The American Journal of Chinese Medicine,
Год журнала:
2024,
Номер
52(07), С. 1989 - 2019
Опубликована: Янв. 1, 2024
A
newly
proposed
form
of
programmed
cell
death,
ferroptosis,
is
distinct
in
cellular
morphology,
biochemical
characteristics,
and
genetic
characteristics
from
apoptosis,
autophagy,
necrosis.
Its
mechanisms
primarily
encompass
iron
overload,
lipid
peroxidation,
amino
acid
metabolisms.
Extensive
research
confirms
that
ferroptosis
linked
to
the
onset
progression
various
diseases
pose
a
threat
central
nervous
system
(CNS),
offering
new
directions
targets
for
mechanistic
study
pharmacotherapy
CNS
diseases.
Traditional
Chinese
Medicine
(TCM),
encompassing
herbal
medicines
(extracts,
compound
formulations,
injections,
etc.),
acupuncture,
moxibustion,
boasts
advantages
over
other
treatments,
such
as
multi-pathway
multi-target
approaches
high
safety.
TCM
has
also
demonstrated
good
efficacy
treating
Numerous
studies
indicate
can
modulate
treat
diseases,
showing
promising
prospects.
This
paper
briefly
outlines
pathways
systematically
summarizes
current
status
progress
regulating
through
pathway,
providing
insights
future
treatments
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Journal of Ethnopharmacology,
Год журнала:
2023,
Номер
323, С. 117679 - 117679
Опубликована: Дек. 29, 2023
SuanZaoRen
Decoction
(SZRD),
a
famous
herbal
prescription,
and
has
been
widely
proven
to
have
positive
therapeutic
effects
on
insomnia,
depression
Alzheimer's
disease
(AD).
However,
the
anti-AD
molecular
mechanism
of
SZRD
remains
be
further
investigated.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis
is
a
recently
discovered
type
of
programmed
cell
death
that
mechanistically
different
from
other
types
such
as
apoptosis,
necroptosis,
and
autophagy.
It
characterized
by
the
accumulation
intracellular
iron,
overproduction
reactive
oxygen
species,
depletion
glutathione,
extensive
lipid
peroxidation
lipids
in
membrane.
was
ferroptosis
interconnected
with
many
diseases,
neurodegenerative
ischemia/reperfusion
injury,
cancer,
chronic
kidney
disease.
Polyphenols,
plant
secondary
metabolites
known
for
bioactivities,
are
being
extensively
researched
context
their
influence
on
which
resulted
great
number
publications
showing
need
systematic
review.
In
this
review,
an
literature
search
performed.
Databases
(Scopus,
Web
Science,
PubMed,
ScienceDirect,
Springer)
were
searched
time
span
2017
to
November
2023,
using
keyword
“ferroptosis”
alone
combination
“flavonoid”,
“phenolic
acid”,
“stilbene”,
“coumarin”,
“anthraquinone”,
“chalcone”;
after
selection
studies,
we
had
311
papers
143
phenolic
compounds.
total,
53
compounds
showed
ability
induce
ferroptosis,
110
able
inhibit
out
those
compounds,
20
both
abilities
depending
model
system.
The
most
shikonin,
curcumin,
quercetin,
resveratrol,
baicalin.
common
modes
action
modulation
Nrf2/GPX4
Nrf2/HO-1
axis
iron
metabolism.
Journal of Integrative Neuroscience,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 20, 2025
Alzheimer’s
disease
(AD)
is
a
common
central
neurodegenerative
disorder
characterized
primarily
by
cognitive
impairment
and
non-cognitive
neuropsychiatric
symptoms
that
significantly
impact
patients’
daily
lives
behavioral
functioning.
The
pathogenesis
of
AD
remains
unclear
current
Western
medicines
treatment
are
purely
symptomatic,
with
singular
pathway,
limited
efficacy,
substantial
toxicity
side
effects.
In
recent
years,
as
research
into
has
deepened,
there
been
gradual
increase
in
the
exploration
application
medicinal
plants
for
AD.
Numerous
studies
have
shown
their
active
ingredients
can
potentially
mitigate
regulating
various
molecular
mechanisms,
including
production
aggregation
pathological
proteins,
oxidative
stress,
neuroinflammation,
apoptosis,
mitochondrial
dysfunction,
neurogenesis,
neurotransmission,
brain-gut
microbiota
axis.
this
review,
we
analyzed
comprehensively
summarized
advancements
on
AD,
along
underlying
mechanisms
clinical
evidence.
Ultimately,
aimed
to
provide
reference
further
investigation
specific
through
which
prevent
treat
well
identification
efficacious
derived
from
plants.
