COVID-19 Modified mRNA “Vaccines”: Lessons Learned from Clinical Trials, Mass Vaccination, and the Bio-Pharmaceutical Complex, Part 2
International Journal of Vaccine Theory Practice and Research,
Год журнала:
2024,
Номер
3(2), С. 1275 - 1344
Опубликована: Авг. 16, 2024
The
COVID-19
modified
mRNA
(modmRNA)
lipid
nanoparticle-based
“vaccines”
are
not
classical
antigen-based
vaccines
but
instead
prodrugs
informed
by
gene
therapy
technology.
Of
considerable
note,
these
products
have
been
linked
to
atypical
adverse
and
serious
event
profiles.
As
discussed
in
Part
1,
health-related
risks
drawbacks
were
drastically
misreported
underreported
the
Pfizer
Moderna
trial
evaluations
of
genetic
products.
Now
2,
we
examine
main
structural
functional
aspects
injectables.
modmRNA
injectable
introduce
a
unique
set
biological
challenges
human
body
with
potential
induce
an
extensive
range
adverse,
crippling,
life-threatening
effects.
Based
on
fact
that
there
is
no
current
method
quantify
host
(cell-based)
spike
protein
production
vivo
following
injection
prodrugs,
standard
“dose”.
This
part
due
differences
output,
which
depends
cell
metabolism
transfection
efficiency.
It
therefore
difficult
predict
profiles
individual
basis,
considering
millions
adults
across
world
reported
severe
events
context
products,
valid
concerns
raised
regarding
infants
younger
age
groups
for
whom
poses
only
minimal
risks.
We
address
process-related
impurities
inherent
mass
posed
contaminants.
then
categorize
principal
associated
brief
systems-based
synopsis
each
six
domains
harms:
(1)
cardiovascular,
(2)
neurological,
(3)
hematologic;
(4)
immunological,
(5)
oncological,
(6)
reproductive.
conclude
discussion
primary
public
health
regulatory
issues
arising
from
this
evidence-informed
synthesis
literature
reiterate
urgency
imposing
global
moratorium
modmRNA-LNP-based
platform.
Язык: Английский
Investigating Non-Compliance with COVID-19 Vaccination through Hesitancy, Refusal, and Access Limitation: A Community-Based Survey from the Democratic Republic of the Congo
Nestor Kalala-Tshituka,
Alain Cimuanga-Mukanya,
Alain Yamba Mukendi
и другие.
Journal of Biosciences and Medicines,
Год журнала:
2024,
Номер
12(09), С. 280 - 306
Опубликована: Янв. 1, 2024
Язык: Английский
Polyethylene Glycols Stimulate Ca2+ Signaling, Cytokine Production, and the Formation of Neutrophil Extracellular Traps
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13165 - 13181
Опубликована: Дек. 1, 2024
Given
the
increased
use
of
polyethylene
glycol
(PEG)
in
refining
therapeutic
activity
medicines,
our
research
focuses
on
explaining
potential
mechanism
immune
reactions
associated
with
this
polymer.
We
aim
to
investigate
interaction
different
types
PEG
mouse
and
human
cells,
thereby
contributing
understanding
interactions
system
verifying
proinflammatory
tested
polymers.
Язык: Английский