Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 159 - 171
Опубликована: Янв. 1, 2025
Oxidative
stress
is
an
important
cause
of
acetaminophen
(APAP)-induced
liver
injury
(AILI).
Sakuranetin
(Sak)
antitoxin
from
the
cherry
flavonoid
plant
with
good
antioxidant
effects.
However,
whether
sakuranetine
has
a
protective
effect
on
APAP-induced
not
clear.
Mouse
and
HepG2
cell
models
APAP
were
used
to
investigate
sakuranetin
AILI
its
mechanism.
Serum
transaminase
levels,
histological
changes,
inflammatory
mediators,
oxidative
stress,
ferroptosis-related
markers
Nrf2
signaling
pathway
proteins
analyzed.
significantly
reduced
serum
alanine
aminotransferase
(ALT)
aspartate
(AST),
as
well
factor;
increased
activity
decreased
death;
inhibited
ROS
production,
glutathione
(GSH)
content,
expression
Glutathione
Peroxidase
4
(GPX4)
Solute
Carrier
Family
7
Member
11
(SLC7A11),
malondialdehyde
Acyl-CoA
Synthetase
Long
Chain
(ACSL4)
in
mice
cells
after
treatment.
Further
analysis
showed
that
induced
activation
NFE2
Like
BZIP
Transcription
Factor
2
(Nrf2)
tissue
promoted
nuclear
translocation
Nrf2.
Moreover,
hepatoprotective
inhibitory
ferroptosis
attenuated
by
inhibitor
ML385.
alleviates
activating
inhibiting
ferroptosis,
may
be
potential
therapeutic
agent
for
treatment
AILI.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 7, 2025
Sodium
aescinate
(SA),
a
natural
plant
extract
with
various
bioactivities,
is
widely
used
to
treat
oedema
and
inflammation
in
clinics.
However,
adverse
events,
including
liver
injury,
kidney
phlebitis,
have
been
reported
patients
SA
recent
years.
In
this
study,
we
BALB/c
mice
L02
cells
evaluate
the
role
of
ferroptosis
SA-induced
injury.
significantly
increased
AST,
ALT,
MDA
Fe2+,
decreased
GSH
levels,
induced
pathological
changes
vivo.
also
reduced
viability
LDH
release,
intracellular
cysteine
reduction,
depletion,
iron
accumulation,
ROS
production,
lipid
peroxidation,
indicating
that
causes
ferroptosis.
addition,
inhibited
transcriptional
activity
activating
transcription
factor
4
(ATF4)
subsequently
expression
downstream
genes
xCT
(solute
carrier
family
7a
member
11,
SLC7A11)
Cystathionine
gamma-lyase
(CTH)
which
play
vital
roles
biosynthesis.
Interestingly,
cytotoxic
effects
were
effectively
attenuated
by
ATF4
overexpression,
while
they
aggravated
silencing.
These
results
revealed
triggers
hepatocyte
inhibiting
ATF4,
an
oxidative
imbalance.
Antioxidants,
Год журнала:
2023,
Номер
12(7), С. 1383 - 1383
Опубликована: Июль 4, 2023
Interest
in
the
extraction
of
phytochemical
bioactive
compounds,
especially
polyphenols
from
biomass,
has
recently
increased
due
to
their
valuable
biological
potential
as
natural
sources
antioxidants,
which
could
be
used
a
wide
range
applications,
foods
and
pharmaceuticals
green
polymers
bio-based
materials.
The
present
research
study
aimed
provide
comprehensive
chemical
characterization
composition
forest
biomass
(bark
needles)
softwood
species
(Picea
abies
L.,
H.
Karst.,
Abies
alba
Mill.)
investigate
vitro
antioxidant
antimicrobial
activities
assess
treating
healing
infected
chronic
wounds.
DPPH
radical-scavenging
method
P–LD
were
for
mechanistic
explanation
biomolecular
effects
investigated
compounds.
(+)-Catechin,
epicatechin,
rutin,
myricetin,
4
hydroxybenzoic
p-cumaric
acids,
kaempherol,
apigenin
main
quantified
coniferous
(in
quantities
around
100
µg/g).
Also,
numerous
phenolic
flavonoids,
stilbenes,
terpenes,
lignans,
secoiridoids,
indanes
with
antioxidant,
antimicrobial,
anti-inflammatory,
antihemolytic,
anti-carcinogenic
identified.
needle
extract
was
more
toxic
microbial
strains
than
eukaryotic
cells
that
its
active
wound
principles.
