Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 11419 - 11436
Published: Dec. 1, 2024
Acute
lung
injury/acute
respiratory
distress
syndrome
(ALI/ARDS)
is
a
common
and
serious
clinical
disease
characterized
by
extensive
alveolar
damage
inflammation
leading
to
impaired
gas
exchange.Alveolar
macrophages
(AMs)
maintain
homeostatic
properties
immune
defenses
in
tissues.Several
studies
have
reported
that
AMs
are
involved
regulate
ALI/ARDS
onset
progression
via
different
regulated
cell
death
(RCD)
programs,
such
as
pyroptosis,
apoptosis,
autophagic
death,
necroptosis.Notably,
the
effects
of
RCD
complex
variable
depending
on
environment
stimuli.In
this
review,
we
provide
comprehensive
perspective
how
impacts
assess
its
potential
new
therapeutic
development.Additionally,
describe
crosstalk
between
types
ALI,
perspectives
for
treatment
other
severe
diseases.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
202, P. 106710 - 106710
Published: Oct. 28, 2024
Neurodegenerative
diseases
(NDs)
are
a
type
of
common
chronic
progressive
disorders
characterized
by
damage
to
specific
cell
populations
in
the
nervous
system,
ultimately
leading
disability
or
death.
Effective
treatments
for
these
still
lacking,
due
limited
understanding
their
pathogeneses,
which
involve
multiple
cellular
and
molecular
pathways.
The
triggering
an
immune
response
is
feature
neurodegenerative
disorders.
A
critical
challenge
intricate
interplay
between
neuroinflammation,
neurodegeneration,
responses,
not
yet
fully
characterized.
In
recent
years,
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
gene
(STING)
pathway,
crucial
intracellular
DNA
sensing,
has
gradually
gained
attention.
However,
roles
this
pathway
within
types
such
as
cells,
glial
neuronal
its
contribution
ND
pathogenesis,
remain
elucidated.
review,
we
systematically
explore
how
cGAS-STING
signaling
links
various
with
related
effector
pathways
under
context
NDs
multifaceted
therapeutic
directions.
We
emphasize
discovery
condition-dependent
heterogeneity
integral
diverse
responses
potential
targets.
Additionally,
review
pathogenic
role
activation
Parkinson's
disease,
ataxia-telangiectasia,
amyotrophic
lateral
sclerosis.
focus
on
complex
bidirectional
Alzheimer's
Huntington's
sclerosis,
revealing
double-edged
nature
disease
progression.
objective
elucidate
pivotal
pathogenesis
catalyze
new
insights
facilitating
development
novel
strategies.
Respiratory Research,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: March 30, 2024
Abstract
Inflammation
and
immune
processes
underlie
pulmonary
hypertension
progression.
Two
main
different
activated
phenotypes
of
macrophages,
classically
M1
macrophages
alternatively
M2
are
both
involved
in
inflammatory
related
to
hypertension.
Recent
advances
suggest
that
coordinate
interactions
among
proinflammatory
anti-inflammatory
mediators,
other
cellular
components
such
as
smooth
muscle
cells
fibroblasts.
In
this
review,
we
summarize
the
current
literature
on
role
pathogenesis
hypertension,
including
origin
their
response
triggers
We
then
discuss
cytokines,
vascular
adventitial
fibroblasts
well
potential
therapeutic
benefits
disease.
Identifying
critical
will
contribute
a
comprehensive
understanding
pathophysiological
abnormality,
may
provide
new
perspectives
for
management.
Critical Reviews in Microbiology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 21
Published: June 25, 2024
Mycobacterium
tuberculosis
(Mtb)
is
the
causative
pathogen
of
tuberculosis,
most
lethal
infectious
disease
resulting
in
1.3
million
deaths
annually.
Treatments
against
Mtb
are
increasingly
impaired
by
growing
prevalence
antimicrobial
drug
resistance,
which
necessitates
development
new
antibiotics
or
alternative
therapeutic
approaches.
Upon
infecting
host
cells,
predominantly
macrophages,
becomes
critically
dependent
on
lipids
as
a
source
nutrients.
Additionally,
produces
numerous
lipid-based
virulence
factors
that
contribute
to
pathogen's
ability
interfere
with
host's
immune
responses
and
create
lipid
rich
environment
for
itself.
As
lipids,
metabolism
manipulating
play
an
important
role
Mtb,
this
review
provides
state-of-the-art
overview
mycobacterial
concomitant
host-pathogen
interaction
therein.
While
doing
so,
we
will
emphasize
unexploited
bacteria-directed
host-directed
targets,
highlight
potential
synergistic
combinations
hold
promise
interventions.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
284, P. 116899 - 116899
Published: Aug. 23, 2024
Silicosis
is
a
lethal
occupational
disease
caused
by
long-term
exposure
to
respirable
silica
dust.
Pulmonary
macrophages
play
crucial
role
in
mediating
the
initiation
of
silicosis.
However,
phenotypic
and
functional
heterogeneities
pulmonary
silicosis
have
not
been
well-studied.
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 3547 - 3562
Published: Aug. 1, 2023
This
study
aimed
to
investigate
the
role
of
pyroptosis
in
alveolar
macrophages
regarding
immune
microenvironment
acute
respiratory
distress
syndrome
(ARDS)
and
its
prognosis.ARDS
Microarray
data
were
downloaded
from
Gene
Expression
Omnibus
(GEO).
Support
vector
machine
(SVM)
random
forest
(RF)
models
applied
identify
hub
pyroptosis-related
genes
(PRGs)
with
prognostic
significance
ARDS.
RT-PCR
was
used
detect
relative
expression
PRGs
mRNA
ARDS
mice.
Consensus
clustering
analysis
conducted
based
on
modification
patterns.
Bioinformatic
algorithms
traits
biological
functions
Finally,
protein-protein
interaction
(PPI)
networks
established
regulatory
proteins
implications
for
patterns.In
our
study,
a
total
12
differential
obtained.
Four
PRGs,
including
GPX4,
IL6,
IL18
NLRP3,
identified
proven
be
predictive
ventilator-free
days
(VFDS)
patients.
The
AUC
values
4
0.911
(GPX4),
0.879
(IL18),
0.851
(IL6)
0.841
(NLRP3),
respectively.
In
mice,
GPX4
decreased
significantly,
while
IL18,
NLRP3
increased.
Functional
revealed
that
IL6
had
strongest
positive
correlation
CCR
pathway,
exhibited
negative
T
co-inhibition
pathway.
Based
three
patterns
representing
different
states
obtained,
pattern
C
might
represent
storm.The
results
showed
plays
an
important
finding
provides
new
insights
into
pathogenesis,
diagnosis,
treatment
