Understanding schizophrenia through animal models: The role of environmental stressors DOI Creative Commons
M. Manojlović

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(6), P. 774 - 795

Published: Jan. 1, 2024

Schizophrenia and other related disorders represent a major clinical challenge, with environmental genetic factors contributing to their occurrence. Animal models are indispensable tools for understanding the complex neurobiological mechanisms underlying psychosis developing new therapeutic approaches. This review focuses on animal commonly used in schizophrenia research, especially those based prenatal postnatal risk factors. Prenatal exposure infections, such as bacterial lipopolysaccharides (LPS) viral components poly I:C, activates immune responses that lead long-lasting structural functional changes brain, including hippocampal atrophy cortical thinning. Postnatal early life stress, social isolation drug abuse, particularly cannabis, also being modelled investigate effects brain development onset of psychosis. These allow controlled manipulation challenges provide insights into aetiology pathophysiology disease. However, variability experimental protocols lack female representation many studies underscore need more robust inclusive models. Ultimately, these crucial better testing potential interventions.

Language: Английский

Inorganic Nanoparticles and Blood-Brain Barrier Modulation: Advancing Targeted Neurological Therapies DOI
Zahra Razavi, F. S. Razavi,

Seyed Sina Alizadeh

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357

Published: Feb. 5, 2025

Language: Английский

Citations

5
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress DOI Creative Commons
Hui Zhang,

Laifa Wang,

Yongping Yang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 11, 2023

Currently, the recovery of cognitive function has become an essential part stroke rehabilitation. DL-3-n-butylphthalide (NBP) is a neuroprotective reagent and been used in treatment. Clinical studies have confirmed that NBP can achieve better outcomes ischemic patients than healthy controls. In this study, we aimed to investigate influences on reperfusion (I/R) rat model. Our results showed profoundly decreased neurological scores, reduced cerebral infarct areas enhanced blood flow (CBF). potently alleviated poststroke impairment (PSCI) including depression-like behavior learning, memory social cognition impairments, I/R rats. distinctly suppressed activation microglia astrocytes improved neuron viability brain. inhibited expression inflammatory cytokines, interleukin-6 (IL-6), interleukin-1β (IL-1β) tumor necrosis factor-α (TNF-α), by targeting nuclear factor kappa B/inducible nitric oxide synthase (NF-κB/iNOS) pathway oxidative stress factors, reactive oxygen species (ROS) malondialdehyde (MDA), kelch like ECH associated protein 1/nuclear factor-erythroid 2 p45-related (Keap1/Nrf2) The current study revealed treatment ameliorated rats, possibly synergistically suppressing inflammation stress.

Language: Английский

Citations

39
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats DOI
Hui Zhang,

Laifa Wang,

Bi Zhu

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 951, P. 175801 - 175801

Published: May 18, 2023

Language: Английский

Citations

25
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Intelligent Internet of Medical Things for Depression: Current Advancements, Challenges, and Trends DOI Creative Commons
Md Belal Bin Heyat, Deepak Adhikari, Faijan Akhtar

et al.

International Journal of Intelligent Systems, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

We investigated the fusion of Intelligent Internet Medical Things (IIoMT) with depression management, aiming to autonomously identify, monitor, and offer accurate advice without direct professional intervention. Addressing pivotal questions regarding IIoMT’s role in identification, its correlation stress anxiety, impact machine learning (ML) deep (DL) on depressive disorders, challenges potential prospects integrating management IIoMT, this research offers significant contributions. It integrates artificial intelligence (AI) (IoT) paradigms expand studies, highlighting data science modeling’s practical application for intelligent service delivery real‐world settings, emphasizing benefits within IoT. Furthermore, it outlines an IIoMT architecture gathering, analyzing, preempting employing advanced analytics enhance intelligence. The study also identifies current challenges, future trajectories, solutions domain, contributing scientific understanding management. evaluates 168 closely related articles from various databases, including Web Science (WoS) Google Scholar, after rejection repeated books. shows that there is 48% growth articles, mainly focusing symptoms, detection, classification. Similarly, most being conducted United States America, trend increasing other countries around globe. These results suggest essence automated monitoring, suggestions handling depression.

Language: Английский

Citations

1
Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction DOI

Guang-Jing Zou,

Chen Zhaorong,

Xueqin Wang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 978, P. 176759 - 176759

Published: June 18, 2024

Language: Английский

Citations

4
Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology DOI Creative Commons

Rupal Dhariwal,

Mukul Jain, Y. Mir

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Language: Английский

Citations

0
Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders DOI

Dhanshree Nibrad,

Amit Shiwal,

Manasi Tadas

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Auramine O, food dye induces cognitive impairment, anxiety, alters synaptic transmission and neural growth in zebrafish model DOI

Karthikeyan Ramamurthy,

Santhanam Sanjai Dharshan,

Ashok Kumar

et al.

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Identifying key indicators to develop a novel mobile application for early screening of postpartum depression in developing countries DOI Creative Commons
Sumaiya Nuha Mustafina, Muhammad Nazrul Islam,

Mohammad Ratul Mahjabin

et al.

BMC Health Services Research, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 20, 2025

Postpartum depression (PPD) poses significant risks to both maternal and child health, yet it remains underdiagnosed undertreated, particularly in developing countries like Bangladesh. Factors such as hormonal changes, lack of communal support socioeconomic stressors primarily contribute its prevalence. Despite advancements research, technological solutions for PPD are lacking regions where mental health is deemed negligible. Thus, the objectives this research reveal underlying factors contributing among mothers propose a novel application based on these detection. A Design Science Research (DSR) approach adopted achieve objectives. In firstly 17 that could serve effective indicators detecting were identified through interviews with 12 key informants, including doctors patients. Next, each factor, visual scenario-based questionnaires designed facilitate screening user feedback. Then, an Android application, 'PPD Screening App', was developed, which provides users visual, auditory, multilingual (in English Bengali) well proposed Edinburgh Postnatal Depression Scale (EPDS) Finally, developed evaluated 45 new postpartum period demonstrated high accuracy (96%) compared traditional method (84%). The effectiveness also explored relation participants' demographic profiles (age IT literacy), participants provided very positive feedback usability application. This thus contributes improving early detection intervention PPD, ultimately enhancing well-being.

Language: Английский

Citations

0