BMC Pharmacology and Toxicology,
Год журнала:
2024,
Номер
25(1)
Опубликована: Сен. 6, 2024
The
impact
of
Sodium
Houttuyniae
(SH)
on
lipopolysaccharide
(LPS)-induced
ALI
has
been
investigated
extensively.
However,
it
remains
ambiguous
whether
ferroptosis
participates
in
this
process.
This
study
aimed
to
find
out
the
impacts
and
probable
mechanisms
SH
LPS-induced
ferroptosis.
A
rat
model
type
II
alveolar
epithelial
(ATII)
cell
injury
were
treated
with
LPS.
Enzyme-linked
immunosorbent
assay
(ELISA),
hematoxylin-eosin
(HE)
staining,
Giemsa
staining
executed
ascertain
effects
ALI.
Moreover,
Transmission
electron
microscopy,
Cell
Counting
Kit-8
(CCK8),
ferrous
iron
colorimetric
kit,
Immunohistochemistry,
Immunofluorescence,
Reactive
oxygen
species
western
blotting
(Wb),
qRT-PCR
examined
ferroptosis-related
pathways.
Theresults
found
that
by
using
treatment,
there
was
a
remarkable
attenuation
suppressing
Ferroptosis
demonstrated
decline
levels
glutathione
peroxidase
4
(GPX4),
FTH1,
(GSH)
surge
accumulation
malondialdehyde
(MDA),
reactive
(ROS),
NOX1,
NCOA4,
Fe
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Май 17, 2024
Iron
oxide
nanoparticles
are
a
type
of
nanomaterial
composed
iron
(Fe
3
O
4
or
Fe
2
)
and
have
wide
range
applications
in
magnetic
resonance
imaging.
Compared
to
nanoparticles,
extremely
small
(ESIONPs)
(∼3
nm
diameter)
can
improve
the
imaging
performance
due
smaller
size.
However,
there
currently
no
reports
on
potential
toxic
effects
ESIONPs
human
body.
In
this
study,
we
applied
zebrafish
model
performed
weighted
gene
co-expression
network
analysis
(WGCNA)
differentially
expressed
genes
(DEGs)
embryos
48
hpf,
72
96
120
hpf
using
RNA-seq
technology.
The
key
hub
related
neurotoxicity
ferroptosis
were
identified,
further
experiments
also
demonstrated
that
impaired
neuronal
muscle
development
zebrafish,
induced
ferroptosis,
leading
oxidative
stress,
cell
apoptosis,
inflammatory
response.
Here,
for
first
time,
analyzed
through
WGCNA.
Our
studies
indicate
might
could
induce
while
abnormal
accumulation
ions
increase
risk
early
degenerative
neurological
diseases.
RSC Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Alzheimer's
disease
(AD)
is
a
prevalent
degenerative
disorder
affecting
the
central
nervous
system
of
elderly.
Patients
primarily
manifest
cognitive
decline
and
non-cognitive
neuro-psychiatric
symptoms.
Currently,
western
medications
for
AD
include
cholinesterase
inhibitors
glutamate
receptor
inhibitors,
which
have
limited
efficacy
accompanied
by
significant
toxic
side
effects.
Given
intricate
pathogenesis
AD,
use
single-target
limited.
In
recent
years,
as
research
on
has
progressed,
traditional
Chinese
medicine
(TCM)
its
active
ingredients
increasingly
played
crucial
role
in
clinical
treatment.
Numerous
studies
demonstrate
that
TCM
can
exert
anti-Alzheimer's
effects
modulating
pathological
protein
production
deposition,
inhibiting
tau
hyperphosphorylation,
apoptosis,
inflammation,
oxidative
stress,
while
enhancing
cholinergic
system,
protecting
neurons
synapses,
optimizing
energy
metabolism.
This
article
summarizes
extracts
from
briefly
elucidates
their
pharmacological
mechanisms
against
aiming
to
provide
foundation
further
into
specific
prevention
treatment
disease,
well
identification
efficacious
ingredients.
Journal of Interferon & Cytokine Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Tumor
necrosis
factor
receptor-associated
6
(TRAF6)
has
been
found
to
promote
the
progression
of
acute
pancreatitis
(AP).
However,
its
underlying
molecular
mechanisms
in
AP
need
be
further
revealed.
Caerulein-induced
AR42J
cells
were
used
construct
cell
models.
Cell
viability
and
apoptosis
measured
by
Counting
Kit
8
assay
flow
cytometry.
Levels
inflammatory
factors
oxidative
stress-related
markers
assessed.
The
medium
was
collected
for
coculturing
RAW264.7
cells.
Macrophage
marker
CD86
