FOXP3 (in)stability and cancer immunotherapy

Cytokine, Год журнала: 2024, Номер 178, С. 156589 - 156589

Опубликована: Март 27, 2024

Язык: Английский

---

Influence of Microbiota on Tumor Immunotherapy

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(6), С. 2264 - 2294

Опубликована: Янв. 1, 2024

The role of the microbiome in immunotherapy has recently garnered substantial attention, with molecular studies and clinical trials providing emerging evidence on pivotal influence microbiota enhancing therapeutic outcomes via immune response modulation.However, impact microbial communities can considerably vary across individuals different immunotherapeutic approaches, posing prominent challenges harnessing their potential.In this comprehensive review, we outline current research applications tumor delve into possible mechanisms through which function is influenced by various body sites, encompassing those gut, extraintestinal barrier, intratumoral environment.Furthermore, discuss effects diverse microbiome-based strategies, including probiotics, prebiotics, fecal transplantation, targeted modulation specific taxa, antibiotic treatments cancer immunotherapy.All these strategies potentially have a profound pave way for personalized approaches predictive biomarkers.

Язык: Английский

---

Circulating cytokines associated with clinical outcomes in advanced non‐small cell lung cancer patients who received chemoimmunotherapy

Thoracic Cancer, Год журнала: 2021, Номер 13(2), С. 219 - 227

Опубликована: Ноя. 25, 2021

Abstract Background Pretreatment and on‐treatment plasma cytokine levels in predicting clinical benefit patients with advanced non‐small cell lung cancer (NSCLC) treated anti‐programmed death‐1 (PD‐1)‐based chemotherapy is still a matter of debate. Methods We measured 12 kind cytokines stage III/IV NSCLC before during treatment anti‐PD‐1 based chemotherapy. Associations best overall response, survival including progression‐free (PFS) (OS) were assessed using Chi‐square test Kaplan–Meier plots log‐rank test, respectively. Logistic regression Cox used to determine independent risk factors. Results Of total 60 patients, high‐level pretreatment interleukin‐2 was associated longer PFS (log rank p = 0.049), while interleukin‐8 shorter OS 0.006). Increased interleukin‐1β (IL‐1β) both better response (odds ratio [OR] 6.233, 95% confidential interval [CI]: 1.451–26.344, 0.013) (hazard [HR] 0.305, CI: 0.127–0.730, 0.008). On the contrary, increased interleukin‐6 (IL‐6) worse (OR 0.015, 0.001–0.400, 0.012), (HR 2.639, 1.163–5.991, 0.020) 2.742, 1.063–7.074, 0.037). interferon‐γ (IFN‐γ) found be 0.336, 0.153–0.745, 0.007). Conclusions In who received chemoimmunotherapy, IL‐1β IFN‐γ may serve as positive indicator efficacy, IL‐6 might play predictive role outcome.

Язык: Английский

---

Polypharmacological Cell-Penetrating Peptides from Venomous Marine Animals Based on Immunomodulating, Antimicrobial, and Anticancer Properties

Marine Drugs, Год журнала: 2022, Номер 20(12), С. 763 - 763

Опубликована: Дек. 4, 2022

Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be targeted by multipronged curative. Various omics technologies, with a high rate of data generation, demand artificial intelligence translate these into druggable targets. In this study, 82 marine venomous animal species were retrieved, 3505 cryptic cell-penetrating peptides (CPPs) identified in their toxins. A total 279 safe further analyzed for antimicrobial, anticancer, immunomodulatory characteristics. Protease-resistant CPPs endosomal-escape ability Hydrophis hardwickii, nuclear-localizing Scorpaena plumieri, mitochondrial-targeting from Synanceia horrida suitable compartmental drug delivery. broad-spectrum S. horrida-derived antimicrobial peptide binding-affinity bacterial membranes was an antigen-presenting cell (APC) stimulator that primes cytokine release naïve T-cell maturation simultaneously. While antibiofilm wound-healing detected verrucosa, APC epitopes universal adjuvants antiviral vaccination Pterois volitans Conus monile. pennaceus-derived anticancer showed antiangiogenic IL-2-inducing properties moderate BBB-permeation defined tumor-homing (THP) the inhibit programmed death ligand-1 (PDL-1). Isoforms RGD-containing innate characteristics tessulatus tumor targeting. Inhibitors neuropilin-1 C. pennaceus are proposed imaging probes or therapeutic betulinus peptide, BBB-permeation, mitochondrial-targeting, antioxidant capacity, anti-inflammatory cytokines non-inducer proinflammation Alzheimer's. Conclusively, we have considered dynamic interaction cells, microenvironment, proportional-orchestrating-host- immune pathways multi-target-directed resembling single-molecule polypharmacology. This strategy might fill gap complex resistant disorders increase candidates' clinical-translation chance.

Язык: Английский

---

NK and cells with NK-like activities in cancer immunotherapy-clinical perspectives

Medical Oncology, Год журнала: 2022, Номер 39(9)

Опубликована: Июнь 18, 2022

Язык: Английский

---