Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117085 - 117085

Опубликована: Сен. 24, 2024

Язык: Английский

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Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies

Critical Reviews in Microbiology, Год журнала: 2024, Номер unknown, С. 1 - 21

Опубликована: Июнь 25, 2024

Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis, most lethal infectious disease resulting in 1.3 million deaths annually. Treatments against Mtb are increasingly impaired by growing prevalence antimicrobial drug resistance, which necessitates development new antibiotics or alternative therapeutic approaches. Upon infecting host cells, predominantly macrophages, becomes critically dependent on lipids as a source nutrients. Additionally, produces numerous lipid-based virulence factors that contribute to pathogen's ability interfere with host's immune responses and create lipid rich environment for itself. As lipids, metabolism manipulating play an important role Mtb, this review provides state-of-the-art overview mycobacterial concomitant host-pathogen interaction therein. While doing so, we will emphasize unexploited bacteria-directed host-directed targets, highlight potential synergistic combinations hold promise interventions.

Язык: Английский

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Neuroprotection of celastrol against postoperative cognitive dysfunction through dampening cGAS-STING signaling

Experimental Neurology, Год журнала: 2024, Номер 382, С. 114987 - 114987

Опубликована: Окт. 5, 2024

Язык: Английский

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Cell-cell crosstalk in the pathogenesis of acute lung injury and acute respiratory distress syndrome

Tissue Barriers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the result of an exaggerated inflammatory response triggered by a variety pulmonary systemic insults. The tissues comprised cell types, including alveolar epithelial cells, vascular endothelial macrophages, neutrophils, others. There is mounting evidence that these diverse populations within interact to regulate inflammation in both direct indirect stimuli. aim this review provide summary discussion recent advances understanding importance cell-cell crosstalk pathogenesis ALI/ARDS, with specific focus on interactions may offer prospective therapeutic avenues for ALI/ARDS.

Язык: Английский

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Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

To investigate the mechanisms behind worsening of acute lung injury (ALI) in obesity, transcriptomic sequencing is performed, and significantly reduced mRNA levels Aconitate Decarboxylase 1 (ACOD1) tissue high-fat diet (HFD) mice are found. Clinical samples collected, an ALI model established HFD mice, both human mouse analyzed, revealing a significant decrease ACOD1 expression alveolar macrophages obesity. Further vivo vitro experiments show that knockdown worsens injury, inflammation, oxidative stress, while overexpression alleviates these effects. Moreover, nuclear factor erythroid 2-related 2 (Nrf2) inhibition diminishes protective effects exacerbated by Additionally, context growth independent (GFI1) protein elevated macrophages, its leads to upregulated expression. Therefore, this study suggests downregulation key likely driven GFI1 upregulation.

Язык: Английский

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STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Апрель 26, 2024

Язык: Английский

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Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension

Respiratory Research, Год журнала: 2024, Номер 25(1)

Опубликована: Март 30, 2024

Abstract Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically M1 macrophages alternatively M2 are both involved in inflammatory related to hypertension. Recent advances suggest that coordinate interactions among proinflammatory anti-inflammatory mediators, other cellular components such as smooth muscle cells fibroblasts. In this review, we summarize the current literature on role pathogenesis hypertension, including origin their response triggers We then discuss cytokines, vascular adventitial fibroblasts well potential therapeutic benefits disease. Identifying critical will contribute a comprehensive understanding pathophysiological abnormality, may provide new perspectives for management.

Язык: Английский

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Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair

Chinese Herbal Medicines, Год журнала: 2024, Номер 16(3), С. 422 - 434

Опубликована: Апрель 30, 2024

Acute lung injury (ALI) is characterized by inflammation and currently lacks an efficacious pharmacological intervention. The medicine combination of

Язык: Английский

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4-Octyl Itaconate Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis Via Regulating Microglia

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Май 18, 2024

Язык: Английский

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Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116899 - 116899

Опубликована: Авг. 23, 2024

Silicosis is a lethal occupational disease caused by long-term exposure to respirable silica dust. Pulmonary macrophages play crucial role in mediating the initiation of silicosis. However, phenotypic and functional heterogeneities pulmonary silicosis have not been well-studied.

Язык: Английский

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