Drug Metabolism and Disposition, Год журнала: 2024, Номер 52(8), С. 704 - 706
Опубликована: Июль 16, 2024
Acetaminophen (APAP), commonly used for its analgesic and antipyretic effects, has been a major focus of research on liver damage due to potential cause severe injury when taken in high doses, leading acute failure and, cases, fatality. The study APAP-induced
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Язык: Английский
Процитировано
3
Xenobiotica, Год журнала: 2025, Номер unknown, С. 1 - 30
Опубликована: Фев. 11, 2025
The Nrf2 signaling pathway is crucial for cellular defense against oxidative stress and xenobiotic toxicity, highlighting its importance in both human health environmental responses.
Язык: Английский
Процитировано
0
Mediterranean Journal of Nutrition and Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Background: Acetaminophen (APAP) overdose, common during pandemics like COVID-19, causes liver injury through oxidative stress. Ginger, known for its antioxidant properties, is suggested as a potential natural remedy. Objective: This study aimed to evaluate the therapeutic and prophylactic efficacy of ethanol ginger extract (GE) suspension (GS) on APAP-induced hepatotoxicity dyslipidemia in rats. Methods: Rats were assigned ten groups: control group, dimethyl sulfoxide groups receiving either GE or GS (150 mg/kg) two weeks. A group given single high dose APAP (2500 mg/kg), pre-treated with before APAP, three repeated doses (500 co-administrated along over Results: administration at regimens significantly impaired function, defenses, lipid metabolism. These disruptions included reduced levels markers such glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), S-transferase (GST), reductase (GR), peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH). Lipid metabolism alterations evident from increased triacylglycerols (TAGs), total cholesterol (T-chol), low-density lipoprotein (LDL-chol), alongside decreased high-density (HDL-chol). The resulted severe damage, indicated by elevated malondialdehyde (MDA), alanine aminotransferase (ALT), alkaline phosphatase (ALP), altered protein fractions. Both treatments alleviated these changes, particularly MDA, ALT, GPx, LDL-chol levels. demonstrated superior protective effects compared GS, restoring GSH, ALP, CAT, SOD, GST, GR, G6PDH, HDL-chol, albumin alpha-1 globulins. In contrast, showed slightly greater reducing TAGs T-chol Conclusions: Ginger extracts offer significant protection against damage dyslipidemia, providing more pronounced effects.
Язык: Английский
Процитировано
0
Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111491 - 111491
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Drug Metabolism and Disposition, Год журнала: 2024, Номер 52(8), С. 704 - 706
Опубликована: Июль 16, 2024
Acetaminophen (APAP), commonly used for its analgesic and antipyretic effects, has been a major focus of research on liver damage due to potential cause severe injury when taken in high doses, leading acute failure and, cases, fatality. The study APAP-induced
Язык: Английский
Процитировано
0