Arhiv za farmaciju,
Год журнала:
2024,
Номер
74(6), С. 774 - 795
Опубликована: Янв. 1, 2024
Schizophrenia
and
other
related
disorders
represent
a
major
clinical
challenge,
with
environmental
genetic
factors
contributing
to
their
occurrence.
Animal
models
are
indispensable
tools
for
understanding
the
complex
neurobiological
mechanisms
underlying
psychosis
developing
new
therapeutic
approaches.
This
review
focuses
on
animal
commonly
used
in
schizophrenia
research,
especially
those
based
prenatal
postnatal
risk
factors.
Prenatal
exposure
infections,
such
as
bacterial
lipopolysaccharides
(LPS)
viral
components
poly
I:C,
activates
immune
responses
that
lead
long-lasting
structural
functional
changes
brain,
including
hippocampal
atrophy
cortical
thinning.
Postnatal
early
life
stress,
social
isolation
drug
abuse,
particularly
cannabis,
also
being
modelled
investigate
effects
brain
development
onset
of
psychosis.
These
allow
controlled
manipulation
challenges
provide
insights
into
aetiology
pathophysiology
disease.
However,
variability
experimental
protocols
lack
female
representation
many
studies
underscore
need
more
robust
inclusive
models.
Ultimately,
these
crucial
better
testing
potential
interventions.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 11, 2023
Currently,
the
recovery
of
cognitive
function
has
become
an
essential
part
stroke
rehabilitation.
DL-3-n-butylphthalide
(NBP)
is
a
neuroprotective
reagent
and
been
used
in
treatment.
Clinical
studies
have
confirmed
that
NBP
can
achieve
better
outcomes
ischemic
patients
than
healthy
controls.
In
this
study,
we
aimed
to
investigate
influences
on
reperfusion
(I/R)
rat
model.
Our
results
showed
profoundly
decreased
neurological
scores,
reduced
cerebral
infarct
areas
enhanced
blood
flow
(CBF).
potently
alleviated
poststroke
impairment
(PSCI)
including
depression-like
behavior
learning,
memory
social
cognition
impairments,
I/R
rats.
distinctly
suppressed
activation
microglia
astrocytes
improved
neuron
viability
brain.
inhibited
expression
inflammatory
cytokines,
interleukin-6
(IL-6),
interleukin-1β
(IL-1β)
tumor
necrosis
factor-α
(TNF-α),
by
targeting
nuclear
factor
kappa
B/inducible
nitric
oxide
synthase
(NF-κB/iNOS)
pathway
oxidative
stress
factors,
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
kelch
like
ECH
associated
protein
1/nuclear
factor-erythroid
2
p45-related
(Keap1/Nrf2)
The
current
study
revealed
treatment
ameliorated
rats,
possibly
synergistically
suppressing
inflammation
stress.
International Journal of Intelligent Systems,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
We
investigated
the
fusion
of
Intelligent
Internet
Medical
Things
(IIoMT)
with
depression
management,
aiming
to
autonomously
identify,
monitor,
and
offer
accurate
advice
without
direct
professional
intervention.
Addressing
pivotal
questions
regarding
IIoMT’s
role
in
identification,
its
correlation
stress
anxiety,
impact
machine
learning
(ML)
deep
(DL)
on
depressive
disorders,
challenges
potential
prospects
integrating
management
IIoMT,
this
research
offers
significant
contributions.
It
integrates
artificial
intelligence
(AI)
(IoT)
paradigms
expand
studies,
highlighting
data
science
modeling’s
practical
application
for
intelligent
service
delivery
real‐world
settings,
emphasizing
benefits
within
IoT.
Furthermore,
it
outlines
an
IIoMT
architecture
gathering,
analyzing,
preempting
employing
advanced
analytics
enhance
intelligence.
The
study
also
identifies
current
challenges,
future
trajectories,
solutions
domain,
contributing
scientific
understanding
management.
evaluates
168
closely
related
articles
from
various
databases,
including
Web
Science
(WoS)
Google
Scholar,
after
rejection
repeated
books.
shows
that
there
is
48%
growth
articles,
mainly
focusing
symptoms,
detection,
classification.
Similarly,
most
being
conducted
United
States
America,
trend
increasing
other
countries
around
globe.
These
results
suggest
essence
automated
monitoring,
suggestions
handling
depression.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 29, 2025
Neurodegenerative
diseases,
characterized
by
progressive
neuronal
loss
and
cognitive
impairments,
pose
a
significant
global
health
challenge.
This
study
explores
the
potential
of
nanotherapeutics
as
promising
approach
to
enhance
drug
delivery
across
physiological
barriers,
particularly
blood–brain
barrier
(BBB)
blood-cerebrospinal
fluid
(B-CSFB).
By
employing
nanoparticles,
this
research
aims
address
critical
challenges
in
diagnosis
treatment
conditions
such
Alzheimer’s,
Parkinson’s,
Huntington’s
diseases.
The
multifactorial
nature
these
disorders
necessitates
innovative
solutions
that
leverage
nanomedicine
improve
solubility,
circulation
time,
targeted
while
minimizing
off-target
effects.
findings
underscore
importance
advancing
applications
develop
effective
therapeutic
strategies
can
alleviate
burden
neurodegenerative
diseases
on
individuals
healthcare
systems.
BMC Health Services Research,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 20, 2025
Postpartum
depression
(PPD)
poses
significant
risks
to
both
maternal
and
child
health,
yet
it
remains
underdiagnosed
undertreated,
particularly
in
developing
countries
like
Bangladesh.
Factors
such
as
hormonal
changes,
lack
of
communal
support
socioeconomic
stressors
primarily
contribute
its
prevalence.
Despite
advancements
research,
technological
solutions
for
PPD
are
lacking
regions
where
mental
health
is
deemed
negligible.
Thus,
the
objectives
this
research
reveal
underlying
factors
contributing
among
mothers
propose
a
novel
application
based
on
these
detection.
A
Design
Science
Research
(DSR)
approach
adopted
achieve
objectives.
In
firstly
17
that
could
serve
effective
indicators
detecting
were
identified
through
interviews
with
12
key
informants,
including
doctors
patients.
Next,
each
factor,
visual
scenario-based
questionnaires
designed
facilitate
screening
user
feedback.
Then,
an
Android
application,
'PPD
Screening
App',
was
developed,
which
provides
users
visual,
auditory,
multilingual
(in
English
Bengali)
well
proposed
Edinburgh
Postnatal
Depression
Scale
(EPDS)
Finally,
developed
evaluated
45
new
postpartum
period
demonstrated
high
accuracy
(96%)
compared
traditional
method
(84%).
The
effectiveness
also
explored
relation
participants'
demographic
profiles
(age
IT
literacy),
participants
provided
very
positive
feedback
usability
application.
This
thus
contributes
improving
early
detection
intervention
PPD,
ultimately
enhancing
well-being.
