utilise laboratory information system (LIS). Three satisfactory perform management with scores 83%, 85%, 95%. process specimens, only good safety requirements for microbiology laboratory, 89%. demonstrates that all surveillance, which could affect diagnostic stewardship. Therefore, there urgent need strengthen enhance
Язык: Английский
Процитировано
6
Frontiers in Public Health, Год журнала: 2024, Номер 12
Опубликована: Сен. 27, 2024
Background Antimicrobial stewardship (AMS) programs are critical in combating antimicrobial resistance (AMR). In Zambia, there is little information regarding the capacity of hospitals to establish and implement AMS programs. The objective this study was conduct a baseline assessment WHO core elements for an program implementation eight Zambia. Materials methods We conducted exploratory cross-sectional from September 2023 December using self-scoring Periodic National Healthcare Facility Assessment Tool World Health Organization (WHO) policy guidance on integrated activities human health. Eight public were surveyed across five provinces Data analyzed tool thematic analysis. Results Overall, 62.5% (6/8) facilities scored low (below 60%) implementing Most had challenges with reporting feedback within hospital (average score = 46%), Drugs Therapeutics Committee (DTC) functionality 49%), actions 50%), education training 54%), leadership commitment 56%). overall all average (56%). All (100%) did not have allocated budget Finally, neither antibiograms guide utilization nor AMS-trained staff more than 50% surveyed. Conclusion This found these hospitals, especially where DTCs non-functional. identified gaps require urgent attention sustainable multidisciplinary
Язык: Английский
Процитировано
6
Heliyon, Год журнала: 2024, Номер 10(11), С. e32663 - e32663
Опубликована: Июнь 1, 2024
BackgroundIndiscriminate use of antibiotics leads to antibiotic resistance (AMR) and results in mortality, morbidity, financial burden. Antibiotic stewardship programs (ASPs) with education can resolve a number barriers recognized the implementation successful ASPs. The aim this study was assess health professionals' perceptions status ASPs hospitals 2022.MethodsA cross-sectional conducted from September 1, 2022 October 30, 2022. A total 181 professionals were included, self-administered questionnaire used collect data. assessed using checklist. data analyzed SPSS version 23, descriptive statistics Chi-square tests (X2) at P-value <0.05 used.ResultsOf respondents, 163 (90.1 %), 161 (89.0 %) believed that AMR is significant problem Ethiopia globally, respectively. Easy access 155 (85.6 inappropriate 137 (75.7 perceived as key contributors AMR. Antibiotics be prescribed/dispensed without laboratory 86 (47.5 susceptibility patterns not considered guide empiric therapy 81 (44.8 %). ASP reduce duration hospital stays associated costs improve quality patient care 133 (73.5 whereas 151 (83.4 143 (79 142 (78.5 suggested education, institutional guidelines, prospective audits feedback interventions combat their hospitals, There differences perception among based on professional category attempts by implement Although functioning according standard, there have been it three hospitals. issue had never heard general Currently, feasible four hospitals.ConclusionThe very poor. Despite lack prior knowledge ASPs, most respondents do positive Pharmacist-led guidelines for better implemented Involvement representatives infection prevention control, collaboration will help establish strong area.
Язык: Английский
Процитировано
4
BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)
Опубликована: Апрель 26, 2024
Overuse of antibiotics is a key driver antimicrobial resistance (AMR) world-wide. Malawi continues to report rising cases AMR among both in-patients and out-patients. We investigated antibiotic use patterns patients with suspected first line treatment failure at Rumphi District Hospital, Malawi.
Язык: Английский
Процитировано
3
Antimicrobial Resistance and Infection Control, Год журнала: 2024, Номер 13(1)
Опубликована: Июль 4, 2024
Abstract The use of antimicrobials in Thailand has been reported as one the highest world human and animal sectors. Our engagement project aimed to improve our understanding issue antimicrobial resistance (AMR) among adult Thai communities, co-create locally relevant solutions AMR, especially those focusing on raising awareness related policies Thailand. We conducted a series online in-person ‘conversations’ according Wellcome’s ‘Responsive Dialogues’ approach, designed bring together different voices understand complex AMR problems find potential solutions. This approach enabled key stakeholders policy makers hear directly from communities members public, vice versa. Conversations events took place between 25 November 2020 8 July 2022, we engaged 179 public across issues found were: there were quite lot misunderstandings around AMR; participants felt that communications had limited reach impact; asking for taking antibiotics self-limiting ailments is social norm Thailand; appeared be wide availability cheap antimicrobials. To mitigate spread suggested messages should tailored target audience, more initiatives increase general health literacy, increased information at local level leadership mitigation efforts. Trial registration Thaiclinicaltrials.org registration: TCTR20210528003 (28/05/2021).
Язык: Английский
Процитировано
3
The Science of The Total Environment, Год журнала: 2024, Номер 956, С. 177367 - 177367
Опубликована: Ноя. 8, 2024
The rise of antimicrobial resistance (AMR) remains a pressing global health challenge. Infections that were once easily treatable with first-line antimicrobials are becoming increasingly difficult to manage. This shift directly threatens the wellness humans, animals, plants, and environment. While AMR crisis can be attributed myriad factors, including lack infection prevention control measures, over-prescription antimicrobials, patient non-compliance, misuse one aspect has garnered less attention is role storage conditions these medicines. way medications, particularly transported stored until point use influence their efficacy and, subsequently, may impact development resistant microbial strains. review delves deeper into often-overlooked domain climate change (CC) practices potential effects. Inappropriate conditions, such as exposure extreme temperatures, humidity or light, degrade potency antimicrobials. When compromised medicines administered patients animals alike, they not effectively eradicate targeted pathogens, leading partial survival pathogens. These surviving having been exposed sub-lethal doses, more likely evolve develop mechanisms. discusses mechanism underlying this underscores implications in relation two most challenges: CC. also presents specific case studies highlights importance monitoring supply chain surveillance. Furthermore, deploying genomic tools understand on discussed, highlighted crucial part comprehensive strategies fight against AMR.
Язык: Английский
Процитировано
3
Antibiotics, Год журнала: 2025, Номер 14(3), С. 266 - 266
Опубликована: Март 5, 2025
Background: Antimicrobial stewardship (AMS) programs optimize the use of antimicrobials and reduce antimicrobial resistance (AMR). This study evaluated implementation AMS in Africa using a harmonized regional approach. Methods: was an exploratory cross-sectional across five countries involving 32 hospitals adapted Periodic National Hospitals Assessment Tool from World Health Organization (WHO) policy guidance on integrated activities human health. Results: found baseline scores for core elements ranging 34% to 79% at which improved 58% 92% endline. At baseline, Drugs Therapeutics Committee (DTC) functionality updating facility-specific medicines medical devices ranged 100%, this 79 100% Classifying antibiotics by WHO AWaRe, classification 33% 83% 64% Leadership commitment were 47% 66% Education training 42% 63% endline, respectively. Reporting feedback Conclusions: Our showed that understanding context standardizing approaches enhanced cross-country learning implementation. Although challenges Low- Middle-Income Countries (LMICs) are similar, they vary country can be addressed strengthening regulatory frameworks surveillance systems.
Язык: Английский
Процитировано
0