Antivirals and Biologics for Broader Coverage Against Human Coronaviruses DOI Open Access

Mia Outteridge,

Christine M. Nunn,

Kevin M. Devine

и другие.

Опубликована: Дек. 12, 2023

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome 27-31kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and 9 accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles replication cycle immune evasion (1). There 7 known human CoVs most likely appeared after zoonotic transfer, recent being SARS-CoV-2 responsible Covid-19 pandemic. Antivirals been approved by FDA use against such as Paxlovid can potentially target successfully inhibit main protease (MPro) activity of CoVs, however alternative proteomes encoded CoV genomes closer genetic similarity to each other, suggesting antivirals could be developed now future CoVs. New introductions humans inevitable unpredictable. Therefore, new required control not only next outbreak, but also 4 common (229E, OC43, NL63, HKU1) circulate frequently contain sporadic outbreaks severe (SARS-CoV, MERS SARS-CoV-2). The current study found emerging antiviral drugs, Paxlovid, proven SARS-CoV-2. Other drugs which potential other still within clinical trial yet available public use. Monoclonal antibody (mAb) treatment vaccines reduce mortality hospitalisation rates, they Spike protein whose sequence mutates drifts. is applicable targeting HCoVs these well conserved sequences among Thus, there need readily treatments globally all improve preparedness outbreaks. Here we discuss research contributing transmission, including outbreak. aim was identify features antivirals, biologics scientific, political, economic health strain caused future.

Язык: Английский

Animal Trypanosomiasis: Challenges and Prospects for New Vaccination Strategies DOI Creative Commons
Samille Henriques Pereira,

Felipe Giordano Matos Menezes Alves,

Santuza Maria Ribeiro Teixeira

и другие.

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2575 - 2575

Опубликована: Дек. 13, 2024

Animal trypanosomiasis, such as nagana, surra, and dourine, represent a significant challenge to animal health economic development, especially in tropical subtropical regions where livestock production is an essential component of country’s economy. Despite advances the control human diseases caused by several species trypanosomes remain neglected. The lack funding for development new treatments vaccines contributes sustaining severe impacts these have on farming industry, low-income rural areas. Recent understanding immune processes involved during infection been approaches towards disease including vaccines. These must be part integrated programs, which also include vector management awareness good veterinary practices. Addressing challenges posed trypanosomiasis requires collaborative continuous efforts shared among scientists, governments, if progress made mitigate impact diseases. In this literature review, we discuss main research underway, prospects employing vaccine platforms, mRNA vaccine, vector-based CRISPR-attenuated parasite vaccine.

Язык: Английский

Процитировано

1
Comparing the Efficacy and Adverse Events of Available COVID-19 Vaccines Through Randomized Controlled Trials: Updated Systematic Review and Network Meta-analysis DOI Open Access
Shima Hossaini, Fariba Keramat, Zahra Cheraghi

и другие.

Journal of Research in Health Sciences, Год журнала: 2023, Номер 23(4), С. e00593 - e00593

Опубликована: Дек. 29, 2023

Background: Different vaccines have so far been developed and approved to cope with COVID-19 in the world. The aim of this updated network meta-analysis (NMA) was compare rank all available terms efficacy complications simultaneously. Study Design: A systematic review. Methods: Three major international databases, including Web Science, Medline via PubMed, Scopus, were searched through September 2023. transitivity assumption evaluated qualitatively epidemiologic effect modifiers. exposure interest study receiving any vaccine, primary outcome incidence symptomatic COVID-19. In NMA, relative risk used summarize preventing data analyzed using frequentist-based approach, results reported a random-effects model. Finally, ranked P-score. Results: total, 34 randomized controlled trials (RCTs) met eligibility criteria for review NMA out 3682 retrieved references. Based on mRNA-1273 most effective vaccine demonstrated highest P-score (0.93). (RR) versus placebo 0.07 (95% confidence interval [CI]: 0.03, 0.17). second third-ranked BNT-162b2 (RR=0.08; 95% CI: 0.04, 0.15; P-score=0.93) Gam-COVID-Vac (0.09; 0.25; 0.88). Conclusion: it seems that prevention. However, top three mRNA-1273, BNT-162b2, Gam-COVID-Vac, respectively.

Язык: Английский

Процитировано

3
mRNA vaccines in gastric cancer: How close are we? DOI
José Darío Portillo‐Miño,

David Bettin-Gonzalez,

Franco Andrés Montenegro Coral

и другие.

Vacunas, Год журнала: 2023, Номер 25(1), С. 88 - 96

Опубликована: Ноя. 22, 2023

Процитировано

2
Myocardial Infarction Following Vaccination Against COVID-19: A Systematic Review DOI Open Access
Nima Rahimi Petrudi, Mostafa Abdollahi, Iraj Mirzaii‐Dizgah

и другие.

Annals of Military and Health Sciences Research, Год журнала: 2023, Номер 21(3)

Опубликована: Окт. 25, 2023

Context: Several reports have been presented regarding the occurrence of acute myocardial infarction following vaccination against COVID-19. Objectives: The current systemic review tried to and summarize published evidence documents various types anti-COVID-19 vaccines (AstraZeneca Pfizer) and, finally, take steps clarify causes such incidents. Methods: relevant databases, including Medline, Web Knowledge, Google Scholar, Scopus, Cochrane, were comprehensively searched by two blinded researchers for all eligible studies based on considered keywords. Of 76 articles initially collected database searching, 20 included in last analysis. Results: was mostly related SARS-CoV-2-based messenger RNA viral vector vaccines. This cardiac attack occurred after first 74% patients affected. time also very different between varied 15 minutes 21 days vaccination. Most infarctions that ST-segment elevation type (STEMI) (23 28 patients). More than two-thirds cases who had significant cardiovascular risk profiles (hypertension, diabetes mellitus, ischemic heart disease). Overall, 22.2% suffering post-vaccination died within hospitalization. Conclusions: COVID-19 is rare, due fatality this event, it necessary modify biotechnological production existing accurately evaluate pathophysiology event.

Язык: Английский

Процитировано

1
Antivirals and Biologics for Broader Coverage Against Human Coronaviruses DOI Open Access

Mia Outteridge,

Christine M. Nunn,

Kevin M. Devine

и другие.

Опубликована: Дек. 12, 2023

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome 27-31kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and 9 accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles replication cycle immune evasion (1). There 7 known human CoVs most likely appeared after zoonotic transfer, recent being SARS-CoV-2 responsible Covid-19 pandemic. Antivirals been approved by FDA use against such as Paxlovid can potentially target successfully inhibit main protease (MPro) activity of CoVs, however alternative proteomes encoded CoV genomes closer genetic similarity to each other, suggesting antivirals could be developed now future CoVs. New introductions humans inevitable unpredictable. Therefore, new required control not only next outbreak, but also 4 common (229E, OC43, NL63, HKU1) circulate frequently contain sporadic outbreaks severe (SARS-CoV, MERS SARS-CoV-2). The current study found emerging antiviral drugs, Paxlovid, proven SARS-CoV-2. Other drugs which potential other still within clinical trial yet available public use. Monoclonal antibody (mAb) treatment vaccines reduce mortality hospitalisation rates, they Spike protein whose sequence mutates drifts. is applicable targeting HCoVs these well conserved sequences among Thus, there need readily treatments globally all improve preparedness outbreaks. Here we discuss research contributing transmission, including outbreak. aim was identify features antivirals, biologics scientific, political, economic health strain caused future.

Язык: Английский

Процитировано

1