Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 18, 2024
Abstract
Acute
lung
injury
(
ALI
)
is
a
common
complication
in
patients
with
severe
burns
and
has
complex
pathogenesis
high
morbidity
mortality
rates.
A
variety
of
drugs
have
been
identified
the
clinic
for
treatment
ALI,
but
they
toxic
side
effects
caused
by
easy
degradation
body
distribution
throughout
body.
In
recent
years,
as
understanding
mechanism
underlying
improved,
scholars
developed
new
nanomaterials
that
can
be
safely
effectively
targeted
ALI.
Most
these
methods
involve
such
lipids,
organic
polymers,
peptides,
extracellular
vesicles
or
cell
membranes,
inorganic
nanoparticles
other
nanomaterials,
which
are
to
reach
tissues
perform
their
functions
through
active
targeting
passive
targeting,
process
involves
cells
organelles.
this
review,
first,
mechanisms
pathophysiological
features
occurrence
after
burn
reviewed,
potential
therapeutic
targets
summarized,
existing
classified,
possible
problems
challenges
discussed
provide
reference
development
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Sepsis-induced
acute
lung
injury
(ALI)
remains
a
leading
cause
of
mortality
in
critically
ill
patients.
Macrophages,
key
modulators
immune
responses,
play
dual
role
both
promoting
and
resolving
inflammation.
Exosomes,
small
extracellular
vesicles
released
by
various
cells,
carry
bioactive
molecules
that
influence
macrophage
polarization
responses.
Emerging
researchers
have
identified
exosomes
as
crucial
mediators
modulate
activity
during
sepsis-induced
ALI.
This
review
explores
the
modulating
functions,
focusing
on
cellular
interactions
within
microenvironment
their
potential
therapeutic
targets.
It
highlights
regulation
macrophages
derived
from
pathogenic
germs,
neutrophils,
alveolar
epithelial
mesenchymal
stromal
cells.
By
understanding
these
mechanisms,
it
aims
to
uncover
innovative
strategies
for
The
inflammatory
response
mediated
by
alveolar
macrophages
plays
a
crucial
role
in
the
development
of
acute
lung
injury.
Numerous
studies
have
reported
that
lncRNAs
are
highly
expressed
injury
mouse
models
and
cell
lines,
(ALI)
can
be
effectively
alleviated
targeting
these
lncRNAs.
aim
this
study
was
to
explore
mechanism
LncRNA
Gm26917
regulates
during
model.
We
initially
observed
significant
upregulation
expression
both
ALI
conditions
MH-S
cells
treated
with
LPS.
Furthermore,
silencing
via
lentivirus-mediated
methods
conferred
protection
against
LPS-induced
ALI.
Additionally,
siRNA-mediated
knockdown
attenuated
responses
modulated
function
macrophages.
Subsequent
mechanistic
revealed
interacts
NKRF,
its
suppressed
NKRF
ubiquitination,
thereby
enhancing
binding
p50
subsequently
inhibiting
NF-κB
signaling
pathway.
In
conclusion,
our
findings
demonstrate
mitigate
modulating
pathway
through
interactions
NKRF.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 847 - 862
Опубликована: Янв. 1, 2025
This
study
evaluated
the
diagnostic
value
of
plasma
Neutrophil
extracellular
traps
(NETs)
levels
and
index
cardiac
electrophysiological
balance
(iCEB)
in
identifying
silent
myocardial
ischemia
(SMI)
maintenance
hemodialysis
(MHD)
patients.
cross-sectional
observational
involved
patients
receiving
MHD
treatment.
Data
were
collected
on
coronary
angiography
performed
our
hospital
from
February
2023
to
2024.
Patients
diagnosed
with
via
but
without
obvious
symptoms
grouped
as
SMI
group,
while
those
control
group.
Plasma
NETs
assessed
using
markers
indicative
components
including
double-stranded
DNA
(dsDNA),
circulating
free
(cfDNA)
myeloperoxidase,
iCEB
(QT/QRS)
electrocardiographic
findings
obtained.
Additionally,
echocardiographic
parameters,
inflammatory
markers,
biomarkers
analyzed.
Receiver
operating
characteristic
(ROC)
analysis
employed
evaluate
accuracy
SMI.
A
total
114
included,
79
participants
group
35
The
exhibited
significantly
elevated
associated
(dsDNA(37.89±4.55
vs
31.64±5.32,
P<0.001),
cfDNA(11.27±2.03
8.91±1.84,
MPO-DNA(23.69±4.01
17.52±3.41,
P<0.001)),
well
higher
compared
group(56.45±7.67
45.89±6.23,
P<0.001).
Furthermore,
electrocardiography
findings,
showed
significant
differences
between
two
groups.
ROC
demonstrated
potential
accuracies
iCEB,
an
area
under
curve
(AUC)
0.908,
sensitivity
0.987,
specificity
0.829
for
highlights
combined
patients,
providing
valuable
insights
into
early
detection
risk
stratification
strategies
this
population.