In
this
context,
developing
industrial
upscaling
strategies
is
imperative
long-term
success
biorefineries
incorporating
them
part
circular
bio-economy.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
Drug Metabolism and Disposition,
Год журнала:
2024,
Номер
52(8), С. 740 - 753
Опубликована: Июнь 10, 2024
Acetaminophen
(APAP)
is
the
most
commonly
used
over-the-counter
medication
throughout
world.
At
therapeutic
doses,
APAP
has
potent
analgesic
and
antipyretic
effects.
The
efficacy
safety
of
are
influenced
by
multifactorial
processes
dependent
upon
dosing,
namely
frequency
total
dose.
poisoning
repeated
ingestion
supratherapeutic
depletes
glutathione
stores
in
liver
other
organs
capable
metabolic
bioactivation,
leading
to
hepatocellular
death
due
exhausted
antioxidant
defenses.
Numerous
genes,
encompassing
transcription
factors
signaling
pathways,
have
been
identified
as
playing
pivotal
roles
toxicity,
with
being
primary
organ
studied
its
central
role
metabolism
injury.
Nuclear
factor
erythroid
2-related
2
(NRF2)
array
downstream
responsive
genes
crucial
counteracting
toxicity.
NRF2,
along
negative
regulator
Kelch-like
ECH-associated
protein
1,
plays
a
vital
regulating
intracellular
redox
homeostasis.
This
regulation
significant
modulating
oxidative
stress,
inflammation,
induced
APAP.
In
this
review,
we
provide
an
updated
overview
mechanisms
through
which
NRF2
activation
critically
influence
threshold
for
developing
We
also
describe
how
genetically
modified
rodent
models
related
underscoring
significance
response
pathway.
While
focus,
article
comprehensively
explores
genetic
involved
phase
I
II
APAP,
pathways
that
contribute
thereby
providing
holistic
understanding
landscape
influencing
susceptibility
condition.
SIGNIFICANCE
STATEMENT:
review
summarizes
elements
underlying
APAP-induced
focusing
on
protective
NRF2.
delves
into
intricacies
potential
harm.
It
emphasizes
need
deeper
insight
molecular
hepatotoxicity,
especially
interplay
pathways.
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
332, С. 118364 - 118364
Опубликована: Май 18, 2024
Scutellaria
baicalensis
Georgi
(SBG),
a
widely
used
traditional
Chinese
medicine,
exhibits
anti-inflammatory
and
antioxidant
properties.
Wogonin
is
one
of
the
primary
bioactive
components
SBG.
Acetaminophen
(APAP)-induced
liver
injury
(AILI)
represents
prevalent
form
drug-induced
damage
primarily
driven
by
inflammatory
responses
oxidative
stress.
The American Journal of Chinese Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 27
Опубликована: Янв. 17, 2025
This
study
aimed
to
clarify
the
protective
effect
of
Glycyrrhizic
acid
(GL)
against
Diosbulbin
B
(DB)
-
induced
liver
injury
in
mice
and
investigate
its
mechanisms
action.
A
DB
was
established
through
oral
administration
for
15
days.
At
same
time,
GL
administered
treatment.
After
experiment,
pharmacodynamics
ameliorating
DB-induced
were
explored
using
biochemical
indexes,
non-targeted
metabolomics,
targeted
Western
blotting
analysis
protein
expression,
16S
rDNA
sequencing,
Spearman
correlation
analysis.
The
results
show
reduced
function
indices
improved
hepatic
pathological
changes.
It
also
attenuated
inflammation
oxidative
stress.
Hepatic
metabolomics
revealed
that
regulated
ABC
transporters
bile
secretion.
Targeted
(BA)
demonstrated
reduction
BA
efflux
by
regulating
FXR-mediated
transporters.
Furthermore,
gene
sequencing
effectively
restored
relative
abundance
beneficial
bacteria,
harmful
reinstated
structure
intestinal
flora.
Additionally,
analyses
between
flora
indicated
Firmicutes,
Bacteroidota,
TDGA,
DGA,
UDGA,
GDGA,
THDGA,
HDGA
could
serve
as
major
markers
injury.
In
conclusion,
significantly
increasing
expression
Nrf2/FXR-BSEP/MRP2/P-gp/UGT1A1,
promoting
efflux,
flora,
alleviating
